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 | Acesso ao texto completo restrito à biblioteca da Embrapa Caprinos e Ovinos. Para informações adicionais entre em contato com cnpc.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
25/03/1996 |
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Data da última atualização: |
01/06/2023 |
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Autoria: |
ITO, K.; TANAKA, T.; MORI, Y. |
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Título: |
Opioid peptidergic control of gonadotropin-releasing hormone pulse generator activity in the ovariectomized goat. |
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Ano de publicação: |
1993 |
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Fonte/Imprenta: |
Neuroendocrinology, v. 57, n. 4, p. 634-639, Apr. 1993. |
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DOI: |
10.1159/000126418 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: The role of endogenous opioid peptides in the control of gonadotropin-releasing hormone pulse generator activity was examined in long-term ovariectomized goats by recording the hypothalamic multiple-unit activity specifically associated with pulsatile luteinizing hormone secretion (MUA volleys). Administration of naloxone, an opioid receptor antagonist, at a rate of 1.0 mg/kg/h for 2 h resulted in shorter (p < 0.05) intervals between MUA volleys than during the control period (61.6 +/- 0.7 vs. 92.5 +/- 7.2 min) in animals treated with progesterone and estradiol that had reproduced a steroidal milieu during the luteal phase. Similarly, in the absence of steroidal treatment, the interval between MUA volleys was shortened (p < 0.01) in a dose-dependent manner from 42.3 +/- 3.7 min (control) to 35.1 +/- 3.9, 32.6 +/- 4.1, and 27.0 +/- 1.7 min when infused with 0.2, 1.0, and 5.0 mg/kg/h of naloxone, respectively. On the other hand, the duration of each MUA volley was lengthened by naloxone. The results indicate that the hypothalamic gonadotropin-releasing hormone pulse generator activity is under a tonic suppression by endogenous opioid peptides in ovariectomized goats. |
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Palavras-Chave: |
Drug effects; GnRH; Peptideos. |
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Thesagro: |
Caprino; Endocrinologia; Estradiol; Reprodução. |
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Thesaurus Nal: |
Electrophysiology; Endorphins; Females; Goats; Gonadotropin-releasing hormone; Hypothalamus; Luteinizing hormone; Pharmacology; Physiology; Progesterone. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02187naa a2200361 a 4500
001 1522880
005 2023-06-01
008 1993 bl uuuu u00u1 u #d
024 7 $a10.1159/000126418$2DOI
100 1 $aITO, K.
245 $aOpioid peptidergic control of gonadotropin-releasing hormone pulse generator activity in the ovariectomized goat.$h[electronic resource]
260 $c1993
520 $aAbstract: The role of endogenous opioid peptides in the control of gonadotropin-releasing hormone pulse generator activity was examined in long-term ovariectomized goats by recording the hypothalamic multiple-unit activity specifically associated with pulsatile luteinizing hormone secretion (MUA volleys). Administration of naloxone, an opioid receptor antagonist, at a rate of 1.0 mg/kg/h for 2 h resulted in shorter (p < 0.05) intervals between MUA volleys than during the control period (61.6 +/- 0.7 vs. 92.5 +/- 7.2 min) in animals treated with progesterone and estradiol that had reproduced a steroidal milieu during the luteal phase. Similarly, in the absence of steroidal treatment, the interval between MUA volleys was shortened (p < 0.01) in a dose-dependent manner from 42.3 +/- 3.7 min (control) to 35.1 +/- 3.9, 32.6 +/- 4.1, and 27.0 +/- 1.7 min when infused with 0.2, 1.0, and 5.0 mg/kg/h of naloxone, respectively. On the other hand, the duration of each MUA volley was lengthened by naloxone. The results indicate that the hypothalamic gonadotropin-releasing hormone pulse generator activity is under a tonic suppression by endogenous opioid peptides in ovariectomized goats.
650 $aElectrophysiology
650 $aEndorphins
650 $aFemales
650 $aGoats
650 $aGonadotropin-releasing hormone
650 $aHypothalamus
650 $aLuteinizing hormone
650 $aPharmacology
650 $aPhysiology
650 $aProgesterone
650 $aCaprino
650 $aEndocrinologia
650 $aEstradiol
650 $aReprodução
653 $aDrug effects
653 $aGnRH
653 $aPeptideos
700 1 $aTANAKA, T.
700 1 $aMORI, Y.
773 $tNeuroendocrinology$gv. 57, n. 4, p. 634-639, Apr. 1993.
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