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 | Acesso ao texto completo restrito à biblioteca da Embrapa Amazônia Ocidental. Para informações adicionais entre em contato com cpaa.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Amazônia Ocidental. |
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Data corrente: |
30/11/2024 |
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Data da última atualização: |
04/02/2025 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
OLIVEIRA, C. M. da S. C. de; BASSICHETO, M. C.; BARBOSA, R. S.; NEVES, K. de O. G.; MONTEIRO, C. dos S.; UEMI, M.; PASCON, R. C.; SILVA, G. F. da; KOOLEN, H. H. F.; MEDEIROS, L. S. de. |
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Afiliação: |
CLÁUDIA MARIA DA SILVA COSTA DE OLIVEIRA, UNIVERSIDADE FEDERAL DE SÃO PAULO; MILENA COSTA BASSICHETO, UNIVERSIDADE FEDERAL DE SÃO PAULO; RENAN SANTINI BARBOSA, UNIVERSIDADE FEDERAL DE SÃO PAULO; KIANDRO DE OLIVEIRA GOMES NEVES, UNIVERSIDADE DO ESTADO DO AMAZONAS; CAROLINE DOS SANTOS MONTEIRO, UNIVERSIDADE FEDERAL DE SÃO PAULO; MIRIAM UEMI, UNIVERSIDADE FEDERAL DE SÃO PAULO; RENATA CASTIGLIONI PASCON, UNIVERSIDADE FEDERAL DE SÃO PAULO; GILVAN FERREIRA DA SILVA, CPAA; HECTOR HENRIQUE FERREIRA KOOLEN, UNIVERSIDADE DO ESTADO DO AMAZONAS; LÍVIA SOMAN DE MEDEIROS, UNIVERSIDADE FEDERAL DE SÃO PAULO. |
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Título: |
Integrated workflows using metabolomics, genome mining, and biological evaluation reveal oxepine‑sulfur-containing anti-cryptococcal diketopiperazine produced by the endophyte Penicillium setosum. |
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Ano de publicação: |
2025 |
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Fonte/Imprenta: |
Fitoterapia, v. 180, 106301, Jan. 2025. |
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DOI: |
https://doi.org/10.1016/j.fitote.2024.106301 |
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Idioma: |
Inglês |
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Conteúdo: |
Cryptococcosis is a fungal infection for which treatment relies on old antifungal agents usually leading to drawbacks such as high toxicity and mainly low efficiency since drug resistance of microorganisms is strongly widespread. The discovery of new antifungal agents is urgent and investigations about underexplored Natural Product (NP) can yield the necessary outcomes to guide the discovery of new prototypes to anti-cryptococcal molecules development. In this scenario, an integrated strategy involving metabolomic data analysis, biological assessement and genome mining of P. setosum CMLD 18, revealed the biosynthesis of bis(methyl-sulfanyl) oxepine-containing diketopiperazine derivative, the bisdethiobis(methylthio)acetylaranotine (1) by the endophyte. The molecule showed a minimum inhibitory concentration (MIC) value of 0.125 mM when tested against C. neoformans. Evidence about the corresponding biosynthetic gene cluster (BGC) responsible for the biosynthesis of (1) in P. setosum were found. Moreover, other putative analogues of (1) were also detected, suggesting this microorganism may represent an important source of likely anti-cryptococcal molecules to be further investigated. |
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Palavras-Chave: |
Anti-cryptococcal; Diketopiperazine; Penicillium setosum. |
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Thesaurus Nal: |
Genome mining. |
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Categoria do assunto: |
-- |
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Marc: |
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100 1 $aOLIVEIRA, C. M. da S. C. de
245 $aIntegrated workflows using metabolomics, genome mining, and biological evaluation reveal oxepine‑sulfur-containing anti-cryptococcal diketopiperazine produced by the endophyte Penicillium setosum.$h[electronic resource]
260 $c2025
520 $aCryptococcosis is a fungal infection for which treatment relies on old antifungal agents usually leading to drawbacks such as high toxicity and mainly low efficiency since drug resistance of microorganisms is strongly widespread. The discovery of new antifungal agents is urgent and investigations about underexplored Natural Product (NP) can yield the necessary outcomes to guide the discovery of new prototypes to anti-cryptococcal molecules development. In this scenario, an integrated strategy involving metabolomic data analysis, biological assessement and genome mining of P. setosum CMLD 18, revealed the biosynthesis of bis(methyl-sulfanyl) oxepine-containing diketopiperazine derivative, the bisdethiobis(methylthio)acetylaranotine (1) by the endophyte. The molecule showed a minimum inhibitory concentration (MIC) value of 0.125 mM when tested against C. neoformans. Evidence about the corresponding biosynthetic gene cluster (BGC) responsible for the biosynthesis of (1) in P. setosum were found. Moreover, other putative analogues of (1) were also detected, suggesting this microorganism may represent an important source of likely anti-cryptococcal molecules to be further investigated.
650 $aGenome mining
653 $aAnti-cryptococcal
653 $aDiketopiperazine
653 $aPenicillium setosum
700 1 $aBASSICHETO, M. C.
700 1 $aBARBOSA, R. S.
700 1 $aNEVES, K. de O. G.
700 1 $aMONTEIRO, C. dos S.
700 1 $aUEMI, M.
700 1 $aPASCON, R. C.
700 1 $aSILVA, G. F. da
700 1 $aKOOLEN, H. H. F.
700 1 $aMEDEIROS, L. S. de
773 $tFitoterapia$gv. 180, 106301, Jan. 2025.
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Embrapa Amazônia Ocidental (CPAA) |
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| 1. |  | FERREIRA, C. R.; BURGSTALLER, J. P.; PERECIN, F.; GARCIA, J. M.; CHIARATTI, M. R.; MÉO, S. C.; MULLER, M.; SMITH, L. C.; MEIRELLES, F. V.; STEINBORN, R. Pronounced segregation of donor mitochondria introduced by bovine Ooplasmic tranfer to the female germ-line. Biology of Reproduction, v. 82, n. 03, p. 563-571, mar. 2010.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
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