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 | Acesso ao texto completo restrito à biblioteca da Embrapa Alimentos e Territórios. Para informações adicionais entre em contato com mara.petrocchi@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Alimentos e Territórios. |
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Data corrente: |
18/07/2023 |
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Data da última atualização: |
16/11/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
BEZERRA, J. N.; GOMEZ, M. C. V.; ROLÓN, M.; CORONEL, C.; ALMEIDA-BEZERRA, J. W.; FIDELIS, K. R.; MENEZES, S. A. de; CRUZ, R. P. da; DUARTE, A. E.; RIBEIRO, P. R. V.; BRITO, E. S. de; COUTINHO, H. D. M.; MORAIS-BRAGA, M. F. B.; BEZERRA, C. F. |
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Afiliação: |
JÉSSICA NOGUEIRA BEZERRA, URCA; MARIA CELESTE VEGA GOMEZ, FUNDACIÓN MOISÉS BERTONI; MÍRIAN ROLÓN, FUNDACIÓN MOISÉS BERTONI; CATHIA CORONEL, FUNDACIÓN MOISÉS BERTONI; JOSÉ WEVERTON ALMEIDA-BEZERRA, UFPE; KLEBER RIBEIRO FIDELIS, UFPE; SAULO ALMEIDA DE MENEZES, UFPE; RAFAEL PEREIRA DA CRUZ, URCA; ANTÔNIA ELIENE DUARTE, URCA; PAULO RICELI VASCONCELOS RIBEIRO, CNAT; EDY SOUSA DE BRITO, CNAT; HENRIQUE DOUGLAS MELO COUTINHO, URCA; MARIA FLAVIANA BEZERRA MORAIS-BRAGA, URCA; CAMILA FONSECA BEZERRA, URCA. |
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Título: |
Chemical composition, Evaluation of Antiparasitary and Cytotoxic Activity of the essential oil of Psidium brownianum MART EX. DC. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Biocatalysis and Agricultural Biotechnology, v. 39, 102247, 2022. |
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ISSN: |
1878-8181 |
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DOI: |
https://doi.org/10.1016/j.bcab.2021.102247 |
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Idioma: |
Inglês |
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Conteúdo: |
Chagas Disease and Leishmaniasis are neglected parasitic diseases that constitute a major public health problem. In the search for new therapeutic alternatives for such pathologies, the essential oil of the leaves of Psidium brownianum Mart ex DC was investigated egarding its chemical composition, antiparasitic, and cytotoxic effects. The chemical composition of the oil was analyzed by gas chromatography coupled to mass spectrometry (GC/MS), showing two major constituents: Isogermafurene (52.93%) and Germacrone (16.02%). In antiparasitic activity, the oil was tested against the epimastigote forms of Trypanosoma cruzi, revealing 57.05% inhibition at the highest tested concentration (1000 μg/mL). In regard to antiparasitic activity against promastigote forms of Leishmania braziliensis and ishmania infantum, it obtained 92.61% and 84.16% inhibition, respectively, at the highest concentrations (1000 μg/mL). As for the cytotoxic effects, it showed high cytotoxicity, with IC50 = 328.9 μg/mL. The inhibitory concentration (IC50) obtained the best result for the promastigote forms of L. braziliensis (IC50 = 37.53 μg/mL), as well as the selectivity index (SI = 8.76). Such results generate perspectives for new research and may contribute to more effective drug discoveries. |
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Palavras-Chave: |
Anti kinetoplastid; Antiparasitic; Citotóxicos; Doenças parasitárias; Efeito antiparasitário; Parasitic disease; Pathologies; Phytochemistry; Psidium brownianum Mart ex DC; Terapêutica alternativa; Therapeutic alternatives. |
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Thesagro: |
Doença de Chagas; Leishmaniose; Myrtaceae; Óleo Vegetal; Saúde Pública. |
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Thesaurus Nal: |
Chagas disease; Cytotoxicity; Public health; Vegetable oil. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
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022 $a1878-8181
024 7 $ahttps://doi.org/10.1016/j.bcab.2021.102247$2DOI
100 1 $aBEZERRA, J. N.
245 $aChemical composition, Evaluation of Antiparasitary and Cytotoxic Activity of the essential oil of Psidium brownianum MART EX. DC.$h[electronic resource]
260 $c2022
520 $aChagas Disease and Leishmaniasis are neglected parasitic diseases that constitute a major public health problem. In the search for new therapeutic alternatives for such pathologies, the essential oil of the leaves of Psidium brownianum Mart ex DC was investigated egarding its chemical composition, antiparasitic, and cytotoxic effects. The chemical composition of the oil was analyzed by gas chromatography coupled to mass spectrometry (GC/MS), showing two major constituents: Isogermafurene (52.93%) and Germacrone (16.02%). In antiparasitic activity, the oil was tested against the epimastigote forms of Trypanosoma cruzi, revealing 57.05% inhibition at the highest tested concentration (1000 μg/mL). In regard to antiparasitic activity against promastigote forms of Leishmania braziliensis and ishmania infantum, it obtained 92.61% and 84.16% inhibition, respectively, at the highest concentrations (1000 μg/mL). As for the cytotoxic effects, it showed high cytotoxicity, with IC50 = 328.9 μg/mL. The inhibitory concentration (IC50) obtained the best result for the promastigote forms of L. braziliensis (IC50 = 37.53 μg/mL), as well as the selectivity index (SI = 8.76). Such results generate perspectives for new research and may contribute to more effective drug discoveries.
650 $aChagas disease
650 $aCytotoxicity
650 $aPublic health
650 $aVegetable oil
650 $aDoença de Chagas
650 $aLeishmaniose
650 $aMyrtaceae
650 $aÓleo Vegetal
650 $aSaúde Pública
653 $aAnti kinetoplastid
653 $aAntiparasitic
653 $aCitotóxicos
653 $aDoenças parasitárias
653 $aEfeito antiparasitário
653 $aParasitic disease
653 $aPathologies
653 $aPhytochemistry
653 $aPsidium brownianum Mart ex DC
653 $aTerapêutica alternativa
653 $aTherapeutic alternatives
700 1 $aGOMEZ, M. C. V.
700 1 $aROLÓN, M.
700 1 $aCORONEL, C.
700 1 $aALMEIDA-BEZERRA, J. W.
700 1 $aFIDELIS, K. R.
700 1 $aMENEZES, S. A. de
700 1 $aCRUZ, R. P. da
700 1 $aDUARTE, A. E.
700 1 $aRIBEIRO, P. R. V.
700 1 $aBRITO, E. S. de
700 1 $aCOUTINHO, H. D. M.
700 1 $aMORAIS-BRAGA, M. F. B.
700 1 $aBEZERRA, C. F.
773 $tBiocatalysis and Agricultural Biotechnology$gv. 39, 102247, 2022.
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Embrapa Alimentos e Territórios (CNAT) |
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| Registros recuperados : 481 | |
| 1. |  | MACEDO, J. The Brazilian cerrados. In: INTERNATIONAL WORKSHOP ON SOIL, WATER, AND NUTRIENT MANAGEMENT RESEARCH: environmental and productivity dimensions, 1994, Zschortau, Germany. Proceedings: the Zschortau plan for the implementation of soil, water, and nutrient ... . Zchortau: DSE/Bangkok: IBSRAM, 1995. p.78-86.| Biblioteca(s): Embrapa Cerrados. |
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| 3. | | MACEDO, J. Os solos da regiao dos cerrados. In: ALVAREZ V., V.H.; FONTES, L.E.F.; FONTES, M.P.F. (Ed.). O solo nos grandes dominios morfoclimaticos do Brasil e o desenvolvimento sustentado. Vicosa: SBCS/UFV, 1996. p.135-155.| Biblioteca(s): Embrapa Cerrados. |
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| 6. | | MACEDO, J. Produção de alimentos: o potencial dos cerrados. Planaltina, DF: EMBRAPA-CPAC, 1996. 33 p. (EMBRAPA-CPAC. Documentos, 59). Apresentado no "Workshop de Ecologia e Biodiversidade", com o titulo "Prospectives for the rational use of the Brazilian's Cerrados for food production", Rio de Janeiro, 1994 (CRI4028). Ver CRI3752.| Biblioteca(s): Embrapa Cerrados. |
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| 9. | | MACEDO, J. R. de. Erosão em pastagens. Portal Dia de Campo, 18 ago. 2010. Disponível em : < http://www.diadecampo.com.br>. Acesso em: 09 fev. 2011.| Tipo: Artigo de Divulgação na Mídia |
| Biblioteca(s): Embrapa Solos. |
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| 18. | | MACEDO, J. L. V. de. Atividades de manejo na área experimental. In: SHIFT PROJECT ENV 23 (Manaus-AM). Recuperação de áreas degradadas e abandonadas, através de sistemas de policultivo. Manaus: EMBRAPA-CPAA: University of Hamburg, 1998. p. 1-2.| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Amazônia Ocidental. |
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| 19. | | MACEDO, J. L. V. de. Cultivo de fruteiras em sistemas agroflorestais. In: ENCONTRO DE FRUTAS NATIVAS DO NORTE E NORDESTE DO BRASIL, 1., 2008, São Luís. Frutas nativas: novos sabores para o mundo. São Luís: UEMA: SBF: EMBRAPA: SEBRAE: SEAGRO, 2008. 1 CD-ROM.| Tipo: Artigo em Anais de Congresso / Nota Técnica |
| Biblioteca(s): Embrapa Amazônia Ocidental. |
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| Registros recuperados : 481 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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