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Registro Completo |
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Biblioteca(s): |
Embrapa Agroindústria Tropical. |
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Data corrente: |
13/05/2025 |
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Data da última atualização: |
13/05/2025 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
ROSA, M. E. P.; REBOUÇAS, L. M.; MARQUES, S. P. D.; SILVA, L. M. R.; CUNHA, F. E. T.; COSTA, P. M. S.; ASSIS, D. A. DE; SILVEIRA, K. B.; MUNIZ, C. R.; TREVISAN, M. T. S.; PESSOA, C.; RICARDO, N. M. P. S. |
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Afiliação: |
MARLON E. P. ROSA, FEDERAL UNIVERSITY OF CEARA; LOUHANA M. REBOUÇAS, FEDERAL UNIVERSITY OF CEARA; SAMUEL P. D. MARQUES, FEDERAL UNIVERSITY OF CEARA; LARISSA M. R. SILVA, FEDERAL UNIVERSITY OF CEARA; FERNANDO E. T. CUNHA, FEDERAL UNIVERSITY OF CEARA; PEDRO M. S. COSTA, FEDERAL UNIVERSITY OF CEARA; DAVID A. DE ASSIS, FEDERAL UNIVERSITY OF CEARA; KAMILLA B. SILVEIRA, FEDERAL INSTITUTE OF EDUCATION, SCIENCE AND TECHNOLOGY OF SERTÃO PERNAMBUCANO; CELLI RODRIGUES MUNIZ, CNPAT; MARIA T. S. TREVISAN, FEDERAL UNIVERSITY OF CEARÁ; CLÁUDIA PESSOA, FEDERAL UNIVERSITY OF CEARÁ; NÁGILA M. P. S. RICARDO, FEDERAL UNIVERSITY OF CEARÁ. |
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Título: |
Sodium hyaluronate microcapsules to promote antitumor selectivity of anacardic acid. |
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Ano de publicação: |
2025 |
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Fonte/Imprenta: |
International Journal of Biological Macromolecules, 296, 139616, 2025. |
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DOI: |
https://doi.org/10.1016/j.ijbiomac.2025.139616 |
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Idioma: |
Inglês |
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Conteúdo: |
Anacardic acid (AA) is a phenolic lipid extracted from cashew nutshell liquid that has antitumor activity. Given the high hydrophobicity of this compound and aiming to create efficient vehicle for its administration in aqueous systems, the objective of the present work was to develop a microcapsule (MCAA) by spray dryer technique, based on the polysaccharide sodium hyaluronate (SH), containing AA as its core, encapsulated from nano- emulsion. The Encapsulation Efficiency of MCAA presented a value equal to 95.06 ± 1.22 %. In vitro release kinetic study showed a pH-responsive release, with greater release of AA from MCAA at pH 6.8 and 7.4 and almost none at pH 4.5, which prevents its delivery to the cellular lysosome. Tests on zebrafish did not show acute toxicity within 96 h or change in locomotor activity. The IC50 determined in the MTT assay for the formulation presented values of 30.1 and 29.8 μ g mL 1 in HCT-116 and HL-60 cells, respectively, and did not present a detectable IC50 in the concentration range tested for non-tumoral L-929 cells. Thus, encapsulation with sodium hyaluronate polysaccharide allowed a reduced toxicity in these cells compared to non-encapsulated AA (IC50 = 0.70 μ g mL 1, in L-929), maintaining the inhibition of cancer cell growth. These results suggest adverse effects reduction, making MCAA promising for future applications in antineoplastic therapies. |
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Palavras-Chave: |
Ácido anacárdico; Anacardic acid; Anticancer; Anticancerígeno; Hialuronato de sódio; Microcápsulas; Microcapsules; Sodium hyaluronate. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02489naa a2200361 a 4500
001 2175552
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008 2025 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.ijbiomac.2025.139616$2DOI
100 1 $aROSA, M. E. P.
245 $aSodium hyaluronate microcapsules to promote antitumor selectivity of anacardic acid.$h[electronic resource]
260 $c2025
520 $aAnacardic acid (AA) is a phenolic lipid extracted from cashew nutshell liquid that has antitumor activity. Given the high hydrophobicity of this compound and aiming to create efficient vehicle for its administration in aqueous systems, the objective of the present work was to develop a microcapsule (MCAA) by spray dryer technique, based on the polysaccharide sodium hyaluronate (SH), containing AA as its core, encapsulated from nano- emulsion. The Encapsulation Efficiency of MCAA presented a value equal to 95.06 ± 1.22 %. In vitro release kinetic study showed a pH-responsive release, with greater release of AA from MCAA at pH 6.8 and 7.4 and almost none at pH 4.5, which prevents its delivery to the cellular lysosome. Tests on zebrafish did not show acute toxicity within 96 h or change in locomotor activity. The IC50 determined in the MTT assay for the formulation presented values of 30.1 and 29.8 μ g mL 1 in HCT-116 and HL-60 cells, respectively, and did not present a detectable IC50 in the concentration range tested for non-tumoral L-929 cells. Thus, encapsulation with sodium hyaluronate polysaccharide allowed a reduced toxicity in these cells compared to non-encapsulated AA (IC50 = 0.70 μ g mL 1, in L-929), maintaining the inhibition of cancer cell growth. These results suggest adverse effects reduction, making MCAA promising for future applications in antineoplastic therapies.
653 $aÁcido anacárdico
653 $aAnacardic acid
653 $aAnticancer
653 $aAnticancerígeno
653 $aHialuronato de sódio
653 $aMicrocápsulas
653 $aMicrocapsules
653 $aSodium hyaluronate
700 1 $aREBOUÇAS, L. M.
700 1 $aMARQUES, S. P. D.
700 1 $aSILVA, L. M. R.
700 1 $aCUNHA, F. E. T.
700 1 $aCOSTA, P. M. S.
700 1 $aASSIS, D. A. DE
700 1 $aSILVEIRA, K. B.
700 1 $aMUNIZ, C. R.
700 1 $aTREVISAN, M. T. S.
700 1 $aPESSOA, C.
700 1 $aRICARDO, N. M. P. S.
773 $tInternational Journal of Biological Macromolecules, 296, 139616, 2025.
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