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 | Acesso ao texto completo restrito à biblioteca da Embrapa Agroindústria Tropical. Para informações adicionais entre em contato com cnpat.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Agroindústria Tropical. |
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Data corrente: |
08/12/2025 |
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Data da última atualização: |
10/06/2026 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SILVEIRA, M. J. C. B.; CABRAL, V. P. DE F.; RODRIGUES, D. S.; MOREIRA, L. E. A.; COSTA, E. R. M. DA; LEITÃO, A. C.; FERREIRA, T. L.; SÁ, L. G. DO A. V.; ANDRADE NETO, J. B. DE; SILVA, C. R. DA; MORAES, M. O. DE; CAVALCANTI, B. C.; MAGALHÃES, I. L.; MORAIS, S. M. de; ALVES, D. R.; PINHEIRO, S. DE O.; SILVA, W. M. B. DA; RIBEIRO, P. R. V.; CANUTO, K. M.; NOBRE JÚNIOR, H. V. |
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Afiliação: |
MARIA JANIELLY CASTELO BRANCO SILVEIRA, FEDERAL UNIVERSITY OF CEARÁ; VITÓRIA PESSOA DE FARIAS CABRAL, FEDERAL UNIVERSITY OF CEARÁ; DANIEL SAMPAIO RODRIGUES, FEDERAL UNIVERSITY OF CEARÁ; LARA ELLOYSE ALMEIDA MOREIRA, FEDERAL UNIVERSITY OF CEARÁ; ÉRICA RAYANNE MOTA DA COSTA, FEDERAL UNIVERSITY OF CEARÁ; AMANDA CAVALCANTE LEITÃO, FEDERAL UNIVERSITY OF CEARÁ; THAÍS LIMA FERREIRA, FEDERAL UNIVERSITY OF CEARÁ; LÍVIA GURGEL DO AMARAL VALENTE SÁ, FEDERAL UNIVERSITY OF CEARÁ; JOÃO BATISTA DE ANDRADE NETO, CHRISTUS UNIVERSITY CENTER; CECÍLIA ROCHA DA SILVA, FEDERAL UNIVERSITY OF CEARÁ; MANOEL ODORICO DE MORAES, FEDERAL UNIVERSITY OF CEARÁ; BRUNO COELHO CAVALCANTI, FEDERAL UNIVERSITY OF CEARÁ; ISLAY LIMA MAGALHÃES, FEDERAL UNIVERSITY OF CEARÁ; SELENE MAIA DE MORAIS, STATE UNIVERSITY OF CEARA; DANIELA RIBEIRO ALVES, STATE UNIVERSITY OF CEARÁ; SOLANGE DE OLIVEIRA PINHEIRO, STATE UNIVERSITY OF CEARÁ; WILDSON MAX BARBOSA DA SILVA, STATE UNIVERSITY OF VALE DO ACARAÚ; PAULO RICELI VASCONCELOS RIBEIRO, CNPAT; KIRLEY MARQUES CANUTO, CNPAT; HÉLIO VITORIANO NOBRE JÚNIOR, FEDERAL UNIVERSITY OF CEARÁ. |
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Título: |
Chemical characterization and in vitro evaluation of the antifungal activity of Caryocar coriaceum Wittm. extracts against Candida spp. and their potential mechanisms of action. |
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Ano de publicação: |
2025 |
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Fonte/Imprenta: |
Microbial Pathogenesis, 208, 108031, 2025. |
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DOI: |
https://doi.org/10.1016/j.micpath.2025.108031 |
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Idioma: |
Inglês |
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Conteúdo: |
The increase in antifungal resistance requires finding alternatives to combat fungal infections, particularly those caused by species of the Candida genus. Caryocar spp., known as pequi, is a plant used in traditional medicine for its anti-inflammatory, antimicrobial and wound-healing properties. We analyzed the chemical composition and evaluated the activity of three extracts of C. coriaceum Wittm. against Candida spp. strains in both their plank- tonic and biofilm forms, and investigated their possible mechanisms of action. The results demonstrated anti- fungal activity of the leaf extracts against Candida spp. strains, with minimum inhibitory concentrations ranging from 0.5 to 512 μ g/mL, although with limited effect on biofilms. Ultra-performance liquid chromatography analysis identified four main classes of compounds: flavonoids, hydrolyzable tannins, carboxylic acids, and hydroxy acids. Mechanistic analysis indicated the generation of reactive oxygen species, mitochondrial depo- larization, DNA damage, and reduced cell density due to the induction of apoptosis. The extracts exhibited low cytotoxicity toward human lymphocytes. Furthermore, a synergistic effect was observed when the extracts were combined with amphotericin B, revealing a potentially synergistic association against Candida infections. |
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Palavras-Chave: |
Cândida Anfotericina B; Espécies reativas de oxigênio; Sinergismo medicamentoso. |
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Thesagro: |
Pequi. |
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Thesaurus Nal: |
Amphotericin B; Candida; Caryocar; Drug synergism; Reactive oxygen species. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02811naa a2200469 a 4500
001 2182519
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008 2025 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.micpath.2025.108031$2DOI
100 1 $aSILVEIRA, M. J. C. B.
245 $aChemical characterization and in vitro evaluation of the antifungal activity of Caryocar coriaceum Wittm. extracts against Candida spp. and their potential mechanisms of action.$h[electronic resource]
260 $c2025
520 $aThe increase in antifungal resistance requires finding alternatives to combat fungal infections, particularly those caused by species of the Candida genus. Caryocar spp., known as pequi, is a plant used in traditional medicine for its anti-inflammatory, antimicrobial and wound-healing properties. We analyzed the chemical composition and evaluated the activity of three extracts of C. coriaceum Wittm. against Candida spp. strains in both their plank- tonic and biofilm forms, and investigated their possible mechanisms of action. The results demonstrated anti- fungal activity of the leaf extracts against Candida spp. strains, with minimum inhibitory concentrations ranging from 0.5 to 512 μ g/mL, although with limited effect on biofilms. Ultra-performance liquid chromatography analysis identified four main classes of compounds: flavonoids, hydrolyzable tannins, carboxylic acids, and hydroxy acids. Mechanistic analysis indicated the generation of reactive oxygen species, mitochondrial depo- larization, DNA damage, and reduced cell density due to the induction of apoptosis. The extracts exhibited low cytotoxicity toward human lymphocytes. Furthermore, a synergistic effect was observed when the extracts were combined with amphotericin B, revealing a potentially synergistic association against Candida infections.
650 $aAmphotericin B
650 $aCandida
650 $aCaryocar
650 $aDrug synergism
650 $aReactive oxygen species
650 $aPequi
653 $aCândida Anfotericina B
653 $aEspécies reativas de oxigênio
653 $aSinergismo medicamentoso
700 1 $aCABRAL, V. P. DE F.
700 1 $aRODRIGUES, D. S.
700 1 $aMOREIRA, L. E. A.
700 1 $aCOSTA, E. R. M. DA
700 1 $aLEITÃO, A. C.
700 1 $aFERREIRA, T. L.
700 1 $aSÁ, L. G. DO A. V.
700 1 $aANDRADE NETO, J. B. DE
700 1 $aSILVA, C. R. DA
700 1 $aMORAES, M. O. DE
700 1 $aCAVALCANTI, B. C.
700 1 $aMAGALHÃES, I. L.
700 1 $aMORAIS, S. M. de
700 1 $aALVES, D. R.
700 1 $aPINHEIRO, S. DE O.
700 1 $aSILVA, W. M. B. DA
700 1 $aRIBEIRO, P. R. V.
700 1 $aCANUTO, K. M.
700 1 $aNOBRE JÚNIOR, H. V.
773 $tMicrobial Pathogenesis, 208, 108031, 2025.
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| 1. |  | CAMARGO, P. M. P.; BRASIL, E. C. Avaliar o impacto da tecnologia de corte e trituração sobre a dinâmica da matéria orgânica (Mo) do solo em longo prazo, através da quantificação e caracterização de diferentes compartimentos orgânicos do solo. In: SEMINÁRIO DE INICIAÇÃO CIENTÍFICA DA UFRA, 3.; SEMINÁRIO DE INICIAÇÃO CIENTÍFICA DA EMBRAPA AMAZÔNIA ORIENTAL, 9., 2006, Belém, PA. Agricultura sustentável na Amazônia: anais. Belém, PA: UFRA: Embrapa Amazônia Oriental, 2006.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Amazônia Oriental. |
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