| |
|
|
 | Acesso ao texto completo restrito à biblioteca da Embrapa Suínos e Aves. Para informações adicionais entre em contato com cnpsa.biblioteca@embrapa.br. |
|
Registro Completo |
|
Biblioteca(s): |
Embrapa Suínos e Aves. |
|
Data corrente: |
28/11/2019 |
|
Data da última atualização: |
06/12/2019 |
|
Tipo da produção científica: |
Artigo em Periódico Indexado |
|
Autoria: |
MOREIRA, G. C. M.; POLETI, M. D.; PÉRTILLE, F.; BOSCHIERO, C.; CESAR, A. S. M.; GODOY, T. F.; LEDUR, M. C.; REECY, J. M.; GARRICK, D. J.; COUTINHO, L. L. |
|
Afiliação: |
GABRIEL COSTA MONTEIRO MOREIRA, USP; USP; USP; CLARISSA BOSCHIERO, USP; ALINE SILVA MELLO CESAR, USP; THAIS FERNANDA GODOY, USP; MONICA CORREA LEDUR, CNPSA; JAMES M. REECY, USP; DORIAN J. GARRICK, USP; LUIZ LEHMANN COUTINHO, USP. |
|
Título: |
Unraveling genomic associations with feed efficiency and body weight traits in chickens through an integrative approach. |
|
Ano de publicação: |
2019 |
|
Fonte/Imprenta: |
BMC Genetics, v. 20, n. 83, 2019. |
|
Idioma: |
Inglês |
|
Conteúdo: |
Abstract Background: Feed efficiency and growth rate have been targets for selection to improve chicken production. The incorporation of genomic tools may help to accelerate selection. We genotyped 529 individuals using a high-density SNP chip (600 K, Affymetrix®) to estimate genomic heritability of performance traits and to identify genomic regions and their positional candidate genes associated with performance traits in a Brazilian F2 Chicken Resource population. Regions exhibiting selection signatures and a SNP dataset from resequencing were integrated with the genomic regions identified using the chip to refine the list of positional candidate genes and identify potential causative mutations. Results: Feed intake (FI), feed conversion ratio (FC), feed efficiency (FE) and weight gain (WG) exhibited low genomic heritability values (i.e. from 0.0002 to 0.13), while body weight at hatch (BW1), 35 days-of-age (BW35), and 41 days-of-age (BW41) exhibited high genomic heritability values (i.e. from 0.60 to 0.73) in this F2 population. Twenty unique 1-Mb genomic windows were associated with BW1, BW35 or BW41, located on GGA1?4, 6?7, 10, 14, 24, 27 and 28. Thirty-eight positional candidate genes were identified within these windows, and three of them overlapped with selection signature regions. Thirteen predicted deleterious and three high impact sequence SNPs in these QTL regions were annotated in 11 positional candidate genes related to osteogenesis, skeletal muscle development, growth, energy metabolism and lipid metabolism, which may be associated with body weight in chickens. Conclusions: The use of a high-density SNP array to identify QTL which were integrated with whole genome sequence signatures of selection allowed the identification of candidate genes and candidate causal variants. One novel QTL was detected providing additional information to understand the genetic architecture of body weight traits. We identified QTL for body weight traits, which were also associated with fatness in the same population. Our findings form a basis for further functional studies to elucidate the role of specific genes in regulating body weight and fat deposition in chickens, generating useful information for poultry breeding programs. MenosAbstract Background: Feed efficiency and growth rate have been targets for selection to improve chicken production. The incorporation of genomic tools may help to accelerate selection. We genotyped 529 individuals using a high-density SNP chip (600 K, Affymetrix®) to estimate genomic heritability of performance traits and to identify genomic regions and their positional candidate genes associated with performance traits in a Brazilian F2 Chicken Resource population. Regions exhibiting selection signatures and a SNP dataset from resequencing were integrated with the genomic regions identified using the chip to refine the list of positional candidate genes and identify potential causative mutations. Results: Feed intake (FI), feed conversion ratio (FC), feed efficiency (FE) and weight gain (WG) exhibited low genomic heritability values (i.e. from 0.0002 to 0.13), while body weight at hatch (BW1), 35 days-of-age (BW35), and 41 days-of-age (BW41) exhibited high genomic heritability values (i.e. from 0.60 to 0.73) in this F2 population. Twenty unique 1-Mb genomic windows were associated with BW1, BW35 or BW41, located on GGA1?4, 6?7, 10, 14, 24, 27 and 28. Thirty-eight positional candidate genes were identified within these windows, and three of them overlapped with selection signature regions. Thirteen predicted deleterious and three high impact sequence SNPs in these QTL regions were annotated in 11 positional candidate genes related to osteogenesis, skeletal muscle development... Mostrar Tudo |
|
Palavras-Chave: |
Características de desempenho; Genomic heritability; Genotypic data; GWAS; Herdabilidade genômica; Performance traits. |
|
Thesagro: |
Frango de Corte; Genoma; Seleção Genótipa. |
|
Categoria do assunto: |
-- |
|
Marc: |
LEADER 03240naa a2200337 a 4500
001 2115438
005 2019-12-06
008 2019 bl uuuu u00u1 u #d
100 1 $aMOREIRA, G. C. M.
245 $aUnraveling genomic associations with feed efficiency and body weight traits in chickens through an integrative approach.$h[electronic resource]
260 $c2019
520 $aAbstract Background: Feed efficiency and growth rate have been targets for selection to improve chicken production. The incorporation of genomic tools may help to accelerate selection. We genotyped 529 individuals using a high-density SNP chip (600 K, Affymetrix®) to estimate genomic heritability of performance traits and to identify genomic regions and their positional candidate genes associated with performance traits in a Brazilian F2 Chicken Resource population. Regions exhibiting selection signatures and a SNP dataset from resequencing were integrated with the genomic regions identified using the chip to refine the list of positional candidate genes and identify potential causative mutations. Results: Feed intake (FI), feed conversion ratio (FC), feed efficiency (FE) and weight gain (WG) exhibited low genomic heritability values (i.e. from 0.0002 to 0.13), while body weight at hatch (BW1), 35 days-of-age (BW35), and 41 days-of-age (BW41) exhibited high genomic heritability values (i.e. from 0.60 to 0.73) in this F2 population. Twenty unique 1-Mb genomic windows were associated with BW1, BW35 or BW41, located on GGA1?4, 6?7, 10, 14, 24, 27 and 28. Thirty-eight positional candidate genes were identified within these windows, and three of them overlapped with selection signature regions. Thirteen predicted deleterious and three high impact sequence SNPs in these QTL regions were annotated in 11 positional candidate genes related to osteogenesis, skeletal muscle development, growth, energy metabolism and lipid metabolism, which may be associated with body weight in chickens. Conclusions: The use of a high-density SNP array to identify QTL which were integrated with whole genome sequence signatures of selection allowed the identification of candidate genes and candidate causal variants. One novel QTL was detected providing additional information to understand the genetic architecture of body weight traits. We identified QTL for body weight traits, which were also associated with fatness in the same population. Our findings form a basis for further functional studies to elucidate the role of specific genes in regulating body weight and fat deposition in chickens, generating useful information for poultry breeding programs.
650 $aFrango de Corte
650 $aGenoma
650 $aSeleção Genótipa
653 $aCaracterísticas de desempenho
653 $aGenomic heritability
653 $aGenotypic data
653 $aGWAS
653 $aHerdabilidade genômica
653 $aPerformance traits
700 1 $aPOLETI, M. D.
700 1 $aPÉRTILLE, F.
700 1 $aBOSCHIERO, C.
700 1 $aCESAR, A. S. M.
700 1 $aGODOY, T. F.
700 1 $aLEDUR, M. C.
700 1 $aREECY, J. M.
700 1 $aGARRICK, D. J.
700 1 $aCOUTINHO, L. L.
773 $tBMC Genetics$gv. 20, n. 83, 2019.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Suínos e Aves (CNPSA) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
|
| Registros recuperados : 35 | |
| 1. |  | FRENEAU, G. E.; CARVALHO, S. F. M.; MORAIS, S. M. T. S.; FRENEAU, B. N. Aspects of spermatogenesis and microscopic testicular morphology in Greater Rhea, Rhea americana (Linnaeus, 1758). Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 36, n. 10, p. 1045-1952, out. 2016.| Biblioteca(s): Embrapa Unidades Centrais. |
|    |
| 3. | | SAMPAIO, C. G.; MORAIS, S. M.; RUFINO, M. do S. M.; ALVES, R. E.; BRITO, E. S. de. Quality, bioactive compound content, and antioxidant activity in fruits of brazilian acerola clones. Acta Horticulturae, n. 841, p. 463-466, 2009.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 2 |
| Biblioteca(s): Embrapa Agroindústria Tropical. |
|  |
| 4. | | BARBOSA, C. O.; MORAIS, S. M.; VIEIRA, I. G. P.; PEREIRA, R. de C. A.; CARIOCA, J. O. B. Óleo essencial de manjericão (Ocimum campechianum): química e potencial antioxidante como ingrediente funcional. Revista Interdisciplinar Ciências e Saúde, Teresina, v. 4, n. 4, p. 171-175, 2017.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: C - 0 |
| Biblioteca(s): Embrapa Agroindústria Tropical. |
| |
| 5. | | CAVALCANTE, G. S.; RIBEIRO, W. L. C.; ANDRÉ, W. P. P.; ARAUJO FILHO, J. V.; MUNIZ, C. R.; BEVILAQUA, C. M. L.; MORAIS, S. M. Alterações ultraestruturais em Haemonchus contortus expostos ao látex de Calotropis procera. In: CONGRESSO BRASILEIRO DE PARASITOLOGIA VETERINÁRIA, 20., 2018, Londrina, PR. Anais... Londrina, PR: CBPV; UEL, 2018. p.285. 17 a 19 de setembro de 2018.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Agroindústria Tropical. |
| |
| 6. | | BARBOSA, C. O.; SOUSA, H. A.; RODRIGUES, A. L. M.; PEREIRA, R. de C. A.; VIEIRA, I. G. P.; MORAIS, S. M.; CARIOCA, J. O. B. Chemical characterization, antioxidant and antiacetylcholinesterase activities from the essential oil Ocimum sp. In: SIMPÓSIO LATINO AMERICANO DE CIÊNCIA DE ALIMENTOS (SLACA), 11., 2015, Campinas. Anais... Campinas: Unicamp, 2015.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agroindústria Tropical. |
| |
| 10. | | ROSA, M. de F.; BRITO, E.; PINTO, G. S.; CRISÓSTOMO, L. A.; LEITÃO, R. C.; MORAIS, S. M.; MAZZETTO, S. E. Potencialidades de aplicação do líquido da casca de coco verde. In: CASSEL, E.; VARGAS, R. M. F. (Org.). Aplicaciones industriales de los Taninos vegetales: productos y processos. Porto Alegre: EDIPUCRS, cap.6, p.57-68, 2007.| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Agroindústria Tropical. |
| |
| 11. | | OLIVEIRA, M. S. C.; ALEXANDRINO, C. D.; SILVA, J. A. da; BATISTA, W. P.; BRITO, E. S. de; VIEIRA, Í. G. P.; MORAIS, S. M. de. Perfil lipídico de dois clones comerciais de cajueiro (Anacardium occidentale L.) BRS 274 e 275. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE QUÍMICA, 33., 2010, Águas de Lindóia. Resumos... São Paulo: Sociedade Brasileira de Química, 2010.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agroindústria Tropical. |
| |
| 13. | | MOURA, G. S.; ARAÚJO, S. A. C. de; ASSIS, R. N. de; PINHEIRO, R. R.; DANTAS, T. V. M.; ANDRIOLI, A.; LIMA, F. E. S.; DIAS, R. P.; MELO, V. S. P.; MORAIS, S. M.; TEIXEIRA, M. F. S. Atividade antiviral in vitro de Azadirachta indica A. Juss contra lentivírus de pequenos ruminantes. In: CONGRESSO BRASILEIRO DE MEDICINA VETERINÁRIA, 37., 2010, Rio de Janeiro. Alimento e biosseguranção para o Brasil e o mundo: trabalhos científicos apresentados. Rio de Janeiro: SOMERJ: SBMV, 2010. 1 f. 1 CD-ROM.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
| |
| 14. | | ASSIS, R. N. de; ARAÚJO, S. A. D. de; MOURA, G. S.; PINHEIRO, R. R.; DANTAS, T. V. M.; ANDRIOLI, A.; LIMA, F. E. S.; DIAS, R. P.; MELO, V. S. P.; MORAIS, S. M.; TEIXEIRA, M. F. S. Atividade antiviral in vitro de Melia azedarach L. contra lentivírus de pequenos ruminantes. In: CONGRESSO BRASILEIRO DE MEDICINA VETERINÁRIA, 37., 2010, Rio de Janeiro. Alimento e biosseguranção para o Brasil e o mundo: trabalhos científicos apresentados. Rio de Janeiro: SOMERJ: SBMV, 2010. 1 f. 1 CD-ROM.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
| |
| 15. | | MACIEL, M. V.; MORAIS, S. M.; BEVILAQUA, C. M. L.; SILVA, R. A.; BARROS, R. S.; SOUSA, R. N.; SOUSA, L. C.; MACHADO, L. K. A.; BRITO, E. S. de; SOUZA NETO, M. A. de. Atividade inseticida in vitro do óleo de sementes de nim sobre Lutzomyia longipalpis (Diptera: Psychodidae). Revista Brasileira de Parasitologia Veterinária, Jaboticabal, v. 19, n. 1, p. 7-11, 2010.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 3 |
| Biblioteca(s): Embrapa Agroindústria Tropical. |
| |
| 16. | | CAMURÇA-VASCONCELOS, A. L. F.; BEVILAQUA, C. M. L.; MORAIS, S. M.; MACIEL, M. V.; COSTA, C. T. C.; MACEDO, I. T. F.; OLIVEIRA, L. M. B.; BRAGA, R. R.; SILVA, R. A.; VIEIRA, L. da S. Anthelmintic activity of Croton zehntneri and Lippia sidoides essential oils. Veterinary Parasitology, v. 148, n. 3/4, p. 288-294, Nov. 2007.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: Internacional - A |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
| |
| 17. | | FARIAS, S. S. DE; SANTOS, L. M. B. DOS; CUNHA, A. P.; OLIVEIRA, D. F. DE; PEREIRA, R. de C. A.; GUEDES, M. I. F.; RICARDO, N. M. P. S.; MORAIS, S. M. DE. Análise por infravermelho e citotoxicidade das micropartículas de óleos essenciais de Ocimum Gratissimum L. E Cymbopogon Citratus (D.C.) stapf. Brazilian Journal of Development, São José dos Pinhais, v. 6, n. 7, p. 44954-44960, jul. 2020. Título em inglês: Infrared And Cytotoxicity Analysis Of Microparticles Of Essential Oils Of Ocimum Gratissimum L. And Cymbopogon Citratus (D.C.) Stapf.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 5 |
| Biblioteca(s): Embrapa Agroindústria Tropical. |
| |
| 18. | | SOUSA, A. L. M. de; PINHEIRO, R. R.; ARAÚJO, J. F.; PEIXOTO, R. M.; LIMA, A. M. C.; MORAIS, S. M. de; SOUZA, S. C. R.; AMARAL, G. P.; TEIXEIRA, M. F. da S.; ANDRIOLI, A. Antiviral activity of Azadirachta indica A. Juss and Melia azedarach extracts during the replication cycle of small ruminant lentiviruses. Brazilian Journal of Microbiology, Apr. 2025.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
| |
| 19. | | MACIEL, M. V.; MORAIS, S. M.; BEVILAQUA, C. M. L.; SILVA, R. A.; BARROS, R. S.; SOUSA, R. N.; SOUSA, L. C.; BRITO, E. S. de; SOUZA NETO, M. A. de. Chemical composition of Eucalyptus spp. essential oils and their insecticidal effects on Lutzomyia longipalpis. Veterinary Parasitology, v. 167, n. 1, p. 1-7, 2009.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Agroindústria Tropical. |
| |
| 20. | | MORAIS, S. M. de; FACUNDO, V. A.; BERTINI, L. M.; CAVALCANTI, E. S. B.; ANJOS JÚNIOR, J. F. dos; FERREIRA, S. A.; BRITO, E. S. de; SOUZA NETO, M. A. de. Chemical composition and larvicidal activity of essential oils from Piper species. Biochemical Systematics and Ecology, Pensilvania, v.35, n.10. p.670-675, out. 2007.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: Internacional - A |
| Biblioteca(s): Embrapa Agroindústria Tropical. |
| |
| Registros recuperados : 35 | |
|
| Expressão de busca inválida. Verifique!!! |
|
|
