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 | Acesso ao texto completo restrito à biblioteca da Embrapa Caprinos e Ovinos. Para informações adicionais entre em contato com cnpc.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
01/08/1992 |
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Data da última atualização: |
05/05/2023 |
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Autoria: |
FINDLAY, J. K.; CLARKE, I. J.; ROBERTSON, D. M. |
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Título: |
Inhibin concentrations in ovarian and jugular venous plasma and the relationship of inhibin with follicle-stimulating hormone and luteinizing hormone during the ovine estrous cycle. |
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Ano de publicação: |
1990 |
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Fonte/Imprenta: |
Endocrinology, v. 126, n. 1, p. 528-535, 1990. |
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DOI: |
10.1210/endo-126-1-528 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: A heterologous RIA for ovine inhibin was developed which was sufficiently sensitive and specific to describe the peripheral concentrations of immunoreactive inhibin (iINH) during the estrous cycle of the ewe and to examine the effects of cautery of ovarian follicles on concentrations of iINH in ovarian and jugular venous plasma. Parallel logit-log dose-response lines were observed among ovine follicular fluid, ewe plasma, and pure native ovine (31 kDa) and bovine (31 kDa) inhibin. iINH could not be detected in ovariectomized ewe plasma, and there was no apparent cross-reactivity with a variety of structurally related and unrelated hormones and peptides, except a monomeric form of the alpha-subunit of INH, iINH in follicular fluid was 10(4)-fold higher than that in ovarian venous plasma, which was 3-fold higher than that in peripheral plasma. Cautery of the follicles resulted in a 35% reduction in iINH and an 81% reduction in estrogen concentrations in the ovarian vein within 10 min. During the estrous cycle, iINH and FSH were inversely related in samples taken over 30 h in the luteal phase (r = -0.69; P less than 0.001) and in the pre- and postovulatory phases (r = -0.45; P less than 0.001). iINH and LH were not related in the luteal phase, but were weakly positively correlated in the follicular phase (r = 0.31; P less than 0.01). iINH and estrogen concentrations in the follicular phase were also weakly correlated (r = 0.30; P less than 0.001). Furthermore, iINH concentrations rose in the follicular phase and decreased within 3-6 h of the preovulatory surges of LH and FSH, reaching a nadir around the time of the second rise in FSH 24-48 h later. It is concluded that 1) large antral follicles are a major source of peripheral iINH during the ovine estrous cycle; 2) iINH levels increase in the follicular phase with the growth of the dominant follicle and may be inhibited by the preovulatory surge of gonadotropin; 3) the fall in inhibin after the LH surge may be responsible for the second rise in FSH; and 4) the inverse relationship between FSH and iINH is consistent with the hypothesis that inhibin is involved in the feedback regulation of FSH. MenosAbstract: A heterologous RIA for ovine inhibin was developed which was sufficiently sensitive and specific to describe the peripheral concentrations of immunoreactive inhibin (iINH) during the estrous cycle of the ewe and to examine the effects of cautery of ovarian follicles on concentrations of iINH in ovarian and jugular venous plasma. Parallel logit-log dose-response lines were observed among ovine follicular fluid, ewe plasma, and pure native ovine (31 kDa) and bovine (31 kDa) inhibin. iINH could not be detected in ovariectomized ewe plasma, and there was no apparent cross-reactivity with a variety of structurally related and unrelated hormones and peptides, except a monomeric form of the alpha-subunit of INH, iINH in follicular fluid was 10(4)-fold higher than that in ovarian venous plasma, which was 3-fold higher than that in peripheral plasma. Cautery of the follicles resulted in a 35% reduction in iINH and an 81% reduction in estrogen concentrations in the ovarian vein within 10 min. During the estrous cycle, iINH and FSH were inversely related in samples taken over 30 h in the luteal phase (r = -0.69; P less than 0.001) and in the pre- and postovulatory phases (r = -0.45; P less than 0.001). iINH and LH were not related in the luteal phase, but were weakly positively correlated in the follicular phase (r = 0.31; P less than 0.01). iINH and estrogen concentrations in the follicular phase were also weakly correlated (r = 0.30; P less than 0.001). Furthermore, iINH co... Mostrar Tudo |
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Palavras-Chave: |
Blood supply; Follicle Stimulating Hormone; Jugular Veins; LH; Osmolar concentration; Ovary metabolism. |
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Thesagro: |
Ciclo Estral; Endocrinologia; Ovino; Reprodução. |
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Thesaurus Nal: |
Body fluids; Circadian rhythm; Estrus; Inhibin; Luteinizing hormone; Radioimmunoassays; Sheep. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 03276naa a2200361 a 4500
001 1520696
005 2023-05-05
008 1990 bl uuuu u00u1 u #d
024 7 $a10.1210/endo-126-1-528$2DOI
100 1 $aFINDLAY, J. K.
245 $aInhibin concentrations in ovarian and jugular venous plasma and the relationship of inhibin with follicle-stimulating hormone and luteinizing hormone during the ovine estrous cycle.$h[electronic resource]
260 $c1990
520 $aAbstract: A heterologous RIA for ovine inhibin was developed which was sufficiently sensitive and specific to describe the peripheral concentrations of immunoreactive inhibin (iINH) during the estrous cycle of the ewe and to examine the effects of cautery of ovarian follicles on concentrations of iINH in ovarian and jugular venous plasma. Parallel logit-log dose-response lines were observed among ovine follicular fluid, ewe plasma, and pure native ovine (31 kDa) and bovine (31 kDa) inhibin. iINH could not be detected in ovariectomized ewe plasma, and there was no apparent cross-reactivity with a variety of structurally related and unrelated hormones and peptides, except a monomeric form of the alpha-subunit of INH, iINH in follicular fluid was 10(4)-fold higher than that in ovarian venous plasma, which was 3-fold higher than that in peripheral plasma. Cautery of the follicles resulted in a 35% reduction in iINH and an 81% reduction in estrogen concentrations in the ovarian vein within 10 min. During the estrous cycle, iINH and FSH were inversely related in samples taken over 30 h in the luteal phase (r = -0.69; P less than 0.001) and in the pre- and postovulatory phases (r = -0.45; P less than 0.001). iINH and LH were not related in the luteal phase, but were weakly positively correlated in the follicular phase (r = 0.31; P less than 0.01). iINH and estrogen concentrations in the follicular phase were also weakly correlated (r = 0.30; P less than 0.001). Furthermore, iINH concentrations rose in the follicular phase and decreased within 3-6 h of the preovulatory surges of LH and FSH, reaching a nadir around the time of the second rise in FSH 24-48 h later. It is concluded that 1) large antral follicles are a major source of peripheral iINH during the ovine estrous cycle; 2) iINH levels increase in the follicular phase with the growth of the dominant follicle and may be inhibited by the preovulatory surge of gonadotropin; 3) the fall in inhibin after the LH surge may be responsible for the second rise in FSH; and 4) the inverse relationship between FSH and iINH is consistent with the hypothesis that inhibin is involved in the feedback regulation of FSH.
650 $aBody fluids
650 $aCircadian rhythm
650 $aEstrus
650 $aInhibin
650 $aLuteinizing hormone
650 $aRadioimmunoassays
650 $aSheep
650 $aCiclo Estral
650 $aEndocrinologia
650 $aOvino
650 $aReprodução
653 $aBlood supply
653 $aFollicle Stimulating Hormone
653 $aJugular Veins
653 $aLH
653 $aOsmolar concentration
653 $aOvary metabolism
700 1 $aCLARKE, I. J.
700 1 $aROBERTSON, D. M.
773 $tEndocrinology$gv. 126, n. 1, p. 528-535, 1990.
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Embrapa Caprinos e Ovinos (CNPC) |
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| 1. |  | MARQUES, R. F.; CORREIA, I. V. T.; MELO, T. S.; SILVA, L. B. X. da; LINHARES, L. T.; CARRARO, T. V.; CONCENCO, G. Alelopatia de extratos de sorgo-sacarino sobre capim-amargoso. In: JORNADA DE INICIAÇÃO À PESQUISA DA EMBRAPA, 2015, Dourados. Resumos... Brasília, DF: Embrapa, 2015. JIPE 2015.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agropecuária Oeste. |
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| 2. | | LINHARES, L. T.; MELO, T. S.; SILVA, L. B. X. da; CARRARO, T. V.; CORREIA, I. V. T.; MARQUES, R. F.; CONCENCO, G. Efeito alelopático de sorgo-sacarino sobre o capim-amargoso. In: JORNADA DE INICIAÇÃO À PESQUISA DA EMBRAPA, 2015, Dourados. Resumos... Brasília, DF: Embrapa, 2015. JIPE 2015.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agropecuária Oeste. |
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| Registros recuperados : 2 | |
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