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Biblioteca(s): |
Embrapa Meio Ambiente. |
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Data corrente: |
15/01/2008 |
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Data da última atualização: |
25/03/2014 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
CASTRO, V. L. S. S. de; DESTEFANI, C. R.; DINIZ, C. A. R.; POLI, P. |
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Afiliação: |
Vera Lúcia Scherholz Salgado de Castro, Embrapa Meio Ambiente; Camila R. Destefani, UFSCAR; Carlos Diniz, UFSCAR; Paola Poli, Università degli Studi di Parma. |
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Título: |
Evaluation of neurodevelopmental effects on rats exposed prenatally to sulfentrazone. |
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Ano de publicação: |
2007 |
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Fonte/Imprenta: |
Neurotoxicology, Little Rock, v. 28, n. 6, p. 1249-1259, 2007. |
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Idioma: |
Inglês |
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Conteúdo: |
Although some studies have pointed to embryo/fetal toxicity at treatment levels that were not maternally toxic, knowledge about the potential toxic effects of the herbicide sulfentrazone is still limited. Since the results of these studies have raised some concern, the present work studied the effects of sulfentrazone maternal exposure on the physical and neurobehavioral endpoints in the development of rat pups. To accomplish that, the effects of the herbicide sulfentrazone (25 and 50mg/kg) were examined at two different developmental stages in rats: during the first 6 days of gestation, or in the organogenesis period (6-15 days). After parturition, pups were tested in a developmental test battery including measures of growth, maturational milestones, and neurobehavioral development. Maternal exposure to the herbicide resulted in significant alterations of the postnatal age at which the developmental milestones of ear and eye opening and testes descent were observed. There was a reduced weight gain rate in pups and their mothers when treated during the gestational period at the highest dose tested. Also, the functional state of the rat pup nervous system at different stages of postnatal development showed some neurodevelopmental delays in righting reflex, negative geotaxis, grip response, and motor coordination-locomotion and rearing (21-90 days of life) in the treated groups. Herbicide genotoxicity was investigated in fresh leukocytes both in mothers and pups using the comet assay: the data did not show any significant genotoxic effect induced by the herbicide. The findings of this study emphasize that sulfentrazone maternal exposure may lead to some neuromuscular and behavioral deficits in nursing pups. MenosAlthough some studies have pointed to embryo/fetal toxicity at treatment levels that were not maternally toxic, knowledge about the potential toxic effects of the herbicide sulfentrazone is still limited. Since the results of these studies have raised some concern, the present work studied the effects of sulfentrazone maternal exposure on the physical and neurobehavioral endpoints in the development of rat pups. To accomplish that, the effects of the herbicide sulfentrazone (25 and 50mg/kg) were examined at two different developmental stages in rats: during the first 6 days of gestation, or in the organogenesis period (6-15 days). After parturition, pups were tested in a developmental test battery including measures of growth, maturational milestones, and neurobehavioral development. Maternal exposure to the herbicide resulted in significant alterations of the postnatal age at which the developmental milestones of ear and eye opening and testes descent were observed. There was a reduced weight gain rate in pups and their mothers when treated during the gestational period at the highest dose tested. Also, the functional state of the rat pup nervous system at different stages of postnatal development showed some neurodevelopmental delays in righting reflex, negative geotaxis, grip response, and motor coordination-locomotion and rearing (21-90 days of life) in the treated groups. Herbicide genotoxicity was investigated in fresh leukocytes both in mothers and pups using the come... Mostrar Tudo |
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Palavras-Chave: |
Coordenação motora; Sistema nervoso central; Teste. |
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Thesagro: |
Cobaia; Herbicida; Rato; Toxicologia; Toxidez. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02425naa a2200253 a 4500
001 1015559
005 2014-03-25
008 2007 bl uuuu u00u1 u #d
100 1 $aCASTRO, V. L. S. S. de
245 $aEvaluation of neurodevelopmental effects on rats exposed prenatally to sulfentrazone.
260 $c2007
520 $aAlthough some studies have pointed to embryo/fetal toxicity at treatment levels that were not maternally toxic, knowledge about the potential toxic effects of the herbicide sulfentrazone is still limited. Since the results of these studies have raised some concern, the present work studied the effects of sulfentrazone maternal exposure on the physical and neurobehavioral endpoints in the development of rat pups. To accomplish that, the effects of the herbicide sulfentrazone (25 and 50mg/kg) were examined at two different developmental stages in rats: during the first 6 days of gestation, or in the organogenesis period (6-15 days). After parturition, pups were tested in a developmental test battery including measures of growth, maturational milestones, and neurobehavioral development. Maternal exposure to the herbicide resulted in significant alterations of the postnatal age at which the developmental milestones of ear and eye opening and testes descent were observed. There was a reduced weight gain rate in pups and their mothers when treated during the gestational period at the highest dose tested. Also, the functional state of the rat pup nervous system at different stages of postnatal development showed some neurodevelopmental delays in righting reflex, negative geotaxis, grip response, and motor coordination-locomotion and rearing (21-90 days of life) in the treated groups. Herbicide genotoxicity was investigated in fresh leukocytes both in mothers and pups using the comet assay: the data did not show any significant genotoxic effect induced by the herbicide. The findings of this study emphasize that sulfentrazone maternal exposure may lead to some neuromuscular and behavioral deficits in nursing pups.
650 $aCobaia
650 $aHerbicida
650 $aRato
650 $aToxicologia
650 $aToxidez
653 $aCoordenação motora
653 $aSistema nervoso central
653 $aTeste
700 1 $aDESTEFANI, C. R.
700 1 $aDINIZ, C. A. R.
700 1 $aPOLI, P.
773 $tNeurotoxicology, Little Rock$gv. 28, n. 6, p. 1249-1259, 2007.
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| 2. |  | POLESI, L. G.; FRAGA, H. P. F. de; VIEIRA, L. do N.; HERINGER, A. S.; ORNELLAS, T. S.; SANTOS, H. P. dos; GUERRA, M. P.; PESCADOR, R. Chloroplast ultrastructure and hormone endogenous levels are differently affected under light and dark conditions during in vitro culture of Guadua chacoensis (Rojas) Londoño & P. M. Peterson. Acta Physiologiae Plantarum , v. 41, n. 10, p. 1-12, Jan. 2019.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
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