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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
01/08/1992 |
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Data da última atualização: |
10/06/2025 |
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Autoria: |
JENSEN, E. V.; DESOMBRE, E. R. |
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Título: |
Estrogen-Receptor Interaction; Estrogenic hormones effect transformation of specific receptor proteins to a biochemically functional form. |
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Ano de publicação: |
1973 |
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Fonte/Imprenta: |
Science, v. 182, n. 4108, p. 126-134, Oct., 1973. |
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DOI: |
10.1126/science.182.4108.126 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: The interaction of estradiol with uterine cells involves the association of the hormone with an extranuclear receptor protein, followed by temperature dependent translocation of the resulting complex to the nucleus. During this process, the steroid binding unit of the protein undergoes an alteration, called "receptor transformation," that can be recognized by an increase in its sedimentation rate from 3.8S to 5.2S, and by its acquisition of the ability to bind to isolated uterine nuclei and to alleviate a tissue specific deficiency in the RNA synthesizing capacity of such nuclei. Receptor transformation can be effected in the absence of nuclei by warming uterine cytosol with estradiol. This preparation of transformed complex resembles that extracted from nuclei both in its sedimentation rate (5.3S) and in its ability to bind to uterine nuclei and augment RNA synthesis, properties that are not shown by the native complex. It is proposed that receptor transformation is an important step in estrogen action and that a principal role of the hormone is to induce conversion of the receptor protein to a biochemically functional form. |
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Thesagro: |
Estrógeno; Fisiologia; Hormônio; Reprodução. |
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Thesaurus Nal: |
Estrogens; Hormones; Reproduction. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 01858naa a2200229 a 4500
001 1521503
005 2025-06-10
008 1973 bl uuuu u00u1 u #d
024 7 $a10.1126/science.182.4108.126$2DOI
100 1 $aJENSEN, E. V.
245 $aEstrogen-Receptor Interaction; Estrogenic hormones effect transformation of specific receptor proteins to a biochemically functional form.$h[electronic resource]
260 $c1973
520 $aAbstract: The interaction of estradiol with uterine cells involves the association of the hormone with an extranuclear receptor protein, followed by temperature dependent translocation of the resulting complex to the nucleus. During this process, the steroid binding unit of the protein undergoes an alteration, called "receptor transformation," that can be recognized by an increase in its sedimentation rate from 3.8S to 5.2S, and by its acquisition of the ability to bind to isolated uterine nuclei and to alleviate a tissue specific deficiency in the RNA synthesizing capacity of such nuclei. Receptor transformation can be effected in the absence of nuclei by warming uterine cytosol with estradiol. This preparation of transformed complex resembles that extracted from nuclei both in its sedimentation rate (5.3S) and in its ability to bind to uterine nuclei and augment RNA synthesis, properties that are not shown by the native complex. It is proposed that receptor transformation is an important step in estrogen action and that a principal role of the hormone is to induce conversion of the receptor protein to a biochemically functional form.
650 $aEstrogens
650 $aHormones
650 $aReproduction
650 $aEstrógeno
650 $aFisiologia
650 $aHormônio
650 $aReprodução
700 1 $aDESOMBRE, E. R.
773 $tScience$gv. 182, n. 4108, p. 126-134, Oct., 1973.
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
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