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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
01/08/1992 |
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Data da última atualização: |
08/11/2023 |
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Autoria: |
ROBINSON, T. J.; BRANDER, W. M. |
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Título: |
Comparative activies of a number of oestrogens when administered intravenously and intramusculary in the sheep. |
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Ano de publicação: |
1962 |
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Fonte/Imprenta: |
Journal of Reproduction and Fertility, v. 3, n. 1, p. 74-88, Feb. 1962. |
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DOI: |
10.1530/jrf.0.0030074 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: The activities of six oestrogenic substances were compared when given as a single injection, intravenously (i/v) or intramuscularly (i/m), to spayed progesterone-primed ewes. The following values for the ED50 for oestrous behaviour, with associated 95% fiducial limits, were obtained: Oestradiol-17? (i/v) 16 ?, 25 ? 39; (i/m) 3 ? 7 ? 16; Oestradiol benzoate (i/v) 30 ? 45 ? 69; (i/m) 5 ? 11 ? 23; Oestrone (i/v) 48 ? 96 ? 194; (i/m) No data; Diethylstilboestrol (i/v) 6 ? 10 ? 18; (i/m) 6 ? 10 ? 18; Hexoestrol (i/v) 46 ? 103 ? 234; (i/m) 46 ? 103 ? 234; Methylethylstilboestrol (i/v) ? ? ; (i/m) 130 ? 279 ? 600; They fell into three groups, with the following i/v : i/m ratios: natural oestrogens; oestradiol- 17?, oestradiol benzoate, 4 : 1: synthetic oestrogens; diethylstilboestrol and hexoestrol, 1 : 1 : pro-oestrogen; methylethylstilboestrol, ? : 1. True oestrogens are presumed to accumulate in the reacting tissues with variable efficiencies. Pro-oestrogens, given i/v, are probably ineffective because they are not converted to oestrogens in a manner or at a rate suitable for such accumulation. |
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Palavras-Chave: |
Estradiol Congeners. |
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Thesagro: |
Endocrinologia; Estrógeno; Fisiologia; Hormônio; Ovino; Reprodução. |
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Thesaurus Nal: |
Animal reproduction; Estrogens; Estrus; Intramuscular injection; Pharmacology; Sheep. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 01996naa a2200301 a 4500
001 1520394
005 2023-11-08
008 1962 bl uuuu u00u1 u #d
024 7 $a10.1530/jrf.0.0030074$2DOI
100 1 $aROBINSON, T. J.
245 $aComparative activies of a number of oestrogens when administered intravenously and intramusculary in the sheep.$h[electronic resource]
260 $c1962
520 $aAbstract: The activities of six oestrogenic substances were compared when given as a single injection, intravenously (i/v) or intramuscularly (i/m), to spayed progesterone-primed ewes. The following values for the ED50 for oestrous behaviour, with associated 95% fiducial limits, were obtained: Oestradiol-17? (i/v) 16 ?, 25 ? 39; (i/m) 3 ? 7 ? 16; Oestradiol benzoate (i/v) 30 ? 45 ? 69; (i/m) 5 ? 11 ? 23; Oestrone (i/v) 48 ? 96 ? 194; (i/m) No data; Diethylstilboestrol (i/v) 6 ? 10 ? 18; (i/m) 6 ? 10 ? 18; Hexoestrol (i/v) 46 ? 103 ? 234; (i/m) 46 ? 103 ? 234; Methylethylstilboestrol (i/v) ? ? ; (i/m) 130 ? 279 ? 600; They fell into three groups, with the following i/v : i/m ratios: natural oestrogens; oestradiol- 17?, oestradiol benzoate, 4 : 1: synthetic oestrogens; diethylstilboestrol and hexoestrol, 1 : 1 : pro-oestrogen; methylethylstilboestrol, ? : 1. True oestrogens are presumed to accumulate in the reacting tissues with variable efficiencies. Pro-oestrogens, given i/v, are probably ineffective because they are not converted to oestrogens in a manner or at a rate suitable for such accumulation.
650 $aAnimal reproduction
650 $aEstrogens
650 $aEstrus
650 $aIntramuscular injection
650 $aPharmacology
650 $aSheep
650 $aEndocrinologia
650 $aEstrógeno
650 $aFisiologia
650 $aHormônio
650 $aOvino
650 $aReprodução
653 $aEstradiol Congeners
700 1 $aBRANDER, W. M.
773 $tJournal of Reproduction and Fertility$gv. 3, n. 1, p. 74-88, Feb. 1962.
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
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