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Registro Completo |
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Biblioteca(s): |
Embrapa Instrumentação. |
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Data corrente: |
21/12/2023 |
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Data da última atualização: |
27/11/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
DORM, B. C.; PARIS JUNIOR, J. A.; SILVA, L. H. D. da; FORATO, L. A.; NOSSA, T. S.; CARVALHO, A. J. F.; RESENDE, F. A.; GANDINI, A.; TROVATTI, E. |
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Afiliação: |
BRUNA CAROLINA DORM, UNIVERSIDADE DE ARARAQUARA (UNIARA); JOSÉ ALBERTO PARIS JUNIOR, UNIVERSIDADE DE ARARAQUARA (UNIARA); LUCAS HENRIQUE DOMINGOS DA SILVA, UNIVERSIDADE DE FRANCA (UNIFRAN); LUCIMARA APARECIDA FORATO, CNPDIA; TAMIRES DE SOUZA NOSSA, INSTITUTO FEDERAL DE EDUCAÇÃO, CIÊNCIA E TECNOLOGIA DE SÃO PAULO (IFSP); ANTONIO JOSÉ FELIX CARVALHO, UNIVERSIDADE DE SÃO PAULO (USP); FLÁVIA APARECIDA RESENDE, UNIVERSIDADE DE ARARAQUARA (UNIARA); ALESSANDRO GANDINI, UNIVERSIDADE DE SÃO PAULO; ELIANE TROVATTI, UNIVERSIDADE DE ARARAQUARA (UNIARA). |
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Título: |
Synthesis of a cysteine Diels–Alder‑based polymer by simultaneous double‑click chemistry and its cyto‑genotoxicity evaluation. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Macromolecular Research, v. 32, n. 2, 2023. |
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Páginas: |
133-144 |
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ISSN: |
2092-7673 |
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DOI: |
https://doi.org/10.1007/s13233-023-00216-8 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract The click chemistry reactions and its use in living organisms have been widely developed; however, few studies describe the safety of the reagents and products. Furan–maleimide represent one important pair of reagents for the click Diels–Alder reaction, and were chosen here to perform the minimalist click reaction with cysteine to reveal their preliminary safety features by cytotoxicity tests. The functional groups of amino acids allow them to be chemically modifed, mainly for the synthesis of monomers and polymers. Here, cysteine was used in the click reaction, since it displays an SH group in its side chain, useful to perform thiol–ene reactions. Its amine group easily reacts with anhydrides, allowing it to couple with the furan derivative “furan–maleic anhydride adduct”. The mixture of the cysteine with the adduct in solution gives rise to the double simultaneous thiol–ene/amine maleimide click reactions. The thiol group and the furan double bond provide the reactive functional groups for the polymerization. The synthesis of the polymer based on cysteine–Diels–Alder adduct confrmed the condensation nature of the reaction. Preliminary safety and biocompatibility tests of this new polymer and its starting reagents were carried out, since these parameters represent one of the most important features for operating and scaling up the production. This one-step double-click reaction is interesting for application in several felds, since it has the advantage of using natural and renewable raw materials, in addition to its handling safety. MenosAbstract The click chemistry reactions and its use in living organisms have been widely developed; however, few studies describe the safety of the reagents and products. Furan–maleimide represent one important pair of reagents for the click Diels–Alder reaction, and were chosen here to perform the minimalist click reaction with cysteine to reveal their preliminary safety features by cytotoxicity tests. The functional groups of amino acids allow them to be chemically modifed, mainly for the synthesis of monomers and polymers. Here, cysteine was used in the click reaction, since it displays an SH group in its side chain, useful to perform thiol–ene reactions. Its amine group easily reacts with anhydrides, allowing it to couple with the furan derivative “furan–maleic anhydride adduct”. The mixture of the cysteine with the adduct in solution gives rise to the double simultaneous thiol–ene/amine maleimide click reactions. The thiol group and the furan double bond provide the reactive functional groups for the polymerization. The synthesis of the polymer based on cysteine–Diels–Alder adduct confrmed the condensation nature of the reaction. Preliminary safety and biocompatibility tests of this new polymer and its starting reagents were carried out, since these parameters represent one of the most important features for operating and scaling up the production. This one-step double-click reaction is interesting for application in several felds, since it has the advantage of using nat... Mostrar Tudo |
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Palavras-Chave: |
Diels–Alder; Renewable resource; Thiol-ene. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02466naa a2200289 a 4500
001 2160195
005 2024-11-27
008 2023 bl uuuu u00u1 u #d
022 $a2092-7673
024 7 $ahttps://doi.org/10.1007/s13233-023-00216-8$2DOI
100 1 $aDORM, B. C.
245 $aSynthesis of a cysteine Diels–Alder‑based polymer by simultaneous double‑click chemistry and its cyto‑genotoxicity evaluation.$h[electronic resource]
260 $c2023
300 $a133-144
520 $aAbstract The click chemistry reactions and its use in living organisms have been widely developed; however, few studies describe the safety of the reagents and products. Furan–maleimide represent one important pair of reagents for the click Diels–Alder reaction, and were chosen here to perform the minimalist click reaction with cysteine to reveal their preliminary safety features by cytotoxicity tests. The functional groups of amino acids allow them to be chemically modifed, mainly for the synthesis of monomers and polymers. Here, cysteine was used in the click reaction, since it displays an SH group in its side chain, useful to perform thiol–ene reactions. Its amine group easily reacts with anhydrides, allowing it to couple with the furan derivative “furan–maleic anhydride adduct”. The mixture of the cysteine with the adduct in solution gives rise to the double simultaneous thiol–ene/amine maleimide click reactions. The thiol group and the furan double bond provide the reactive functional groups for the polymerization. The synthesis of the polymer based on cysteine–Diels–Alder adduct confrmed the condensation nature of the reaction. Preliminary safety and biocompatibility tests of this new polymer and its starting reagents were carried out, since these parameters represent one of the most important features for operating and scaling up the production. This one-step double-click reaction is interesting for application in several felds, since it has the advantage of using natural and renewable raw materials, in addition to its handling safety.
653 $aDiels–Alder
653 $aRenewable resource
653 $aThiol-ene
700 1 $aPARIS JUNIOR, J. A.
700 1 $aSILVA, L. H. D. da
700 1 $aFORATO, L. A.
700 1 $aNOSSA, T. S.
700 1 $aCARVALHO, A. J. F.
700 1 $aRESENDE, F. A.
700 1 $aGANDINI, A.
700 1 $aTROVATTI, E.
773 $tMacromolecular Research$gv. 32, n. 2, 2023.
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| 16. |  | VILELA, D.; RODDEN, B.; OLIVEIRA, J. S. e. Avaliação da silagem de capim-elefante, acondicionada a vácuo em silos de superfície, utilizando-se novilhas em sistema de auto-alimentação. Pesquisa Agropecuaria Brasileira, Brasilia, v. 18, n. 6, p. 663-673, 1983.| Biblioteca(s): Embrapa Gado de Leite; Embrapa Unidades Centrais. |
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