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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
16/12/2003 |
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Data da última atualização: |
29/06/2023 |
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Autoria: |
BAILE, C. A.; KEIM, D. A.; DELLA-FERA, M. A.; McLAUGHLIN, C. L. |
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Título: |
Opiate antagonists and agonists and feeding in sheep. |
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Ano de publicação: |
1981 |
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Fonte/Imprenta: |
Physiology and Behavior, v. 26, n. 6, p. 1019-1023, 1981. |
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DOI: |
https://doi.org/10.1016/0031-9384(81)90203-1 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Recent evidence indicates that endogenous opiate peptides may be involved in the control of food intake. In previous experiments, injection of β-endorphin has stimulated food intake and peripheral injections of the opiate antagonist, naloxone, decreased food intake in rats. In the present experiments, food and water intakes of sheep were measured in response to peripherally administered opiate antagonists and continuous lateral ventricular administration of opiate agonists. Intravenous injections of both of the opiate antagonists naloxone (0.03, 0.062 and 0.125 mg/kg) and 3–4(hydroxyl-phenyl)-3-4-dimethyl-piperidine propiophenone maleate (0.03, 0.062 and 0.125 mg/kg) decreased food intake for up to 90 min in 4-hr fasted sheep. In water-deprived sheep, naloxone did not affect water intake or body temperature for the first 4 hr but depressed 24 hr water intake. Continuous 90-min injection of 26, 51 and 102 nmoles/min of the opiate agonist D-ala2-met-enkephalinamide (DME) increased food intake of satiated sheep. Intravenous injection of 0.125 mg/kg naloxone blocked the increase in food intake elicited by intraventricular injection of DME. In contrast, intraventricular injection of kyotorphin, a releasor of endogenous enkephalin in the brain, did not affect food intake. Thus, in sheep intracerebroventricular administration of opiate agonists increased food intake; peripheral administration of opiate antagonists decreased food intake and blocked the feeding induced by agonists. MenosAbstract: Recent evidence indicates that endogenous opiate peptides may be involved in the control of food intake. In previous experiments, injection of β-endorphin has stimulated food intake and peripheral injections of the opiate antagonist, naloxone, decreased food intake in rats. In the present experiments, food and water intakes of sheep were measured in response to peripherally administered opiate antagonists and continuous lateral ventricular administration of opiate agonists. Intravenous injections of both of the opiate antagonists naloxone (0.03, 0.062 and 0.125 mg/kg) and 3–4(hydroxyl-phenyl)-3-4-dimethyl-piperidine propiophenone maleate (0.03, 0.062 and 0.125 mg/kg) decreased food intake for up to 90 min in 4-hr fasted sheep. In water-deprived sheep, naloxone did not affect water intake or body temperature for the first 4 hr but depressed 24 hr water intake. Continuous 90-min injection of 26, 51 and 102 nmoles/min of the opiate agonist D-ala2-met-enkephalinamide (DME) increased food intake of satiated sheep. Intravenous injection of 0.125 mg/kg naloxone blocked the increase in food intake elicited by intraventricular injection of DME. In contrast, intraventricular injection of kyotorphin, a releasor of endogenous enkephalin in the brain, did not affect food intake. Thus, in sheep intracerebroventricular administration of opiate agonists increased food intake; peripheral administration of opiate antagonists decreased food intake and blocked the feeding induced... Mostrar Tudo |
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Palavras-Chave: |
Comportamento alimentar; Endorfina; Opiate peptides; Opioide. |
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Thesagro: |
Consumo Alimentar; Endocrinologia; Nutrição Animal; Ovino; Peptídeo. |
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Thesaurus Nal: |
Enkephalin; Feeding behavior; Naloxone; Ruminant nutrition; Sheep feeding. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02451naa a2200337 a 4500
001 1530075
005 2023-06-29
008 1981 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/0031-9384(81)90203-1$2DOI
100 1 $aBAILE, C. A.
245 $aOpiate antagonists and agonists and feeding in sheep.$h[electronic resource]
260 $c1981
520 $aAbstract: Recent evidence indicates that endogenous opiate peptides may be involved in the control of food intake. In previous experiments, injection of β-endorphin has stimulated food intake and peripheral injections of the opiate antagonist, naloxone, decreased food intake in rats. In the present experiments, food and water intakes of sheep were measured in response to peripherally administered opiate antagonists and continuous lateral ventricular administration of opiate agonists. Intravenous injections of both of the opiate antagonists naloxone (0.03, 0.062 and 0.125 mg/kg) and 3–4(hydroxyl-phenyl)-3-4-dimethyl-piperidine propiophenone maleate (0.03, 0.062 and 0.125 mg/kg) decreased food intake for up to 90 min in 4-hr fasted sheep. In water-deprived sheep, naloxone did not affect water intake or body temperature for the first 4 hr but depressed 24 hr water intake. Continuous 90-min injection of 26, 51 and 102 nmoles/min of the opiate agonist D-ala2-met-enkephalinamide (DME) increased food intake of satiated sheep. Intravenous injection of 0.125 mg/kg naloxone blocked the increase in food intake elicited by intraventricular injection of DME. In contrast, intraventricular injection of kyotorphin, a releasor of endogenous enkephalin in the brain, did not affect food intake. Thus, in sheep intracerebroventricular administration of opiate agonists increased food intake; peripheral administration of opiate antagonists decreased food intake and blocked the feeding induced by agonists.
650 $aEnkephalin
650 $aFeeding behavior
650 $aNaloxone
650 $aRuminant nutrition
650 $aSheep feeding
650 $aConsumo Alimentar
650 $aEndocrinologia
650 $aNutrição Animal
650 $aOvino
650 $aPeptídeo
653 $aComportamento alimentar
653 $aEndorfina
653 $aOpiate peptides
653 $aOpioide
700 1 $aKEIM, D. A.
700 1 $aDELLA-FERA, M. A.
700 1 $aMcLAUGHLIN, C. L.
773 $tPhysiology and Behavior$gv. 26, n. 6, p. 1019-1023, 1981.
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
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