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| Acesso ao texto completo restrito à biblioteca da Embrapa Caprinos e Ovinos. Para informações adicionais entre em contato com cnpc.biblioteca@embrapa.br. |
Registro Completo |
Biblioteca(s): |
Embrapa Agroindústria de Alimentos; Embrapa Caprinos e Ovinos. |
Data corrente: |
13/12/2023 |
Data da última atualização: |
13/12/2023 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
PEREIRA, A. M. de S.; LIMA, L. C. de A. S.; LIMA, L. W. S.; MENEZES, T. M.; VIEIRA, A. M.; FRANCO, E. de S.; PAZ, S. T.; MAIA, C. S.; EGITO, A. S. do; SANTOS, K. M. O. dos; BURITI, F. C. A.; MAIA, M. B. de S. |
Afiliação: |
ÁUREA MARCELA DE SOUZA PEREIRA, Federal University of Pernambuco; LARISSA CAROLINE DE ALMEIDA SOUSA LIMA, Federal University of Pernambuco; LAISA WANESSA SANTOS LIMA, Federal University of Pernambuco; TAMIRES MEIRA MENEZES, Federal University of Pernambuco; ÂNGELA MAGALHÃES VIEIRA, Aggeu Magalhães Institute, Oswaldo Cruz Foundation; ERYVELTON DE SOUZA FRANCO, Brazilian University Center (UNIBRA); SILVÂNIA TAVARES PAZ, Federal University of Pernambuco; CARINA SCANONI MAIA, Federal University of Pernambuco; ANTONIO SILVIO DO EGITO VASCONCELOS, CNPC; KARINA MARIA OLBRICH DOS SANTOS, CTAA; FLÁVIA CAROLINA ALONSO BURITI, State University of Paraíba; MARIA BERNADETE DE SOUSA MAIA, Federal University of Pernambuco. |
Título: |
Safety evaluation of goat milk added with the prebiotic inulin fermented with the potentially probiotic native culture Limosilactobacillus mucosae CNPC007 in co-culture with Streptococcus thermophilus QGE: analysis of acute and repeated dose oral toxicity. |
Ano de publicação: |
2023 |
Fonte/Imprenta: |
Probiotics Antimicrob Proteins, v. 15, n. 3, p. 716-727, 2023. |
DOI: |
https://doi.org/10.1007/s12602-021-09898-x |
Idioma: |
Inglês |
Conteúdo: |
Abstract: Despite functional goat milk products having emerged due to their importance for human nutrition and health, few studies have assessed the safety of consumption of goat dairy products containing potentially probiotic autochthonous lactic acid bacteria supplemented with prebiotic carbohydrates. Aiming this field, this study evaluated the safety of goat’s milk fermented with Streptococcus thermophilus QGE, the autochthonous Limosilactobacillus mucosae CNPC007 culture, and the prebiotic inulin, through single- and repeated-dose oral toxicity tests (SDT and RDT, respectively) in animals. Ten female Swiss Webster mice were used for SDT evaluation — 2 groups, SDTc (20 mL/kg of filtered water) and SDTt (20 mL/kg of fermented milk) — and 40 Wistar rats for RDT — RDT3, RDT6, and RDT12 (treated with fermented milk at doses of 3 mL/kg, 6 mL/kg, and 12 mL/kg, respectively) and also RDTc (12 mL/kg of filtered water). For SDT, no signs of mortality or toxicity were observed, and the animals maintained the expected weight gain and feed intake. The RDT trials did not show mortality or signs of toxicity, as well as no change in body weight and organs, in the hematological and biochemical parameters, and also in relation to morphology and histology. Since the fermented milk did not cause any toxic effect in the conditions evaluated, it can be said that its no-adverse effect level (NOAEL) was considered to be higher than 20 mL/kg/day. Thus, the fermented milk with L. mucosae CNPC007 and inulin was considered to be of low toxicity, safe for use in rodents, and allowed for use in further studies. MenosAbstract: Despite functional goat milk products having emerged due to their importance for human nutrition and health, few studies have assessed the safety of consumption of goat dairy products containing potentially probiotic autochthonous lactic acid bacteria supplemented with prebiotic carbohydrates. Aiming this field, this study evaluated the safety of goat’s milk fermented with Streptococcus thermophilus QGE, the autochthonous Limosilactobacillus mucosae CNPC007 culture, and the prebiotic inulin, through single- and repeated-dose oral toxicity tests (SDT and RDT, respectively) in animals. Ten female Swiss Webster mice were used for SDT evaluation — 2 groups, SDTc (20 mL/kg of filtered water) and SDTt (20 mL/kg of fermented milk) — and 40 Wistar rats for RDT — RDT3, RDT6, and RDT12 (treated with fermented milk at doses of 3 mL/kg, 6 mL/kg, and 12 mL/kg, respectively) and also RDTc (12 mL/kg of filtered water). For SDT, no signs of mortality or toxicity were observed, and the animals maintained the expected weight gain and feed intake. The RDT trials did not show mortality or signs of toxicity, as well as no change in body weight and organs, in the hematological and biochemical parameters, and also in relation to morphology and histology. Since the fermented milk did not cause any toxic effect in the conditions evaluated, it can be said that its no-adverse effect level (NOAEL) was considered to be higher than 20 mL/kg/day. Thus, the fermented milk with L. mucosae CNPC007 ... Mostrar Tudo |
Palavras-Chave: |
Alimento funcional; Autochthonous; Autochthonous lactic acid bacteria; Bactéria lática; Coculture techniques; Cultured milk products; In vivo assay; No-adverse efect level; Prebiótico. |
Thesagro: |
Fermentação Lática; Leite de Cabra; Leite Fermentado; Tecnologia de Alimento. |
Thesaurus Nal: |
Dairy products; Females; Fermented milk; Food safety; Food technology; Goat milk; Goats; Inulin; Lactic acid bacteria; Lactic fermentation; Mice; Prebiotics; Rats; Streptococcus thermophilus. |
Categoria do assunto: |
Q Alimentos e Nutrição Humana |
Marc: |
LEADER 03475naa a2200589 a 4500 001 2159590 005 2023-12-13 008 2023 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1007/s12602-021-09898-x$2DOI 100 1 $aPEREIRA, A. M. de S. 245 $aSafety evaluation of goat milk added with the prebiotic inulin fermented with the potentially probiotic native culture Limosilactobacillus mucosae CNPC007 in co-culture with Streptococcus thermophilus QGE$banalysis of acute and repeated dose oral toxicity.$h[electronic resource] 260 $c2023 520 $aAbstract: Despite functional goat milk products having emerged due to their importance for human nutrition and health, few studies have assessed the safety of consumption of goat dairy products containing potentially probiotic autochthonous lactic acid bacteria supplemented with prebiotic carbohydrates. Aiming this field, this study evaluated the safety of goat’s milk fermented with Streptococcus thermophilus QGE, the autochthonous Limosilactobacillus mucosae CNPC007 culture, and the prebiotic inulin, through single- and repeated-dose oral toxicity tests (SDT and RDT, respectively) in animals. Ten female Swiss Webster mice were used for SDT evaluation — 2 groups, SDTc (20 mL/kg of filtered water) and SDTt (20 mL/kg of fermented milk) — and 40 Wistar rats for RDT — RDT3, RDT6, and RDT12 (treated with fermented milk at doses of 3 mL/kg, 6 mL/kg, and 12 mL/kg, respectively) and also RDTc (12 mL/kg of filtered water). For SDT, no signs of mortality or toxicity were observed, and the animals maintained the expected weight gain and feed intake. The RDT trials did not show mortality or signs of toxicity, as well as no change in body weight and organs, in the hematological and biochemical parameters, and also in relation to morphology and histology. Since the fermented milk did not cause any toxic effect in the conditions evaluated, it can be said that its no-adverse effect level (NOAEL) was considered to be higher than 20 mL/kg/day. Thus, the fermented milk with L. mucosae CNPC007 and inulin was considered to be of low toxicity, safe for use in rodents, and allowed for use in further studies. 650 $aDairy products 650 $aFemales 650 $aFermented milk 650 $aFood safety 650 $aFood technology 650 $aGoat milk 650 $aGoats 650 $aInulin 650 $aLactic acid bacteria 650 $aLactic fermentation 650 $aMice 650 $aPrebiotics 650 $aRats 650 $aStreptococcus thermophilus 650 $aFermentação Lática 650 $aLeite de Cabra 650 $aLeite Fermentado 650 $aTecnologia de Alimento 653 $aAlimento funcional 653 $aAutochthonous 653 $aAutochthonous lactic acid bacteria 653 $aBactéria lática 653 $aCoculture techniques 653 $aCultured milk products 653 $aIn vivo assay 653 $aNo-adverse efect level 653 $aPrebiótico 700 1 $aLIMA, L. C. de A. S. 700 1 $aLIMA, L. W. S. 700 1 $aMENEZES, T. M. 700 1 $aVIEIRA, A. M. 700 1 $aFRANCO, E. de S. 700 1 $aPAZ, S. T. 700 1 $aMAIA, C. S. 700 1 $aEGITO, A. S. do 700 1 $aSANTOS, K. M. O. dos 700 1 $aBURITI, F. C. A. 700 1 $aMAIA, M. B. de S. 773 $tProbiotics Antimicrob Proteins$gv. 15, n. 3, p. 716-727, 2023.
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Embrapa Caprinos e Ovinos (CNPC) |
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| Acesso ao texto completo restrito à biblioteca da Embrapa Semiárido. Para informações adicionais entre em contato com cpatsa.biblioteca@embrapa.br. |
Registro Completo
Biblioteca(s): |
Embrapa Semiárido. |
Data corrente: |
30/11/2021 |
Data da última atualização: |
30/11/2021 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 1 |
Autoria: |
COLHO, E. M.; HAAS, I. C. da S.; AZEVEDO, L. C. de; BASTOS, D. C.; FEDRIGO, I. M. T.; LIMA, M. dos S; AMBONI, R. D. de M. C. |
Afiliação: |
EMANUELA MONTEIRO COELHO; ISABEL CRISTINA DA SILVA HAAS; LUCIANA CAVALCANTI DE AZEVEDO; DEBORA COSTA BASTOS, CPATSA; ISABELA MAIA TOALDO FEDRIGO; MARCOS DOS SANTOS LIMA; RENATA DIAS DE MELLO CASTANHO AMBONI. |
Título: |
Multivariate chemometric analysis for the evaluation of 22 citrus fruits growing in Brazil's semi-arid region. |
Ano de publicação: |
2021 |
Fonte/Imprenta: |
Journal of Food Composition and Analysis, v. 101, 103964, 2021. |
DOI: |
https://doi.org/10.1016/j.jfca.2021.103964 |
Idioma: |
Inglês |
Conteúdo: |
This work provides the first screening of 22 Citrus cultivars grown in a semi-arid tropical region based on their most relevant phytochemical and polyphenolic features through a multivariate approach. Multivariate chemometric analysis through PCA analysis were used combined to reach grouping of the Citrus fruits and unveil the main characteristics associated with the fruits identity and origin region. Citric acid was the dominant organic acid (4.43?140.54 g L? 1 ), representing 93.9 % of total organic acids quantified in the samples. Glucose and fructose corresponded, respectively, to 51.2 and 48.8 % of the total sugars quantified in samples. Hesperidin was the predominant flavonoid identified in all Citrus, particularly in oranges, while in pomelos, naringin was the major polyphenol. The results showed that most phenolics are related to Citrus identity, as PCA revealed the grouping of samples according to the species or variety. The associations found for the Citrus obtained from the same semi-arid tropical location could be used as basis for authentication of these Citrus samples, as judged by the distinctions found between the phenolic profiles, sugars and organic acids. This could be used for other fruits upon verification of their polyphenolic association with location and climate. |
Palavras-Chave: |
Semiarido; Variedades cítricas. |
Thesagro: |
Citricultura; Clima Tropical; Composição Química; Composto Fenólico. |
Thesaurus NAL: |
Chemical composition; Citrus; Phenolic compounds. |
Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
Marc: |
LEADER 02283naa a2200313 a 4500 001 2136801 005 2021-11-30 008 2021 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1016/j.jfca.2021.103964$2DOI 100 1 $aCOLHO, E. M. 245 $aMultivariate chemometric analysis for the evaluation of 22 citrus fruits growing in Brazil's semi-arid region.$h[electronic resource] 260 $c2021 520 $aThis work provides the first screening of 22 Citrus cultivars grown in a semi-arid tropical region based on their most relevant phytochemical and polyphenolic features through a multivariate approach. Multivariate chemometric analysis through PCA analysis were used combined to reach grouping of the Citrus fruits and unveil the main characteristics associated with the fruits identity and origin region. Citric acid was the dominant organic acid (4.43?140.54 g L? 1 ), representing 93.9 % of total organic acids quantified in the samples. Glucose and fructose corresponded, respectively, to 51.2 and 48.8 % of the total sugars quantified in samples. Hesperidin was the predominant flavonoid identified in all Citrus, particularly in oranges, while in pomelos, naringin was the major polyphenol. The results showed that most phenolics are related to Citrus identity, as PCA revealed the grouping of samples according to the species or variety. The associations found for the Citrus obtained from the same semi-arid tropical location could be used as basis for authentication of these Citrus samples, as judged by the distinctions found between the phenolic profiles, sugars and organic acids. This could be used for other fruits upon verification of their polyphenolic association with location and climate. 650 $aChemical composition 650 $aCitrus 650 $aPhenolic compounds 650 $aCitricultura 650 $aClima Tropical 650 $aComposição Química 650 $aComposto Fenólico 653 $aSemiarido 653 $aVariedades cítricas 700 1 $aHAAS, I. C. da S. 700 1 $aAZEVEDO, L. C. de 700 1 $aBASTOS, D. C. 700 1 $aFEDRIGO, I. M. T. 700 1 $aLIMA, M. dos S 700 1 $aAMBONI, R. D. de M. C. 773 $tJournal of Food Composition and Analysis$gv. 101, 103964, 2021.
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