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 | Acesso ao texto completo restrito à biblioteca da Embrapa Caprinos e Ovinos. Para informações adicionais entre em contato com cnpc.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
01/08/1992 |
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Data da última atualização: |
15/05/2023 |
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Autoria: |
NORWOOD, P. K.; HINKELMANN, K. |
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Título: |
Measures of association between disease and genotype. |
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Ano de publicação: |
1978 |
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Fonte/Imprenta: |
Biometrics, v. 34, n. 4, p. 593-602, 1978. |
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DOI: |
https://doi.org/10.2307/2530378 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: This paper is concerned with the statistical aspects of the phenomenon of disease occurring more frequently in individuals with some genotypes than in individuals with others. A correlation coefficient is defined to quantify association between disease and genotype. A distinction is made between the concepts of independence of allele and disease and independence of genotype and disease. This distinction is used to define two components of association which describe separate aspects of association of disease with genotype. One component is a measure of the association of disease with allele; the other a measure of the effect of allele interaction on association of disease and genotype. One aspect of the usefulness of the partition into components which is discussed is in expressing the recurrence risk of disease for a relative of an affected individual. A chi-squared analysis is provided to test hypotheses about the components of association and other hypotheses of genetic interest. This analysis is illustrated using a study done to determine the effect of the sex-linked dwarfing gene in male chickens on resistance to E. coli infection. This analysis shows a significant allele interaction effect on resistance to disease but no association of disease with alleles. In conclusion, some extensions and limitations of the proposed concepts and procedures are discussed. |
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Palavras-Chave: |
Dwarfism; Escherichia coli Infections; Genetic diseases; Sanidade. |
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Thesagro: |
Resistência Genética. |
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Thesaurus Nal: |
Etiology; Genetic resistance; Genotype. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02072naa a2200241 a 4500
001 1522424
005 2023-05-15
008 1978 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.2307/2530378$2DOI
100 1 $aNORWOOD, P. K.
245 $aMeasures of association between disease and genotype.$h[electronic resource]
260 $c1978
520 $aAbstract: This paper is concerned with the statistical aspects of the phenomenon of disease occurring more frequently in individuals with some genotypes than in individuals with others. A correlation coefficient is defined to quantify association between disease and genotype. A distinction is made between the concepts of independence of allele and disease and independence of genotype and disease. This distinction is used to define two components of association which describe separate aspects of association of disease with genotype. One component is a measure of the association of disease with allele; the other a measure of the effect of allele interaction on association of disease and genotype. One aspect of the usefulness of the partition into components which is discussed is in expressing the recurrence risk of disease for a relative of an affected individual. A chi-squared analysis is provided to test hypotheses about the components of association and other hypotheses of genetic interest. This analysis is illustrated using a study done to determine the effect of the sex-linked dwarfing gene in male chickens on resistance to E. coli infection. This analysis shows a significant allele interaction effect on resistance to disease but no association of disease with alleles. In conclusion, some extensions and limitations of the proposed concepts and procedures are discussed.
650 $aEtiology
650 $aGenetic resistance
650 $aGenotype
650 $aResistência Genética
653 $aDwarfism
653 $aEscherichia coli Infections
653 $aGenetic diseases
653 $aSanidade
700 1 $aHINKELMANN, K.
773 $tBiometrics$gv. 34, n. 4, p. 593-602, 1978.
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| 1. |  | BERTOL, T. M.; FIORENTINI, A. M.; SANTOS, M. J. H. dos; SAWITZKI, A. M.; KAWSKI, V. L.; AGNES, I. B. L.; COATA, C, D.; COLDEBELLA, A.; LOPES, L. dos S. Rosemary extract and celery powder as natural agents to enhance the quality in colonial salami with different maturation times. Ciencia e Tecnologia de Alimentos, v. 32, n. 4, p. 1-10, 2012. Projeto: 01.06.60.106-07.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
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