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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
01/08/1992 |
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Data da última atualização: |
25/07/2023 |
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Autoria: |
LE JAMBRE, L. F.; SOUTHCOTT, W. H.; DASH, K. M. |
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Título: |
Resistance of selected lines of Haemonchus contortus to thiabendazole, morantel tartrate and levamisole. |
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Ano de publicação: |
1976 |
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Fonte/Imprenta: |
International Journal for Parasitology, v. 6, n. 3, p. 217-222, Jul. 1976. |
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DOI: |
10.1016/0020-7519(76)90037-0 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: A field strain of Haemonchus contortus isolated from sheep at Armidale N.S.W., was found to be resistant to thiabendazole with approximately 20 per cent of the worms surviving a 50 mg/kg dose. The isolate was selected over six generations for resistance to 50 mg/kg thiabendazole. After this time, selection on one line was continued at 50 mg/kg thiabendazole and selection on a second line was extended to include 8·8 mg/kg morantel tartrate. A drug tolerance assay on the third generation of the thiabendazole-morantel tartrate selected line showed the ld5o to be 5·3 mg/kg and the ld95 to be 18 mg/kg morantel tartrate; the reported ld50 and ld95 for non-resistant strains of H. contortus to morantel tartrate are 2·5 mg/kg and 8 mg/kg respectively. In the fourth generation the thiabendazole and the thiabendazole-morantel tartrate selected lines together with a recently isolated field strain were assayed for resistance to thiabendazole, morantel tartrate and levamisole. The results indicated that the resistance to thiabendazole was probably due to a single gene. Both selected lines were more resistant to thiabendazole than the field strain. The thiabendazole-morantel tartrate selected line was more resistant to morantel tartrate than either of the other two. Resistance to morantel tartrate appeared to be polygenic in nature and due to increased vigour. The lowest dose of levamisole (1·6 mg/kg) killed more than 95 per cent of all strains of worms. There was no significant increase in effectiveness at higher dose rates indicating that surviving worms were resistant to the drug. MenosAbstract: A field strain of Haemonchus contortus isolated from sheep at Armidale N.S.W., was found to be resistant to thiabendazole with approximately 20 per cent of the worms surviving a 50 mg/kg dose. The isolate was selected over six generations for resistance to 50 mg/kg thiabendazole. After this time, selection on one line was continued at 50 mg/kg thiabendazole and selection on a second line was extended to include 8·8 mg/kg morantel tartrate. A drug tolerance assay on the third generation of the thiabendazole-morantel tartrate selected line showed the ld5o to be 5·3 mg/kg and the ld95 to be 18 mg/kg morantel tartrate; the reported ld50 and ld95 for non-resistant strains of H. contortus to morantel tartrate are 2·5 mg/kg and 8 mg/kg respectively. In the fourth generation the thiabendazole and the thiabendazole-morantel tartrate selected lines together with a recently isolated field strain were assayed for resistance to thiabendazole, morantel tartrate and levamisole. The results indicated that the resistance to thiabendazole was probably due to a single gene. Both selected lines were more resistant to thiabendazole than the field strain. The thiabendazole-morantel tartrate selected line was more resistant to morantel tartrate than either of the other two. Resistance to morantel tartrate appeared to be polygenic in nature and due to increased vigour. The lowest dose of levamisole (1·6 mg/kg) killed more than 95 per cent of all strains of worms. There was no significant ... Mostrar Tudo |
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Palavras-Chave: |
Drug effects; Haemonchiasis; Nematodeos. |
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Thesagro: |
Haemonchus Contortus; Ovino; Parasitologia. |
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Thesaurus Nal: |
Drug resistance; Drug therapy; Gastrointestinal nematodes; Helminths; Levamisole; Morantel; Parasitology; Pharmacology; Pyrimidines; Sheep diseases; Thiabendazole. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02652naa a2200361 a 4500
001 1522056
005 2023-07-25
008 1976 bl uuuu u00u1 u #d
024 7 $a10.1016/0020-7519(76)90037-0$2DOI
100 1 $aLE JAMBRE, L. F.
245 $aResistance of selected lines of Haemonchus contortus to thiabendazole, morantel tartrate and levamisole.$h[electronic resource]
260 $c1976
520 $aAbstract: A field strain of Haemonchus contortus isolated from sheep at Armidale N.S.W., was found to be resistant to thiabendazole with approximately 20 per cent of the worms surviving a 50 mg/kg dose. The isolate was selected over six generations for resistance to 50 mg/kg thiabendazole. After this time, selection on one line was continued at 50 mg/kg thiabendazole and selection on a second line was extended to include 8·8 mg/kg morantel tartrate. A drug tolerance assay on the third generation of the thiabendazole-morantel tartrate selected line showed the ld5o to be 5·3 mg/kg and the ld95 to be 18 mg/kg morantel tartrate; the reported ld50 and ld95 for non-resistant strains of H. contortus to morantel tartrate are 2·5 mg/kg and 8 mg/kg respectively. In the fourth generation the thiabendazole and the thiabendazole-morantel tartrate selected lines together with a recently isolated field strain were assayed for resistance to thiabendazole, morantel tartrate and levamisole. The results indicated that the resistance to thiabendazole was probably due to a single gene. Both selected lines were more resistant to thiabendazole than the field strain. The thiabendazole-morantel tartrate selected line was more resistant to morantel tartrate than either of the other two. Resistance to morantel tartrate appeared to be polygenic in nature and due to increased vigour. The lowest dose of levamisole (1·6 mg/kg) killed more than 95 per cent of all strains of worms. There was no significant increase in effectiveness at higher dose rates indicating that surviving worms were resistant to the drug.
650 $aDrug resistance
650 $aDrug therapy
650 $aGastrointestinal nematodes
650 $aHelminths
650 $aLevamisole
650 $aMorantel
650 $aParasitology
650 $aPharmacology
650 $aPyrimidines
650 $aSheep diseases
650 $aThiabendazole
650 $aHaemonchus Contortus
650 $aOvino
650 $aParasitologia
653 $aDrug effects
653 $aHaemonchiasis
653 $aNematodeos
700 1 $aSOUTHCOTT, W. H.
700 1 $aDASH, K. M.
773 $tInternational Journal for Parasitology$gv. 6, n. 3, p. 217-222, Jul. 1976.
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Embrapa Caprinos e Ovinos (CNPC) |
