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 | Acesso ao texto completo restrito à biblioteca da Embrapa Pecuária Sudeste. Para informações adicionais entre em contato com cppse.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
08/03/2023 |
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Data da última atualização: |
08/03/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
BUSS, C. E.; AFONSO, J.; OLIVEIRA, P. S. N. DE; PETRINI, J.; TIZIOTO, P. C.; CESAR, A. S. M.; GUSTANI-BUSS, E. C.; CARDOSO, T. F.; ROVADOSKI, G. A.; DINIZ, W. J. DA S.; LIMA, A. O. DE; ROCHA, M. I. P.; ANDRADE, B. G. N.; WOLF, J. B.; COUTINHO, L. L.; MOURÃO, G. B.; REGITANO, L. C. de A. |
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Afiliação: |
CARLOS EDUARDO BUSS, Federal University of São Carlos; JULIANA AFONSO; PRISCILA S. N. DE OLIVEIRA, Federal University of São Carlos; JULIANA PETRINI, University of São Paulo/ESALQ, Piracicaba; POLYANA CRISTINE TIZIOTO, NGS Soluções Genômicas; ALINE S. M. CESAR, University of São Paulo/ESALQ; EMANUELE CRISTINA GUSTANI-BUSS, Mindflow Genomics, Leuven, Flanders, Belgium.; TAINÃ FIGUEIREDO CARDOSO; GREGORI A. ROVADOSKI, University of São Paulo/ESALQ; WELLISON JARLES DA SILVA DINIZ, Auburn University; ANDRESSA OLIVEIRA DE LIMA, University of Washington; MARINA IBELLI PEREIRA ROCHA, Federal University of São Carlos; BRUNO GABRIEL NASCIMENTO ANDRADE, Munster Technological University/MTU; JASON B. WOLF, University of Bath; LUIZ LEHMANN COUTINHO, University of São Paulo/ESALQ; GERSON BARRETO MOURÃO, University of São Paulo/ESALQ; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
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Título: |
Bivariate GWAS reveals pleiotropic regions among feed efficiency and beef quality-related traits in Nelore cattle. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Mammalian Genome, v. 34, p. 90-103, dec. 2022. |
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DOI: |
10.1007/s00335-022-09969-6 |
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Idioma: |
Inglês |
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Conteúdo: |
Feed-efcient cattle selection is among the most leading solutions to reduce cost for beef cattle production. However, technical difculties in measuring feed efciency traits had limited the application in livestock. Here, we performed a Bivariate Genome-Wide Association Study (Bi-GWAS) and presented candidate biological mechanisms underlying the association between feed efciency and meat quality traits in a half-sibling design with 353 Nelore steers derived from 34 unrelated sires. A total of 13 Quantitative Trait Loci (QTL) were found explaining part of the phenotypic variations. An important transcription factor of adipogenesis in cattle, the TAL1 (rs133408775) gene located on BTA3 was associated with intramuscular fat and average daily gain (IMF-ADG), and a region located on BTA20, close to CD180 and MAST4 genes, both related to fat accumulation. We observed a low positive genetic correlation between IMF-ADG (r=0.30±0.0686), indicating that it may respond to selection in the same direction. Our fndings contributed to clarifying the pleiotropic modulation of the complex traits, indicating new QTLs for bovine genetic improvement. |
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Palavras-Chave: |
Bi GWAS; Efciency and meat quality; Phenotypic variations; Pleiotropic modulation; QTL. |
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Categoria do assunto: |
G Melhoramento Genético |
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Marc: |
LEADER 02281naa a2200385 a 4500
001 2152195
005 2023-03-08
008 2022 bl uuuu u00u1 u #d
024 7 $a10.1007/s00335-022-09969-6$2DOI
100 1 $aBUSS, C. E.
245 $aBivariate GWAS reveals pleiotropic regions among feed efficiency and beef quality-related traits in Nelore cattle.$h[electronic resource]
260 $c2022
520 $aFeed-efcient cattle selection is among the most leading solutions to reduce cost for beef cattle production. However, technical difculties in measuring feed efciency traits had limited the application in livestock. Here, we performed a Bivariate Genome-Wide Association Study (Bi-GWAS) and presented candidate biological mechanisms underlying the association between feed efciency and meat quality traits in a half-sibling design with 353 Nelore steers derived from 34 unrelated sires. A total of 13 Quantitative Trait Loci (QTL) were found explaining part of the phenotypic variations. An important transcription factor of adipogenesis in cattle, the TAL1 (rs133408775) gene located on BTA3 was associated with intramuscular fat and average daily gain (IMF-ADG), and a region located on BTA20, close to CD180 and MAST4 genes, both related to fat accumulation. We observed a low positive genetic correlation between IMF-ADG (r=0.30±0.0686), indicating that it may respond to selection in the same direction. Our fndings contributed to clarifying the pleiotropic modulation of the complex traits, indicating new QTLs for bovine genetic improvement.
653 $aBi GWAS
653 $aEfciency and meat quality
653 $aPhenotypic variations
653 $aPleiotropic modulation
653 $aQTL
700 1 $aAFONSO, J.
700 1 $aOLIVEIRA, P. S. N. DE
700 1 $aPETRINI, J.
700 1 $aTIZIOTO, P. C.
700 1 $aCESAR, A. S. M.
700 1 $aGUSTANI-BUSS, E. C.
700 1 $aCARDOSO, T. F.
700 1 $aROVADOSKI, G. A.
700 1 $aDINIZ, W. J. DA S.
700 1 $aLIMA, A. O. DE
700 1 $aROCHA, M. I. P.
700 1 $aANDRADE, B. G. N.
700 1 $aWOLF, J. B.
700 1 $aCOUTINHO, L. L.
700 1 $aMOURÃO, G. B.
700 1 $aREGITANO, L. C. de A.
773 $tMammalian Genome$gv. 34, p. 90-103, dec. 2022.
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