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Registro Completo |
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Biblioteca(s): |
Embrapa Recursos Genéticos e Biotecnologia. |
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Data corrente: |
23/01/2025 |
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Data da última atualização: |
23/01/2025 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
ADAMALA, K. P.; AGASHE, D.; BELKAID, Y.; BITTENCOURT, D. M. de C.; CAI, Y.; CHANG, M. W.; CHEN, I. A.; CHURCH, G. M.; COOPER, V. S.; DAVIS, M. M.; DEVARAJ, N. K.; ENDY, D.; ESVELT, K. M.; GLASS, J. I.; HAND, T. W.; INGLESBY, T. V.; ISAACS, F. J.; JAMES, W. G.; JONES, J. D. G.; KAY, M. S.; LENSKI, R. E.; LIU, C.; MEDZHITOV, R.; NICOTRA, M. L.; OEHM, S. B.; PANNU, J.; RELMAN, D. A.; SCHWILLE, P.; SMITH, J. A.; SUGA, H.; SZOSTAK, J. W.; TALBOT, N. J.; TIEDJE, J. M.; VENTER, J. C.; WINTER, G.; ZHANG, W.; ZHU, X.; ZUBER, M. T. |
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Afiliação: |
KATARZYNA P. ADAMALA; DEEPA AGASHE; YASMINE BELKAID; DANIELA MATIAS DE C BITTENCOURT, CENARGEN; YIZHI CAI; MATTHEW W. CHANG; IRENE A. CHEN; GEORGE M. CHURCH; VAUGHN S. COOPER; MARK M. DAVIS; NEAL K. DEVARAJ; DREW ENDY; KEVIN M. ESVELT; JOHN I. GLASS; TIMOTHY W. HAND; THOMAS V. INGLESBY; FARREN J. ISAACS; WILMOT G. JAMES; JONATHAN D. G. JONES; MICHAEL S. KAY; RICHARD E. LENSKI; CHENLI LIU; RUSLAN MEDZHITOV; MATTHEW L. NICOTRA; SEBASTIAN B. OEHM; JASPREET PANNU; DAVID A. RELMAN; PETRA SCHWILLE; JAMES A. SMITH; HIROAKI SUGA; JACK W. SZOSTAK; NICHOLAS J. TALBOT; JAMES M. TIEDJE; J. CRAIG VENTER; GREGORY WINTER; WEIWEN ZHANG; XINGUANG ZHU; MARIA T. ZUBER. |
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Título: |
Confronting risks of mirror life. |
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Ano de publicação: |
2024 |
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Fonte/Imprenta: |
Science, v, 386, n. 6728, p. 1351-1353, 2024. |
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DOI: |
10.1126/science.ads9158 |
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Idioma: |
Inglês |
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Conteúdo: |
All known life is homochiral. DNA and RNA are made from “righthanded” nucleotides, and proteins are made from “left-handed” amino acids. Driven by curiosity and plausible applications, some researchers had begun work toward creating lifeforms composed entirely of mirror-image biological molecules. Such mirror organisms would constitute a radical departure from known life, and their creation warrants careful consideration. The capability to create mirror life is likely at least a decade away and would require large investments and major technical advances; we thus have an opportunity to consider and preempt risks before they are realized. Here, we draw on an indepth analysis of current technical barriers, how they might be eroded by technological progress, and what we deem to be unprecedented and largely overlooked risks (1). We call for broader discussion among the global research community, policy-makers, research funders, industry, civil society, and the public to chart an appropriate path forward. |
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Palavras-Chave: |
Mirror organisms; Mirror-image biological molecules. |
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Categoria do assunto: |
-- |
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Marc: |
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008 2024 bl uuuu u00u1 u #d
024 7 $a10.1126/science.ads9158$2DOI
100 1 $aADAMALA, K. P.
245 $aConfronting risks of mirror life.$h[electronic resource]
260 $c2024
520 $aAll known life is homochiral. DNA and RNA are made from “righthanded” nucleotides, and proteins are made from “left-handed” amino acids. Driven by curiosity and plausible applications, some researchers had begun work toward creating lifeforms composed entirely of mirror-image biological molecules. Such mirror organisms would constitute a radical departure from known life, and their creation warrants careful consideration. The capability to create mirror life is likely at least a decade away and would require large investments and major technical advances; we thus have an opportunity to consider and preempt risks before they are realized. Here, we draw on an indepth analysis of current technical barriers, how they might be eroded by technological progress, and what we deem to be unprecedented and largely overlooked risks (1). We call for broader discussion among the global research community, policy-makers, research funders, industry, civil society, and the public to chart an appropriate path forward.
653 $aMirror organisms
653 $aMirror-image biological molecules
700 1 $aAGASHE, D.
700 1 $aBELKAID, Y.
700 1 $aBITTENCOURT, D. M. de C.
700 1 $aCAI, Y.
700 1 $aCHANG, M. W.
700 1 $aCHEN, I. A.
700 1 $aCHURCH, G. M.
700 1 $aCOOPER, V. S.
700 1 $aDAVIS, M. M.
700 1 $aDEVARAJ, N. K.
700 1 $aENDY, D.
700 1 $aESVELT, K. M.
700 1 $aGLASS, J. I.
700 1 $aHAND, T. W.
700 1 $aINGLESBY, T. V.
700 1 $aISAACS, F. J.
700 1 $aJAMES, W. G.
700 1 $aJONES, J. D. G.
700 1 $aKAY, M. S.
700 1 $aLENSKI, R. E.
700 1 $aLIU, C.
700 1 $aMEDZHITOV, R.
700 1 $aNICOTRA, M. L.
700 1 $aOEHM, S. B.
700 1 $aPANNU, J.
700 1 $aRELMAN, D. A.
700 1 $aSCHWILLE, P.
700 1 $aSMITH, J. A.
700 1 $aSUGA, H.
700 1 $aSZOSTAK, J. W.
700 1 $aTALBOT, N. J.
700 1 $aTIEDJE, J. M.
700 1 $aVENTER, J. C.
700 1 $aWINTER, G.
700 1 $aZHANG, W.
700 1 $aZHU, X.
700 1 $aZUBER, M. T.
773 $tScience, v, 386$gn. 6728, p. 1351-1353, 2024.
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