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 | Acesso ao texto completo restrito à biblioteca da Embrapa Agroindústria de Alimentos. Para informações adicionais entre em contato com ctaa.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Agroindústria de Alimentos. |
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Data corrente: |
16/12/2020 |
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Data da última atualização: |
05/02/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
ROMUALDO, G. R.; SOUZA, I. P. de; SOUZA, L. V. de; PRATA, G. B.; FRAGA-SILVA, T. F. de; SARTORI, A.; BORGUINI, R. G.; SANTIAGO, M. C. P. de A.; FERNANDES, A. A. H.; COGLIATI, B.; BARBOSAN, L. F. |
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Afiliação: |
Guilherme Ribeiro Romualdo, UNESP; Isadora Penedo de Souza, UNESP; Lucas Vilhegas de Souza, UNESP; Gabriel Bacil Prata, UNESP; Thais Fernanda de Campos Fraga-Silva, UNESP; Alexandrina Sartori, UNESP; RENATA GALHARDO BORGUINI, CTAA; MANUELA CRISTINA P DE A SANTIAGO, CTAA; Ana Angélica Henrique Fernandes, UNESP; Bruno Cogliati, USP; Luís Fernando Barbisan, UNESP. |
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Título: |
Beneficial effects of anthocyanin-rich peels of Myrtaceae fruits on chemically-induced liver fibrosis and carcinogenesis in mice. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Food Research International, v. 139, 109964, 2021. p. 1-11. |
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DOI: |
https://doi.org/10.1016/j.foodres.2020.109964 |
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Idioma: |
Inglês |
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Conteúdo: |
Hepatocellular carcinoma (HCC) arising from fibrosis/cirrhosis is the most common type of primary liver cancer. Conversely, a higher intake of fruits and vegetables might play a protective role in HCC risk. Recently, Myrtaceae family tropical fruits have raised great interest due to the high levels of anthocyanins especially in their peels, which are usually discarded upon consumption. Anthocyanins are antioxidant pigments known to have beneficial effects in vivo/in vitro cancer bioassays. Thus, we evaluated whether dietary Myrciaria jaboticaba, Syzygium cumini, and Syzygium malaccense fruit peel powders reduce fibrosis and hepatocarcinogenesis in mice. Female C3H/HeJ mice were submitted to the model of diethylnitrosamine/carbon tetrachloride-induced liver fibrosis and carcinogenesis. Concomitantly, mice received a basal diet containing 2% of M. jaboticaba, S. cumini, or S. malaccense fruit peel powders, obtained by convective drying, for 10 weeks. M. jaboticaba peel powder showed the highest levels of total anthocyanins, while S. cumini peel powder displayed the greatest diversity of these pigments. All Myrtaceae family peel powders reduced the serum levels of the liver injury marker alanine aminotransferase. M. jaboticaba peel feeding reduced the incidence of liver preneoplastic foci, hepatocyte proliferation (Ki-67), and the protein levels of hepato-mitogen tumor necrosis factor-alpha (TNF-?). M. jaboticaba peel feeding also diminished liver lipid peroxidation and increased total glutathione levels. S. cumini peel feeding reduced hepatic collagen, lipid peroxidation, and TNF-? levels while increased catalase activity. Although S. malaccense peel powder, which displayed the lowest anthocyanin levels, decreased oxidative stress, and cytokine levels, no effects were observed on liver fibrosis or preneoplastic lesion outcomes. Findings indicate a protective effect of anthocyanin-rich M. jaboticaba and S. cumini peel powder feeding on preneoplastic lesion development and fibrosis, respectively. Results indicate that differential biological responses may be attributed to distinct anthocyanin profiles and levels, assigning a functional/market value to the underutilized peel fraction. MenosHepatocellular carcinoma (HCC) arising from fibrosis/cirrhosis is the most common type of primary liver cancer. Conversely, a higher intake of fruits and vegetables might play a protective role in HCC risk. Recently, Myrtaceae family tropical fruits have raised great interest due to the high levels of anthocyanins especially in their peels, which are usually discarded upon consumption. Anthocyanins are antioxidant pigments known to have beneficial effects in vivo/in vitro cancer bioassays. Thus, we evaluated whether dietary Myrciaria jaboticaba, Syzygium cumini, and Syzygium malaccense fruit peel powders reduce fibrosis and hepatocarcinogenesis in mice. Female C3H/HeJ mice were submitted to the model of diethylnitrosamine/carbon tetrachloride-induced liver fibrosis and carcinogenesis. Concomitantly, mice received a basal diet containing 2% of M. jaboticaba, S. cumini, or S. malaccense fruit peel powders, obtained by convective drying, for 10 weeks. M. jaboticaba peel powder showed the highest levels of total anthocyanins, while S. cumini peel powder displayed the greatest diversity of these pigments. All Myrtaceae family peel powders reduced the serum levels of the liver injury marker alanine aminotransferase. M. jaboticaba peel feeding reduced the incidence of liver preneoplastic foci, hepatocyte proliferation (Ki-67), and the protein levels of hepato-mitogen tumor necrosis factor-alpha (TNF-?). M. jaboticaba peel feeding also diminished liver lipid peroxidation and increas... Mostrar Tudo |
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Thesaurus Nal: |
Anthocyanins; Fruit peels; Myrciaria; Syzygium cumini. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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Marc: |
LEADER 03166naa a2200301 a 4500
001 2128263
005 2021-02-05
008 2021 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.foodres.2020.109964$2DOI
100 1 $aROMUALDO, G. R.
245 $aBeneficial effects of anthocyanin-rich peels of Myrtaceae fruits on chemically-induced liver fibrosis and carcinogenesis in mice.$h[electronic resource]
260 $c2021
520 $aHepatocellular carcinoma (HCC) arising from fibrosis/cirrhosis is the most common type of primary liver cancer. Conversely, a higher intake of fruits and vegetables might play a protective role in HCC risk. Recently, Myrtaceae family tropical fruits have raised great interest due to the high levels of anthocyanins especially in their peels, which are usually discarded upon consumption. Anthocyanins are antioxidant pigments known to have beneficial effects in vivo/in vitro cancer bioassays. Thus, we evaluated whether dietary Myrciaria jaboticaba, Syzygium cumini, and Syzygium malaccense fruit peel powders reduce fibrosis and hepatocarcinogenesis in mice. Female C3H/HeJ mice were submitted to the model of diethylnitrosamine/carbon tetrachloride-induced liver fibrosis and carcinogenesis. Concomitantly, mice received a basal diet containing 2% of M. jaboticaba, S. cumini, or S. malaccense fruit peel powders, obtained by convective drying, for 10 weeks. M. jaboticaba peel powder showed the highest levels of total anthocyanins, while S. cumini peel powder displayed the greatest diversity of these pigments. All Myrtaceae family peel powders reduced the serum levels of the liver injury marker alanine aminotransferase. M. jaboticaba peel feeding reduced the incidence of liver preneoplastic foci, hepatocyte proliferation (Ki-67), and the protein levels of hepato-mitogen tumor necrosis factor-alpha (TNF-?). M. jaboticaba peel feeding also diminished liver lipid peroxidation and increased total glutathione levels. S. cumini peel feeding reduced hepatic collagen, lipid peroxidation, and TNF-? levels while increased catalase activity. Although S. malaccense peel powder, which displayed the lowest anthocyanin levels, decreased oxidative stress, and cytokine levels, no effects were observed on liver fibrosis or preneoplastic lesion outcomes. Findings indicate a protective effect of anthocyanin-rich M. jaboticaba and S. cumini peel powder feeding on preneoplastic lesion development and fibrosis, respectively. Results indicate that differential biological responses may be attributed to distinct anthocyanin profiles and levels, assigning a functional/market value to the underutilized peel fraction.
650 $aAnthocyanins
650 $aFruit peels
650 $aMyrciaria
650 $aSyzygium cumini
700 1 $aSOUZA, I. P. de
700 1 $aSOUZA, L. V. de
700 1 $aPRATA, G. B.
700 1 $aFRAGA-SILVA, T. F. de
700 1 $aSARTORI, A.
700 1 $aBORGUINI, R. G.
700 1 $aSANTIAGO, M. C. P. de A.
700 1 $aFERNANDES, A. A. H.
700 1 $aCOGLIATI, B.
700 1 $aBARBOSAN, L. F.
773 $tFood Research International$gv. 139, 109964, 2021. p. 1-11.
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Registro original: |
Embrapa Agroindústria de Alimentos (CTAA) |
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Biblioteca |
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| Registros recuperados : 55 | |
| 4. |  | DOMINGUES, L. da S.; RIBEIRO, N. D.; MINETTO, C.; SOUZA, J. F. de; ANTUNES, I. F. Metodologias de análise de adaptabilidade e de estabilidade para a identificação de linhagens de feijão promissoras para o cultivo no Rio Grande do Sul. Semina: Ciências Agrárias, Londrina, v. 34, n. 3, p. 1065-1076, maio/jun. 2013| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Clima Temperado. |
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| 5. | | POSSOBOM, M. T. D. F.; RIBEIRO, N. D.; DOMINGUES, L. da S.; CASAGRANDE, C. R. Genetic control of iron concentration in Mesoamerican and Andean common bean seeds. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 50, n. 5, p. 383-391, maio 2015. Título em português: Controle genético da concentração de ferro em sementes de feijão comum mesoamericano e andino.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 7. | | RIBEIRO, N. D.; DOMINGUES, L. da S.; ZEMOLIN, A. E. M.; POSSOBOM, M. T. D. F. Selection of common bean lines with high agronomic performance and high calcium and iron concentrations. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 48, n. 10, p. 1368-1375, out. 2013. Título em português: Seleção de linhagens de feijão com alto desempenho agronômico e elevadas concentrações de cálcio e ferro.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 10. | | HRCHOROVITCH, V. A.; RIBEIRO, R. A.; SULZBACHER, J. B. W.; POSSENTI, J. C.; DOMINGUES, L. da S.; TOMM, G. O. Efeito de épocas de semeadura nas características fenométricas de híbridos de canola. In: SIMPÓSIO LATINO AMERICANO DE CANOLA, 1., 2014, Passo Fundo. Anais... Brasília, DF: Embrapa, 2014. 5 p. Poster 38.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Trigo. |
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| 11. | | DOMINGUES, L.; BELLO, A.; CUNHA, A.; BARROS, A. T. M. de; SILAGHI, C.; PFISTER, K.; PASSOS, L. F. Bioassay and molecular survey of pyrethroid resistance in Brazilian field populations of Rhipicephalus (Boophilus) Microplus. In: TICKS AND TICK-BORNE PATHOGENS INTERNATIONAL CONFERENCE, 7, 2011, Zaragoza, Spain. [Proceedings...]. Zaragoza: Universidad Zaragoza, 2011. p. 248-249. TTP7 Proceedings.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pantanal. |
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| 12. | | AGNOLON, I. C. C.; ESTELLA, B. M.; DOMINGUES, L. F.; FANTATTO, R. R.; FIGUEIREDO, A.; CHAGAS, A. C. de S. Determinação de limites de uso de solventes e emulsificantes na diluição de extratos vegetais em testes in vitro sobre ovos e larvas de isolado resistente de Haemonchus contortus. In: CONGRESSO DE INICIAÇÃO CIENTÍFICA, 17., 2015, São Carlos, SP. Anais... São Carlos, SP: UNICEP: CENIP, 2015| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 13. | | MENDES, M. C.; CALVO, F. D.; MARTINS, J, R.; DOMINGUES, L. N.; KLAFKE, G. M.; BARROS, A. T. M. de. Caracterización poblacional de la resistencia de la garrapata Rhipicephalus (Boophilus) microplus a la cipermetrina, deltametrina y flumetrina en los estados de Rio Grande do Sul, Minas Gerais y Mato Grosso do Sul, Brasil. In: CONGRESO LATINOAMERICANO DE ACAROLOGÍA, 1, 2012, Puebla. Anais... Puebla: Sociedad Mexicana de Entomologia, 2012. p.264-273.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Pantanal. |
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| 17. | | ALEMÁN GAINZA, Y.; DOMINGUES, L. F.; PEREZ, O. P.; CHAVES, F. C. M.; BIZZO, H. R.; ESTEVES, S. N.; LOPEZ, E. R.; CHAGAS, A. C. de S. Evaluación in vitro de la actividad antihelmíntica del aceite esencial de Piper aduncum contra aislados resistente y sensíble de Haemonchus contortus. In: XXIV CONGRESO PANAMERICANO DE CIENCIAS VETERINARIAS, anais., 2014.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Amazônia Ocidental. |
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| 18. | | ALEMÁN GAINZA, Y.; DOMINGUES, L. F.; PEREZ, O. P.; CHAVES, F. C. M.; BIZZO, H. R.; ESTEVES, S. N.; LOPEZ, E. R.; CHAGAS, A. C. de S. Evaluación in vitro de la actividad antihelmíntica del aceite esencial de Piper aduncum contra aislados resistente y sensíble de Haemonchus contortus. In: XXIV CONGRESO PANAMERICANO DE CIENCIAS VETERINARIAS, anais., 2014.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 20. | | MARSARO, C. B.; NAKAJIMA, N. Y.; MACHADO, S. do A.; MELO, L. O.; RUSCHEL, A. R.; CASTRO, L. C. de; DOMINGUES, L.; SILVA, S. A. Eficiência relativa de duas configurações de parcelas de área fixa para inventário do potencial madeireiro na Amazônia Oriental. Nativa, Sinop, v. 5, n. esp., p. 574-580, dez. 2017.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 2 |
| Biblioteca(s): Embrapa Amazônia Oriental. |
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| Registros recuperados : 55 | |
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