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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
10/04/1996 |
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Data da última atualização: |
26/09/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
VIEIRA, L. da S.; BERNE, M. E. A.; CAVALCANTE, A. C. R.; COSTA, C. A. F. |
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Afiliação: |
Luiz da Silva Vieira, CNPC; Maria Elisabeth Aires Berne, CNPC; Antônio César Rocha Cavalcante, CNPC; Carlos Alberto Fagonde Costa, CNPC. |
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Título: |
Haemonchus contortus resistance to ivermectin and netobimin in Brazilian sheep. |
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Ano de publicação: |
1992 |
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Fonte/Imprenta: |
Veterinary Parasitology, v. 45, n. 1/2, p. 111-116, 1992. |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract - Suffolk, Texel, Hampshire Down and Ile de France sheep from the municipalities of Porto Amazonas, Piraquara and Araucaria in the State of Paraná, and Bagé in the State of Rio Grande do Sul were brought to Sobral, State of Ceará, to be used in a cross-breeding project. On arrival they had clinical signs of nematode parasitosis, and one Suffolk female died. The animals were treated orally with ivermectin (0.2 mg kg−1) and fifteen days later with netobimin (20.0 mg kg−1). Neither drug reduced the egg counts (measured in eggs per gram, EPG) significantly, and this suggested that the nematodes in the sheep were resistant to the anthelmintics used. Haemonchus contortus was the species involved. The egg counts were reduced after oral treatment with trichlorfon (100.0 mg kg−1). Haemonchus contortus larvae obtained from these animals before trichlorfon treatment and passaged through two nematode-free sheep were used in a further experiment.Twenty 6- to 9-month-old nematode-free lambs were infected with the H. contortus larvae (10 000 per animal) and, after the infection was confirmed, were randomly divided into four groups of five animals. Group I was orally treated with ivermectin at 0.2 mg kg−1, Group II with oral netobimin at 20.0 mg kg−1, Group III with oral trichlorfon at 100.0 mg kg−1 and Group IV was a non-treated control. Egg counts and faecal cultures were taken before dosing on the day of treatment and seven days later when all animals were necropsied and the nematodes were collected from the abomasa and counted. Drug efficacy measured by the reduction in adult H. contortus numbers was 99.9% for trichlorfon, 38.9% for netobimin and 17.6% for ivermectin. The results demonstrated the resistance of this strain of H. Contortus to ivermectin and netobimin. MenosAbstract - Suffolk, Texel, Hampshire Down and Ile de France sheep from the municipalities of Porto Amazonas, Piraquara and Araucaria in the State of Paraná, and Bagé in the State of Rio Grande do Sul were brought to Sobral, State of Ceará, to be used in a cross-breeding project. On arrival they had clinical signs of nematode parasitosis, and one Suffolk female died. The animals were treated orally with ivermectin (0.2 mg kg−1) and fifteen days later with netobimin (20.0 mg kg−1). Neither drug reduced the egg counts (measured in eggs per gram, EPG) significantly, and this suggested that the nematodes in the sheep were resistant to the anthelmintics used. Haemonchus contortus was the species involved. The egg counts were reduced after oral treatment with trichlorfon (100.0 mg kg−1). Haemonchus contortus larvae obtained from these animals before trichlorfon treatment and passaged through two nematode-free sheep were used in a further experiment.Twenty 6- to 9-month-old nematode-free lambs were infected with the H. contortus larvae (10 000 per animal) and, after the infection was confirmed, were randomly divided into four groups of five animals. Group I was orally treated with ivermectin at 0.2 mg kg−1, Group II with oral netobimin at 20.0 mg kg−1, Group III with oral trichlorfon at 100.0 mg kg−1 and Group IV was a non-treated control. Egg counts and faecal cultures were taken before dosing on the day of treatment and seven days later when all... Mostrar Tudo |
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Palavras-Chave: |
Contagem de ovos; Faeces; Gastrintestinal nematode; Nematódeo gastrintestinal; Netobimin; Parasite Egg Count; Resistance to chemicals; Resistência a drogas; Therapeutic use. |
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Thesagro: |
Anti-helmíntico; Dose; Fezes; Haemonchus contortus; Helminto gastrintestinal; Nematóide; Ovino; Parasitologia; Resistência química. |
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Thesaurus Nal: |
Anthelmintics; Dosage; Drug resistance; Guanidines; Ivermectin; Nematode infections; Parasitology; Sheep; trichlorfon. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 03155naa a2200481 a 4500
001 1514695
005 2019-09-26
008 1992 bl uuuu u00u1 u #d
100 1 $aVIEIRA, L. da S.
245 $aHaemonchus contortus resistance to ivermectin and netobimin in Brazilian sheep.$h[electronic resource]
260 $c1992
520 $aAbstract - Suffolk, Texel, Hampshire Down and Ile de France sheep from the municipalities of Porto Amazonas, Piraquara and Araucaria in the State of Paraná, and Bagé in the State of Rio Grande do Sul were brought to Sobral, State of Ceará, to be used in a cross-breeding project. On arrival they had clinical signs of nematode parasitosis, and one Suffolk female died. The animals were treated orally with ivermectin (0.2 mg kg−1) and fifteen days later with netobimin (20.0 mg kg−1). Neither drug reduced the egg counts (measured in eggs per gram, EPG) significantly, and this suggested that the nematodes in the sheep were resistant to the anthelmintics used. Haemonchus contortus was the species involved. The egg counts were reduced after oral treatment with trichlorfon (100.0 mg kg−1). Haemonchus contortus larvae obtained from these animals before trichlorfon treatment and passaged through two nematode-free sheep were used in a further experiment.Twenty 6- to 9-month-old nematode-free lambs were infected with the H. contortus larvae (10 000 per animal) and, after the infection was confirmed, were randomly divided into four groups of five animals. Group I was orally treated with ivermectin at 0.2 mg kg−1, Group II with oral netobimin at 20.0 mg kg−1, Group III with oral trichlorfon at 100.0 mg kg−1 and Group IV was a non-treated control. Egg counts and faecal cultures were taken before dosing on the day of treatment and seven days later when all animals were necropsied and the nematodes were collected from the abomasa and counted. Drug efficacy measured by the reduction in adult H. contortus numbers was 99.9% for trichlorfon, 38.9% for netobimin and 17.6% for ivermectin. The results demonstrated the resistance of this strain of H. Contortus to ivermectin and netobimin.
650 $aAnthelmintics
650 $aDosage
650 $aDrug resistance
650 $aGuanidines
650 $aIvermectin
650 $aNematode infections
650 $aParasitology
650 $aSheep
650 $atrichlorfon
650 $aAnti-helmíntico
650 $aDose
650 $aFezes
650 $aHaemonchus contortus
650 $aHelminto gastrintestinal
650 $aNematóide
650 $aOvino
650 $aParasitologia
650 $aResistência química
653 $aContagem de ovos
653 $aFaeces
653 $aGastrintestinal nematode
653 $aNematódeo gastrintestinal
653 $aNetobimin
653 $aParasite Egg Count
653 $aResistance to chemicals
653 $aResistência a drogas
653 $aTherapeutic use
700 1 $aBERNE, M. E. A.
700 1 $aCAVALCANTE, A. C. R.
700 1 $aCOSTA, C. A. F.
773 $tVeterinary Parasitology$gv. 45, n. 1/2, p. 111-116, 1992.
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
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