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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
26/02/1996 |
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Data da última atualização: |
01/02/2024 |
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Autoria: |
STANKIEWICZ, M.; CABAJ, W.; JONAS, W. E.; MOORE, L. G.; MILLAR, K.; NG CHIE, W. |
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Título: |
Influence of ivermectin on cellular and humoral immune responses of lambs. |
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Ano de publicação: |
1995 |
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Fonte/Imprenta: |
Veterinary Immunology and Immunopathology, v. 44, n. 3/4, p. 347-358, Feb. 1995. |
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DOI: |
https://doi.org/10.1016/0165-2427(94)05308-F |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: In view of the extensive use of anthelmintics in sheep and the fact that their activity may in part depend upon the immune system, we were interested to determine if ivermectin had any influence on aspects of the sheep immune response. Ten parasite-free 6-month-old lambs were drenched with ivermectin and 1 day later were given intravenously human erythrocytes and subcutaneously ovalbumin. Ten other lambs with injected antigens were not drenched and served as controls. Both groups were bled at intervals for cells and serum. The procedure was repeated on day 28. Lymphocytes from the drenched lambs, cultured in vitro in RPMI plus 50% autologous serum collected up to 7 and 14 days after the first and second antigen injections respectively, had decreased blastogenic activity compared with lymphocytes from control lambs. Similar results were obtained with lymphocytes cultured in RPMI 1640 supplemented with 50% autologous serum plus concanavalin A (Con A) or phytohaemagglutinin (PHA). When washed, lymphocytes were cultured in RPMI 1640 supplemented with 5% foetal calf serum (FCS) or 5% FCS plus Con A or PHA, decreased blastogenesis was observed but blastogenesis depression was not as marked as that observed with autologous serum. Similar antibody responses were seen for the drenched and control groups in response to the two injections of both antigens except that after the second injection, there was a significant reduction in antibody response to ovalbumin in the ivermectin-treated lambs. There were no differences in serum complement or serum nitric oxide levels between the two groups at any stage, but insulin-like growth factor-1 levels were significantly reduced in serum of the ivermectin-treated group, 4 days after each drench. Growth hormone levels were consistently significantly higher 22 days after both drenchings. There was no difference in mean body weight increase between the groups during the experiment. MenosAbstract: In view of the extensive use of anthelmintics in sheep and the fact that their activity may in part depend upon the immune system, we were interested to determine if ivermectin had any influence on aspects of the sheep immune response. Ten parasite-free 6-month-old lambs were drenched with ivermectin and 1 day later were given intravenously human erythrocytes and subcutaneously ovalbumin. Ten other lambs with injected antigens were not drenched and served as controls. Both groups were bled at intervals for cells and serum. The procedure was repeated on day 28. Lymphocytes from the drenched lambs, cultured in vitro in RPMI plus 50% autologous serum collected up to 7 and 14 days after the first and second antigen injections respectively, had decreased blastogenic activity compared with lymphocytes from control lambs. Similar results were obtained with lymphocytes cultured in RPMI 1640 supplemented with 50% autologous serum plus concanavalin A (Con A) or phytohaemagglutinin (PHA). When washed, lymphocytes were cultured in RPMI 1640 supplemented with 5% foetal calf serum (FCS) or 5% FCS plus Con A or PHA, decreased blastogenesis was observed but blastogenesis depression was not as marked as that observed with autologous serum. Similar antibody responses were seen for the drenched and control groups in response to the two injections of both antigens except that after the second injection, there was a significant reduction in antibody response to ovalbumin in the ivermec... Mostrar Tudo |
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Palavras-Chave: |
Drug effects; Growth Hormone; Imunidade Iverhectin. |
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Thesagro: |
Ovino; Parasitologia. |
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Thesaurus Nal: |
Immunology; Insulin-like growth factor I; Ivermectin; Nitric oxide; Pharmacology; Sheep. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 02887naa a2200325 a 4500
001 1516952
005 2024-02-01
008 1995 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/0165-2427(94)05308-F$2DOI
100 1 $aSTANKIEWICZ, M.
245 $aInfluence of ivermectin on cellular and humoral immune responses of lambs.$h[electronic resource]
260 $c1995
520 $aAbstract: In view of the extensive use of anthelmintics in sheep and the fact that their activity may in part depend upon the immune system, we were interested to determine if ivermectin had any influence on aspects of the sheep immune response. Ten parasite-free 6-month-old lambs were drenched with ivermectin and 1 day later were given intravenously human erythrocytes and subcutaneously ovalbumin. Ten other lambs with injected antigens were not drenched and served as controls. Both groups were bled at intervals for cells and serum. The procedure was repeated on day 28. Lymphocytes from the drenched lambs, cultured in vitro in RPMI plus 50% autologous serum collected up to 7 and 14 days after the first and second antigen injections respectively, had decreased blastogenic activity compared with lymphocytes from control lambs. Similar results were obtained with lymphocytes cultured in RPMI 1640 supplemented with 50% autologous serum plus concanavalin A (Con A) or phytohaemagglutinin (PHA). When washed, lymphocytes were cultured in RPMI 1640 supplemented with 5% foetal calf serum (FCS) or 5% FCS plus Con A or PHA, decreased blastogenesis was observed but blastogenesis depression was not as marked as that observed with autologous serum. Similar antibody responses were seen for the drenched and control groups in response to the two injections of both antigens except that after the second injection, there was a significant reduction in antibody response to ovalbumin in the ivermectin-treated lambs. There were no differences in serum complement or serum nitric oxide levels between the two groups at any stage, but insulin-like growth factor-1 levels were significantly reduced in serum of the ivermectin-treated group, 4 days after each drench. Growth hormone levels were consistently significantly higher 22 days after both drenchings. There was no difference in mean body weight increase between the groups during the experiment.
650 $aImmunology
650 $aInsulin-like growth factor I
650 $aIvermectin
650 $aNitric oxide
650 $aPharmacology
650 $aSheep
650 $aOvino
650 $aParasitologia
653 $aDrug effects
653 $aGrowth Hormone
653 $aImunidade Iverhectin
700 1 $aCABAJ, W.
700 1 $aJONAS, W. E.
700 1 $aMOORE, L. G.
700 1 $aMILLAR, K.
700 1 $aNG CHIE, W.
773 $tVeterinary Immunology and Immunopathology$gv. 44, n. 3/4, p. 347-358, Feb. 1995.
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| 8. |  | RIBEIRO, J. P. N.; TAKAO, L. K.; MATSUMOTO, R. S.; URBANETZ, C.; LIMA, M. I. S. Plantae, aquatic, amphibian and marginal species, Massaguaçu River Estuary, Caraguatatuba, São Paulo, Brazil. Check List, v. 7, n. 2, 2011.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 4 |
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| 11. | | RIBEIRO, J. P. O.; CAMPOS, W. de O.; ESPÍRITO SANTO, A. do; RIBEIRO, A. C. O.; PARRELLA, N. N. L. D.; PARRELLA, R. A. da C.; SILVA, A. F. da. Teor de água em sementes de três genótipos de sorgo sacarino ao longo de oito épocas de colheita. In: CONGRESSO NACIONAL DE MILHO E SORGO, 32., 2018, Lavras. Soluções integradas para os sistemas de produção de milho e sorgo no Brasil: resumos. Sete Lagoas: Associação Brasileira de Milho e Sorgo, 2018. p. 225.| Tipo: Resumo em Anais de Congresso |
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| 12. | | RIBEIRO, J. P. O.; BERTOLI, C. A.; ESPÍRITO SANTO, A. do; CAMPOS, W. de O.; BRAGA NETO, J. F.; PARRELLA, N. N. L. D.; PARRELLA, R. A. da C. Maturação do colmo de dez genótipos de sorgo sacarino. In: CONGRESSO NACIONAL DE MILHO E SORGO, 32., 2018, Lavras. Soluções integradas para os sistemas de produção de milho e sorgo no Brasil: resumos. Sete Lagoas: Associação Brasileira de Milho e Sorgo, 2018. p. 199.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 13. | | ALENCAR, A.; SHIMBO, J. Z.; LENTI, F.; MARQUES, C. B.; ZIMBRES, B.; ROSA, M.; ARRUDA, V.; CASTRO, I.; RIBEIRO, J. P. F. M.; VARELA, V.; ALENCAR, I.; PIONTEKOWSKI, V.; RIBEIRO, V.; BUSTAMANTE, M. M. C.; SANO, E. E.; BARROSO, M. Mapping Three Decades of Changes in the Brazilian Savanna Native Vegetation Using Landsat Data Processed in the Google Earth Engine Platform. Remote Sensing, v. 12, n. 6, 2020.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
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| 14. | | MATRANGOLO, W. J. R.; BRASILEIRO, B. P.; SILVA, C. J. da; NETTO, D. A. M.; MATTAR, E. P. L.; FRADE JÚNIOR, E. F.; SILVA, I. H. F. da; SILVA, I. S. da; CRIVELARO, J. C. B.; RIBEIRO, J. P. O.; FERRAZ, L. de C. L.; COSTA, L. S. C.; MALTA, P. da C. C.; CRUZ, S. C. B. da; GOMES, S. X.; GONÇALVES, V. A. D. Aspectos de Cratylia argentea na região central de Minas Gerais e potencialidades em sistemas agrobiodiversos. Sete Lagoas: Embrapa Milho e Sorgo, 2018. 41 p. (Embrapa Milho e Sorgo. Comunicado Técnico, 233).| Tipo: Comunicado Técnico/Recomendações Técnicas |
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| Registros recuperados : 14 | |
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