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Registro Completo |
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Biblioteca(s): |
Embrapa Clima Temperado. |
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Data corrente: |
14/06/2022 |
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Data da última atualização: |
14/06/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SPOHR, L.; SOARES, M. S. P.; BONA, N. P.; PEDRA, N. S.; BARSCHAK, A. G.; ALVARIZ, R. M.; VIZZOTTO, M.; LENCINA, C. L.; STEFANELLO, F. M.; SPANEVELLO, R. M. |
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Afiliação: |
LUIZA SPOHR, UFPEL; MAYARA SANDRIELLY PEREIRA SOARES, UFPEL; NATÁLIA PONTES BONA, UFPEL; NATHALIA STARK PEDRA, UFPEL; ALETHÉA GATTO BARSCHAK, Universidade Federal de Ciências da Saúde de Porto Alegre; RAFAELA MARTINS ALVARIZ, Universidade Federal de Ciências da Saúde de Porto Alegre; MARCIA VIZZOTTO FOSTER, CPACT; CLAITON LEONETI LENCINA, UFPEL; FRANCIELI MORO STEFANELLO, UFPEL; ROSELIA MARIA SPANEVELLO, UFPEL. |
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Título: |
Effect of blueberry extract on energetic metabolism, levels of brain-derived neurotrophic factor, and Ca2+-ATPase activity in the hippocampus and cerebral cortex of rats submitted to ketamine-induced mania-like behavior. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Metabolic Brain Disease, v. 37, n. 3, p. 835-847, Mar. 2022. |
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ISSN: |
1573-7365 |
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DOI: |
https://doi.org/10.1007/s11011-022-00904-x |
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Idioma: |
Inglês |
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Conteúdo: |
Bipolar disorder (BD) is a psychiatric disease characterized by mood episodes. Blueberry is rich in bioactive compounds and shows excellent therapeutic potential against chronic diseases. The aim of this study was to evaluate the e?ects of blueberry extract on behavior, energetic metabolism, Ca2+-ATPase activity, and levels of brain-derived neurotrophic factor (BDNF) in the cerebral cortex and hippocampus of rats submitted to an animal model of mania induced by ketamine. Vehicle, lithium (45 mg/kg, twice a day), or blueberry extract (200 mg/kg), was orally administered to Wistar rats for 14 days. Ketamine (25 mg/kg) or vehicle was administered intraperitoneally, once a day, between the 8th and 14th day. On the 15th day, animals received ketamine or vehicle and were subjected to the open ?eld test. Our results demonstrated that the administration of lithium and blueberry extract prevented ketamine-induced hyperlocomotion (P < 0.01). Blueberry extract attenuated the ketamine-induced reduction in the activity of complex I in the cerebral cortex (P < 0.05). Additionally, the administration of ketamine reduced the activities of complexes I and IV (P < 0.05) and citrate synthase in the hippocampus (P < 0.01). However, blueberry extract attenuated the inhibition in the activity of complex IV (P < 0.01). Furthermore, ketamine reduced the Ca2+-ATPase activity in the cerebral cortex and hippocampus (P < 0.05); however, blueberry extract prevented the change in the cerebral cortex (P < 0.05). There were no signi?cant alterations in the levels of BDNF (P > 0.05). In conclusion, this suggested that the blueberry extract can serve as a potential therapeutic strategy for studies searching for novel therapeutic alternatives for BD patients. MenosBipolar disorder (BD) is a psychiatric disease characterized by mood episodes. Blueberry is rich in bioactive compounds and shows excellent therapeutic potential against chronic diseases. The aim of this study was to evaluate the e?ects of blueberry extract on behavior, energetic metabolism, Ca2+-ATPase activity, and levels of brain-derived neurotrophic factor (BDNF) in the cerebral cortex and hippocampus of rats submitted to an animal model of mania induced by ketamine. Vehicle, lithium (45 mg/kg, twice a day), or blueberry extract (200 mg/kg), was orally administered to Wistar rats for 14 days. Ketamine (25 mg/kg) or vehicle was administered intraperitoneally, once a day, between the 8th and 14th day. On the 15th day, animals received ketamine or vehicle and were subjected to the open ?eld test. Our results demonstrated that the administration of lithium and blueberry extract prevented ketamine-induced hyperlocomotion (P < 0.01). Blueberry extract attenuated the ketamine-induced reduction in the activity of complex I in the cerebral cortex (P < 0.05). Additionally, the administration of ketamine reduced the activities of complexes I and IV (P < 0.05) and citrate synthase in the hippocampus (P < 0.01). However, blueberry extract attenuated the inhibition in the activity of complex IV (P < 0.01). Furthermore, ketamine reduced the Ca2+-ATPase activity in the cerebral cortex and hippocampus (P < 0.05); however, blueberry extract prevented the change in the cerebral cortex (P <... Mostrar Tudo |
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Palavras-Chave: |
Composto bioativo; Transtorno bipolar. |
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Thesagro: |
Antocianina; Mirtilo; Mitocôndria; Saúde; Terapia. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02861naa a2200337 a 4500
001 2144069
005 2022-06-14
008 2022 bl uuuu u00u1 u #d
022 $a1573-7365
024 7 $ahttps://doi.org/10.1007/s11011-022-00904-x$2DOI
100 1 $aSPOHR, L.
245 $aEffect of blueberry extract on energetic metabolism, levels of brain-derived neurotrophic factor, and Ca2+-ATPase activity in the hippocampus and cerebral cortex of rats submitted to ketamine-induced mania-like behavior.$h[electronic resource]
260 $c2022
520 $aBipolar disorder (BD) is a psychiatric disease characterized by mood episodes. Blueberry is rich in bioactive compounds and shows excellent therapeutic potential against chronic diseases. The aim of this study was to evaluate the e?ects of blueberry extract on behavior, energetic metabolism, Ca2+-ATPase activity, and levels of brain-derived neurotrophic factor (BDNF) in the cerebral cortex and hippocampus of rats submitted to an animal model of mania induced by ketamine. Vehicle, lithium (45 mg/kg, twice a day), or blueberry extract (200 mg/kg), was orally administered to Wistar rats for 14 days. Ketamine (25 mg/kg) or vehicle was administered intraperitoneally, once a day, between the 8th and 14th day. On the 15th day, animals received ketamine or vehicle and were subjected to the open ?eld test. Our results demonstrated that the administration of lithium and blueberry extract prevented ketamine-induced hyperlocomotion (P < 0.01). Blueberry extract attenuated the ketamine-induced reduction in the activity of complex I in the cerebral cortex (P < 0.05). Additionally, the administration of ketamine reduced the activities of complexes I and IV (P < 0.05) and citrate synthase in the hippocampus (P < 0.01). However, blueberry extract attenuated the inhibition in the activity of complex IV (P < 0.01). Furthermore, ketamine reduced the Ca2+-ATPase activity in the cerebral cortex and hippocampus (P < 0.05); however, blueberry extract prevented the change in the cerebral cortex (P < 0.05). There were no signi?cant alterations in the levels of BDNF (P > 0.05). In conclusion, this suggested that the blueberry extract can serve as a potential therapeutic strategy for studies searching for novel therapeutic alternatives for BD patients.
650 $aAntocianina
650 $aMirtilo
650 $aMitocôndria
650 $aSaúde
650 $aTerapia
653 $aComposto bioativo
653 $aTranstorno bipolar
700 1 $aSOARES, M. S. P.
700 1 $aBONA, N. P.
700 1 $aPEDRA, N. S.
700 1 $aBARSCHAK, A. G.
700 1 $aALVARIZ, R. M.
700 1 $aVIZZOTTO, M.
700 1 $aLENCINA, C. L.
700 1 $aSTEFANELLO, F. M.
700 1 $aSPANEVELLO, R. M.
773 $tMetabolic Brain Disease$gv. 37, n. 3, p. 835-847, Mar. 2022.
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| 6. |  | RODRIGUES, L. O.; VILELA, L.; AYARZA, M. A.; KITAYAMA, K. Avaliação da fauna do solo sob vários sistemas de manejo em um latossolo da região dos cerrados. In: SIMPOSIO SOBRE O CERRADO, 8.; INTERNATIONAL SYMPOSIUM ON TROPICAL SAVANNAS, 1., 1996, Brasilia, DF. Biodiversidade e producao sustentavel de alimentos e fibras nos Cerrados: anais... Planaltina: EMBRAPA-CPAC, 1996. p.375-378.| Biblioteca(s): Embrapa Cerrados. |
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| 7. | | VILELA, L.; AYARZA, M. A.; MIRANDA, J. C. C. de. Agropastoral systems: activities developed by Cerrados Agricultural Research Center (Embrapa Cerrados). In: KANNO, T.; MACEDO, M.C.M., ed. JIRCAS / EMBRAPA gado de corte international joint workshop on agropastoral system in South America. [Tsukuba]: JIRCAS, 2001. p.19-33. (JIRCAS Working Report, 19). EMBRAPA-CNPGC and JIRCAS joint International Workshop on Agrospatoral System in South America, held in Campo Grande, MS, Brazil, 1999.| Biblioteca(s): Embrapa Cerrados. |
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| 16. | | AYARZA, M. A.; VILELA, L.; PIZARRO, E. A.; COSTA, P. H. da. Sistemas agropastoriles basados en leguminosas de usos multiples. In: GUIMARAES, E.P.; SANZ, J.I.; RAO, I.M.; AMEZQUITA, M.C.; AMEZQUITA, E., ed. Sistemas agropastoriles en sabanas tropicales de America Latina. Cali: CIAT/Brasilia: Embrapa, 1999. p.175-193.| Biblioteca(s): Embrapa Cerrados. |
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| 18. | | FUHRMANN, S.; NEUFELDT, H.; WESTERHOF, R.; AYARZA, M. A.; SILVA, J. E. da; ZECH, W. Soil organic carbon, carbohydrates, amino sugars, and potentially mineralizable nitrogen under different land-use systems in oxisols of the Brazilian cerrados. In: THOMAS, R.; AYARZA, M.A., ed. Sustainable land management for the oxisols of the Latin American savannas: dynamics of soil organic matter and indicators of soil quality. Cali: CIAT, 1999. p.110-122.| Biblioteca(s): Embrapa Cerrados. |
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| 20. | | LILIENFEIN, J.; WILCKE, W.; AYARZA, M. A.; VILELA, L.; LIMA, S. do C.; ZECK, W. Soil acidification in Pinus caribaea forests on Brazilian savanna oxisols. Forest Ecology and Management, Amsterdam, v. 128, p. 145-157, 2000.| Biblioteca(s): Embrapa Cerrados. |
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