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 | Acesso ao texto completo restrito à biblioteca da Embrapa Pecuária Sudeste. Para informações adicionais entre em contato com cppse.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
26/04/2021 |
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Data da última atualização: |
26/04/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
POLITI, F. A. S.; BUENO, R. V.; ZEOLY, L. A.; FANTATTO, R. R.; ELOY, J. DE O.; CHORILLI, M.; COELHO, F.; GUIDO, R. V. C.; CHAGAS, A. C. de S.; FURLAN, M. |
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Afiliação: |
FLÁVIO AUGUSTO SANCHES POLITI, UNESP; RENATA VIEIRA BUENO, USP; LUCAS ANDRÉ ZEOLY, UNICAMP; RAFAELA REGINA FANTATTO, UNESP; JOSIMAR DE OLIVEIRA ELOY, UFC; MARLUS CHORILLI, UNESP; FERNANDO COELHO, UNICAMP; RAFAEL VICTÓRIO CARVALHO GUIDO, USP; ANA CAROLINA DE SOUZA CHAGAS, CPPSE; MAYSA FURLAN, UNESP. |
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Título: |
Anthelmintic activity of a nanoformulation based on thiophenes identified in Tagetes patula L. (Asteraceae) against the small ruminant nematode Haemonchus contortus. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Acta Tropica, v.219, jul. 2021, 105920. |
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Páginas: |
10 p. |
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ISSN: |
0001-706X |
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DOI: |
https://doi.org/10.1016/j.actatropica.2021.105920 |
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Idioma: |
Inglês |
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Conteúdo: |
The synthesis of thiophenic compounds, previously identified in Tagetes patula, revealed that 4-(5?-(hydroxymethyl)-[2,2?-bithiophene]-5-yl)but-3-yn-1-ol), or simply Thio1, has a pronounced in vitro anthelmintic effect against Haemonchus contortus, showing 100% efficacy in the egg hatch and larval development tests presenting EC50 = 0.1731 mg.mL? 1 and EC50 = 0.3243 mg.mL? 1 , respectively. So, this compound was selected to preparation of a nanostructured formulation to be orally administered to Santa In?es sheep. In general, from the fecal egg count reduction test (FECRT), it was observed that the product kept the parasitic load in the digestive tract of the hosts stable, with eggs per gram of faeces (EPG) counts having a mean value < 3,000 (EPGmean = 2167.1, efficacy = 36,45%), thus protecting the animals from health risks caused by a massive nematode infestation. To better understand the mode of action of this thiophene derivative, in silico molecular modeling studies were carried out with the glutamate-activated chloride channel (GluCl), a well-known molecular target of anthelmintic compounds. Based on the affinity score (GlideScore = -5.7 kcal.mol? 1 ) and the proposed binding mode, Thio1 could be classified as a potential GluCl ligand, justifying the promising results observed in the anthelmintic assays. |
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Palavras-Chave: |
Docking; French marigold; In vitro; In vivo; UNC 49 receptor. |
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Thesaurus Nal: |
Gastrointestinal nematodes. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 02358naa a2200337 a 4500
001 2131499
005 2021-04-26
008 2021 bl uuuu u00u1 u #d
022 $a0001-706X
024 7 $ahttps://doi.org/10.1016/j.actatropica.2021.105920$2DOI
100 1 $aPOLITI, F. A. S.
245 $aAnthelmintic activity of a nanoformulation based on thiophenes identified in Tagetes patula L. (Asteraceae) against the small ruminant nematode Haemonchus contortus.$h[electronic resource]
260 $c2021
300 $a10 p.
520 $aThe synthesis of thiophenic compounds, previously identified in Tagetes patula, revealed that 4-(5?-(hydroxymethyl)-[2,2?-bithiophene]-5-yl)but-3-yn-1-ol), or simply Thio1, has a pronounced in vitro anthelmintic effect against Haemonchus contortus, showing 100% efficacy in the egg hatch and larval development tests presenting EC50 = 0.1731 mg.mL? 1 and EC50 = 0.3243 mg.mL? 1 , respectively. So, this compound was selected to preparation of a nanostructured formulation to be orally administered to Santa In?es sheep. In general, from the fecal egg count reduction test (FECRT), it was observed that the product kept the parasitic load in the digestive tract of the hosts stable, with eggs per gram of faeces (EPG) counts having a mean value < 3,000 (EPGmean = 2167.1, efficacy = 36,45%), thus protecting the animals from health risks caused by a massive nematode infestation. To better understand the mode of action of this thiophene derivative, in silico molecular modeling studies were carried out with the glutamate-activated chloride channel (GluCl), a well-known molecular target of anthelmintic compounds. Based on the affinity score (GlideScore = -5.7 kcal.mol? 1 ) and the proposed binding mode, Thio1 could be classified as a potential GluCl ligand, justifying the promising results observed in the anthelmintic assays.
650 $aGastrointestinal nematodes
653 $aDocking
653 $aFrench marigold
653 $aIn vitro
653 $aIn vivo
653 $aUNC 49 receptor
700 1 $aBUENO, R. V.
700 1 $aZEOLY, L. A.
700 1 $aFANTATTO, R. R.
700 1 $aELOY, J. DE O.
700 1 $aCHORILLI, M.
700 1 $aCOELHO, F.
700 1 $aGUIDO, R. V. C.
700 1 $aCHAGAS, A. C. de S.
700 1 $aFURLAN, M.
773 $tActa Tropica$gv.219, jul. 2021, 105920.
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