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 | Acesso ao texto completo restrito à biblioteca da Embrapa Meio Ambiente. Para informações adicionais entre em contato com cnpma.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Meio Ambiente. |
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Data corrente: |
27/05/1994 |
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Data da última atualização: |
28/12/2016 |
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Autoria: |
CASTRO, V. L. S. S. de; PALERMO-NETO, J. |
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Afiliação: |
VERA LUCIA SCHERHOLZ S DE CASTRO, CNPMA; J. PALERMO-NETO, USP. |
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Título: |
Effects of long-term aldrin administration on seizure susceptibility of rats. |
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Ano de publicação: |
1989 |
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Fonte/Imprenta: |
Pharmacology & Toxicology, v.65, p.204-208, 1989. |
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Idioma: |
Inglês |
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Conteúdo: |
The effects of long-term administration of sub-convulsive doses of aldrin, an organochlorinated pesticide, on seizure susceptibility of rats were studied. Results show that treatment with the pesticide made the rats more susceptible to sound-induced seizure; an increment in post-seizure depression time after maximal electroschock administration was also observed in aldrin-treated animals. Aldrin administration displaced the control dose-response curves constructed for amphetamine and pentylenetetrazol to the left and right, respectively; no differences were detected between control and aldrin-treated rats for strychnine, picrotoxin or 3-mercaptopropionic acid. The results, discussed in the light of the effects of aldrin on biogenic amines or on the electrophysiology of neurones suggested an involvement of both noradrenergic and alteration excitability of the CNS with the observed increments on seizure susceptibility. |
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Palavras-Chave: |
Insecticide; Organochloride; Pesticide; Rat. |
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Thesagro: |
Aldrin. |
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Thesaurus Nal: |
toxicology. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 01500naa a2200205 a 4500
001 1011947
005 2016-12-28
008 1989 bl uuuu u00u1 u #d
100 1 $aCASTRO, V. L. S. S. de
245 $aEffects of long-term aldrin administration on seizure susceptibility of rats.$h[electronic resource]
260 $c1989
520 $aThe effects of long-term administration of sub-convulsive doses of aldrin, an organochlorinated pesticide, on seizure susceptibility of rats were studied. Results show that treatment with the pesticide made the rats more susceptible to sound-induced seizure; an increment in post-seizure depression time after maximal electroschock administration was also observed in aldrin-treated animals. Aldrin administration displaced the control dose-response curves constructed for amphetamine and pentylenetetrazol to the left and right, respectively; no differences were detected between control and aldrin-treated rats for strychnine, picrotoxin or 3-mercaptopropionic acid. The results, discussed in the light of the effects of aldrin on biogenic amines or on the electrophysiology of neurones suggested an involvement of both noradrenergic and alteration excitability of the CNS with the observed increments on seizure susceptibility.
650 $atoxicology
650 $aAldrin
653 $aInsecticide
653 $aOrganochloride
653 $aPesticide
653 $aRat
700 1 $aPALERMO-NETO, J.
773 $tPharmacology & Toxicology$gv.65, p.204-208, 1989.
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Embrapa Meio Ambiente (CNPMA) |
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| 1. |  | VERZIGNASSI, J. R.; MACHINSKI, L. A. P.; JESUS, L. de; TISSIANI, I. M.; NICOLODI, R.; TORRES, M. L.; FERNANDES, C. D.; MIRANDA, J. C. P. de; PAIVA, A. S.; MAFRA, T. P. T.; BASSO, J. N.; QUETEZ, F. A. Viabilidade de sementes de Brachiaria ruziziensis pelo teste de tetrazólio. Informativo ABRATES, Londrina, v. 21, n. 2, ago. 2011. Edição dos Anais do XVII Congresso Brasileiro de Sementes., Natal, ago. 2011. 1 p.| Tipo: Resumo em Anais de Congresso |
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