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 | Acesso ao texto completo restrito à biblioteca da Embrapa Suínos e Aves. Para informações adicionais entre em contato com cnpsa.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Suínos e Aves. |
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Data corrente: |
02/08/2021 |
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Data da última atualização: |
02/08/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
MARCIANO, C. M. M.; IBELLI, A. M. G.; MARCHESI, J. A. P.; PEIXOTO, J. de O.; FERNANDES, L. T.; SAVOLDI, I. R.; CARMO, K. B. do; LEDUR, M. C. |
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Afiliação: |
CAROLINE MICHELE MARINHO MARCIANO, UDESC/Chapecó; ADRIANA MERCIA GUARATINI IBELLI, CNPSA; JORGE AUGUSTO PETROLI MARCHESI, USP; JANE DE OLIVEIRA PEIXOTO, CNPSA; LANA TEIXEIRA FERNANDES; IGOR RICARDO SAVOLDI, UDESC/Chapecó; KAMILLA BLEIL DO CARMO, UNC/Concórdia; MONICA CORREA LEDUR, CNPSA. |
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Título: |
Differential expression of myogenic and calcium signaling-related genes in broilers affected with white striping. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Frontiers in Physiology, v. 12, n. 712464, 2021. |
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DOI: |
10.3389/fphys.2021.712464 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: White Striping (WS) has been one of the main issues in poultry production in the last years since it affects meat quality. Studies have been conducted to understand WS and other myopathies in chickens, and some biological pathways have been associated to the prevalence of these conditions, such as extracellular calcium level, oxidative stress, localized hypoxia, possible fiber-type switching, and cellular repairing. Therefore, to understand the genetic mechanisms involved in WS, 15 functional candidate genes were chosen to be analyzed by quantitative PCR (qPCR) in breast muscle of normal and WS-affected chickens. To this, the pectoral major muscle (PMM) of 16 normal and 16 WS-affected broilers were collected at 42 days of age and submitted to qRT-PCR analysis. Out of the 15 genes studied, six were differentially expressed between groups. The CA2, CSRP3, and PLIN1 were upregulated, while CALM2, DNASE1L3, and MYLK2 genes were downregulated in the WS-affected when compared to the normal broilers. These findings highlight that the disruption on muscle and calcium signaling pathways can possibly be triggering WS in chickens. Improving our understanding on the genetic basis involved with this myopathy might contribute for reducing WS in poultry production. |
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Palavras-Chave: |
Glycogen metabolism; Pectoral myopathy; Quantitative PCR. |
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Thesagro: |
Frango; Galinha; Melhoramento Genético Animal. |
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Thesaurus Nal: |
Animal genetics; Broiler chickens; Gene expression. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02260naa a2200325 a 4500
001 2133180
005 2021-08-02
008 2021 bl uuuu u00u1 u #d
024 7 $a10.3389/fphys.2021.712464$2DOI
100 1 $aMARCIANO, C. M. M.
245 $aDifferential expression of myogenic and calcium signaling-related genes in broilers affected with white striping.$h[electronic resource]
260 $c2021
520 $aAbstract: White Striping (WS) has been one of the main issues in poultry production in the last years since it affects meat quality. Studies have been conducted to understand WS and other myopathies in chickens, and some biological pathways have been associated to the prevalence of these conditions, such as extracellular calcium level, oxidative stress, localized hypoxia, possible fiber-type switching, and cellular repairing. Therefore, to understand the genetic mechanisms involved in WS, 15 functional candidate genes were chosen to be analyzed by quantitative PCR (qPCR) in breast muscle of normal and WS-affected chickens. To this, the pectoral major muscle (PMM) of 16 normal and 16 WS-affected broilers were collected at 42 days of age and submitted to qRT-PCR analysis. Out of the 15 genes studied, six were differentially expressed between groups. The CA2, CSRP3, and PLIN1 were upregulated, while CALM2, DNASE1L3, and MYLK2 genes were downregulated in the WS-affected when compared to the normal broilers. These findings highlight that the disruption on muscle and calcium signaling pathways can possibly be triggering WS in chickens. Improving our understanding on the genetic basis involved with this myopathy might contribute for reducing WS in poultry production.
650 $aAnimal genetics
650 $aBroiler chickens
650 $aGene expression
650 $aFrango
650 $aGalinha
650 $aMelhoramento Genético Animal
653 $aGlycogen metabolism
653 $aPectoral myopathy
653 $aQuantitative PCR
700 1 $aIBELLI, A. M. G.
700 1 $aMARCHESI, J. A. P.
700 1 $aPEIXOTO, J. de O.
700 1 $aFERNANDES, L. T.
700 1 $aSAVOLDI, I. R.
700 1 $aCARMO, K. B. do
700 1 $aLEDUR, M. C.
773 $tFrontiers in Physiology$gv. 12, n. 712464, 2021.
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