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 | Acesso ao texto completo restrito à biblioteca da Embrapa Caprinos e Ovinos. Para informações adicionais entre em contato com cnpc.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
11/01/2000 |
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Data da última atualização: |
11/12/2023 |
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Autoria: |
MILLER, M. A.; BREMNER, W. J.; CLIFTON, D. K.; DORSA, D. M.; STEINER, R. A. |
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Título: |
Opioid regulation of luteinizing hormone secretion in the male rat. |
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Ano de publicação: |
1986 |
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Fonte/Imprenta: |
Biology of Reproduction, v. 35, n. 1, p. 17-26, Aug. 1986. |
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DOI: |
10.1095/biolreprod35.1.17 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Current evidence suggests that endogenous opioid peptides (EOPs) tonically inhibit secretion of luteinizing hormone (LH) by modulating the release of gonadotropin-releasing hormone (GnRH). Because of their apparent inhibitory actions, EOPs have been assumed to alter both pulse frequency and amplitude of LH in the rat; and it has been hypothesized that EOP pathways mediate the negative feedback actions of steroids on secretion of GnRH. In order to better delineate the role of EOPs in regulating secretion of LH in the male rat, we assessed the effects of a sustained blockade of opiate receptors by naloxone on pulsatile LH release in four groups: intact male rats, acutely castrated male rats implanted for 20 h with a 30-mm capsule made from Silastic and filled with testosterone, acutely castrated male rats implanted for 20 h with an osmotic minipump dispensing 10 mg morphine/24 h, and male rats castrated approximately 20 h before treatment with naloxone. We hypothesized that if EOPs tonically inhibited pulsatile LH secretion, a sustained blockade of opiate receptors should result in a sustained increase in LH release. We found that treatment with naloxone resulted in an immediate but transient increase in LH levels in intact males compared to controls treated with saline. Even though mean levels of LH increased from 0.15 +/- 0.04 to a high of 0.57 +/- 0.14 ng/ml, no significant difference was observed between the groups in either frequency or amplitude of LH pulses across the 4-h treatment period. The transient increase in LH did result in a 3- to 4-fold elevation in levels of plasma testosterone over baseline. This increase in testosterone appeared to correspond with the waning of the LH response to naloxone. The LH response to naloxone was eliminated in acutely castrated rats implanted with testosterone. Likewise, acutely castrated rats treated with morphine also failed to respond to naloxone with an increase in LH. These observations suggest that chronic morphine and chronic testosterone may act through the same mechanism to modulate secretion of LH, or once shut down, the GnRH pulse-generating system becomes refractory to stimulation by naloxone. In acutely castrated male rats, levels of LH were significantly increased above baseline throughout the period of naloxone treatment; this finding supports the hypothesis that the acute elevation in testosterone acting through mechanism independent of opioid is responsible for the transient response of LH to naloxone in the intact rat. MenosAbstract: Current evidence suggests that endogenous opioid peptides (EOPs) tonically inhibit secretion of luteinizing hormone (LH) by modulating the release of gonadotropin-releasing hormone (GnRH). Because of their apparent inhibitory actions, EOPs have been assumed to alter both pulse frequency and amplitude of LH in the rat; and it has been hypothesized that EOP pathways mediate the negative feedback actions of steroids on secretion of GnRH. In order to better delineate the role of EOPs in regulating secretion of LH in the male rat, we assessed the effects of a sustained blockade of opiate receptors by naloxone on pulsatile LH release in four groups: intact male rats, acutely castrated male rats implanted for 20 h with a 30-mm capsule made from Silastic and filled with testosterone, acutely castrated male rats implanted for 20 h with an osmotic minipump dispensing 10 mg morphine/24 h, and male rats castrated approximately 20 h before treatment with naloxone. We hypothesized that if EOPs tonically inhibited pulsatile LH secretion, a sustained blockade of opiate receptors should result in a sustained increase in LH release. We found that treatment with naloxone resulted in an immediate but transient increase in LH levels in intact males compared to controls treated with saline. Even though mean levels of LH increased from 0.15 +/- 0.04 to a high of 0.57 +/- 0.14 ng/ml, no significant difference was observed between the groups in either frequency or amplitude of LH pulses ac... Mostrar Tudo |
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Palavras-Chave: |
LH; Opioide; Orchiectomy; Rato macho; Silicone Elastomers. |
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Thesagro: |
Reprodução. |
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Thesaurus Nal: |
Luteinizing hormone; Morphine; Pharmacology; Radioimmunoassays; Rats; Testosterone. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 03388naa a2200325 a 4500
001 1524076
005 2023-12-11
008 1986 bl uuuu u00u1 u #d
024 7 $a10.1095/biolreprod35.1.17$2DOI
100 1 $aMILLER, M. A.
245 $aOpioid regulation of luteinizing hormone secretion in the male rat.
260 $c1986
520 $aAbstract: Current evidence suggests that endogenous opioid peptides (EOPs) tonically inhibit secretion of luteinizing hormone (LH) by modulating the release of gonadotropin-releasing hormone (GnRH). Because of their apparent inhibitory actions, EOPs have been assumed to alter both pulse frequency and amplitude of LH in the rat; and it has been hypothesized that EOP pathways mediate the negative feedback actions of steroids on secretion of GnRH. In order to better delineate the role of EOPs in regulating secretion of LH in the male rat, we assessed the effects of a sustained blockade of opiate receptors by naloxone on pulsatile LH release in four groups: intact male rats, acutely castrated male rats implanted for 20 h with a 30-mm capsule made from Silastic and filled with testosterone, acutely castrated male rats implanted for 20 h with an osmotic minipump dispensing 10 mg morphine/24 h, and male rats castrated approximately 20 h before treatment with naloxone. We hypothesized that if EOPs tonically inhibited pulsatile LH secretion, a sustained blockade of opiate receptors should result in a sustained increase in LH release. We found that treatment with naloxone resulted in an immediate but transient increase in LH levels in intact males compared to controls treated with saline. Even though mean levels of LH increased from 0.15 +/- 0.04 to a high of 0.57 +/- 0.14 ng/ml, no significant difference was observed between the groups in either frequency or amplitude of LH pulses across the 4-h treatment period. The transient increase in LH did result in a 3- to 4-fold elevation in levels of plasma testosterone over baseline. This increase in testosterone appeared to correspond with the waning of the LH response to naloxone. The LH response to naloxone was eliminated in acutely castrated rats implanted with testosterone. Likewise, acutely castrated rats treated with morphine also failed to respond to naloxone with an increase in LH. These observations suggest that chronic morphine and chronic testosterone may act through the same mechanism to modulate secretion of LH, or once shut down, the GnRH pulse-generating system becomes refractory to stimulation by naloxone. In acutely castrated male rats, levels of LH were significantly increased above baseline throughout the period of naloxone treatment; this finding supports the hypothesis that the acute elevation in testosterone acting through mechanism independent of opioid is responsible for the transient response of LH to naloxone in the intact rat.
650 $aLuteinizing hormone
650 $aMorphine
650 $aPharmacology
650 $aRadioimmunoassays
650 $aRats
650 $aTestosterone
650 $aReprodução
653 $aLH
653 $aOpioide
653 $aOrchiectomy
653 $aRato macho
653 $aSilicone Elastomers
700 1 $aBREMNER, W. J.
700 1 $aCLIFTON, D. K.
700 1 $aDORSA, D. M.
700 1 $aSTEINER, R. A.
773 $tBiology of Reproduction$gv. 35, n. 1, p. 17-26, Aug. 1986.
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Embrapa Caprinos e Ovinos (CNPC) |
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| 13. |  | DAIRIKI, J. K.; BORGHESI, R.; DIAS, C. T. dos S.; CYRINO, J. E. P. Lysine and arginine requirements of Salminus brasiliensis. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 48, n. 8, p. 1012-1020, ago. 2013.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
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| 15. | | HISANO, H.; CARDOSO, I. L.; FERRI, G. H.; PARISE, J.; PINHEIRO, V. R.; BORGHESI, R. Desempenho zootécnico de juvenis de tilápia-do-Nilo alimentados com dietas suplementadas com ácido cítrico. In: CONGRESSO BRASILEIRO DE AQUICULTURA E BIOLOGIA AQUÁTICA, 7., 2016, Belo Horizonte. O uso da água com ciência: resumos... Londrina: Sociedade Brasileira de Aquicultura e Biologia Aquática, 2016. Resumo 691.| Tipo: Resumo em Anais de Congresso |
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| 17. | | INOUE, L. A. K. A.; BORGHESI, R.; SILVA, T. S. de C.; OTA, E. do C. Piscicultura familiar. In: RETORE, M.; PEZARICO, C. R. (ed.). Tecnologias para a agricultura familiar. 4. ed. rev. e atual. Dourados: Embrapa Agropecuária Oeste, 2020. p. 131-134. il. Color. (Embrapa Agropecuária Oeste. Documentos, 122). TECNOFAM| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Agropecuária Oeste; Embrapa Unidades Centrais. |
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| 18. | | INOUE, L. A. K. A.; BORGHESI, R.; SILVA, T. S. de C.; OTA, E. do C. Piscicultura familiar. In: RETORE, M.; PEZARICO, C. R. (ed.). Tecnologias para a agricultura familiar. 5. ed. rev. e atual. Dourados: Embrapa Agropecuária Oeste, 2024. p. 139-142. il. Color. (Embrapa Agropecuária Oeste. Documentos, 122). TECNOFAM 2024; Publicada também como Tecnofam APP.| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Agropecuária Oeste. |
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| 19. | | SILVA, T. S. de C.; BORGHESI, R.; INOUE, L. A. K. A. Piscicultura familiar. In: PADOVAN, M. P.; PEZARICO, C. R.; OTSUBO, A. A. (Ed.). Tecnologias para a agricultura familiar. 2. ed. rev. amp. Dourados: Embrapa Agropecuária Oeste, 2015. p. 100-104 (Embrapa Agropecuária Oeste. Documentos, 122).| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Agropecuária Oeste. |
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| 20. | | SILVA, T. S. de C.; BORGHESI, R.; INOUE, L. A. K. A. Piscicultura familiar. In: PEZARICO, C. R.; RETORE, M. (Ed.). Tecnologias para a agricultura familiar. 3. ed. rev. e atual. Dourados: Embrapa Agropecuária Oeste, 2018. il. color. (Embrapa Agropecuária Oeste. Documentos, 122). p. 139-142| Tipo: Capítulo em Livro Técnico-Científico |
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