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 | Acesso ao texto completo restrito à biblioteca da Embrapa Amazônia Oriental. Para informações adicionais entre em contato com cpatu.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Amazônia Oriental. |
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Data corrente: |
06/10/2017 |
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Data da última atualização: |
22/12/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
GHIZONI, C. V. C.; AMES, A. P. A.; LAMEIRA, O. A.; AMADO, C. A. B.; NAKANISHI, A. B. S.; BRACHT, L.; NATALI, M. R. M.; PERALTA, R. M.; BRACHT, A.; COMAR, J. F. |
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Afiliação: |
Cristiane V. Castro Ghizoni, UEM; Ana P. Arssufi Ames, UEM; OSMAR ALVES LAMEIRA, CPATU; Ciomar A. Bersani Amado, UEM; Anacharis B. Sá Nakanishi, UEM; Lívia Bracht, UEM; Maria R. Marçal Natali, UEM; Rosane M. Peralta, UEM; Adelar Bracht, UEM; Jurandir F. Comar, UEM. |
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Título: |
Anti-inflammatory and antioxidant actions of Copaiba oil are related to liver cell modifications in arthritic rats. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
Journal of Cellular Biochemistry, v. 118, n. 10, p. 3409-3423, 2017. |
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DOI: |
10.1002/jcb.25998 |
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Idioma: |
Inglês |
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Conteúdo: |
The present study investigated the action of copaiba oil (Copaifera reticulata) on the systemic inflammation, oxidative status, and liver cell metabolism of rats with adjuvant-induced arthritis. The later is an experimental autoimmune pathology that shares many features with the human rheumatoid arthritis. Holtzman rats were distributed into the following groups: control (healthy) rats; control rats treated with copaiba oil at the doses of 0.58 and 1.15, arthritic rats, and arthritic rats treated with copaiba oil . The oil was administrated orally once a day during 18 days after arthritis induction. Both doses of copaiba oil improved the paw edema and the dose of improved the swollen adrenals and lymph nodes besides decreasing the plasmatic myeloperoxidase activity (30%) of arthritic rats. Copaiba oil abolished the increases of protein carbonyl groups and reactive oxygen species in the liver and both doses increased the liver GSH content and the catalase activity in arthritic rats. Copaiba oil decreased glycolysis (65%), glycogenolysis (58%), and gluconeogenesis (30%) in the liver of arthritic animals. However, gluconeogenesis was also diminished by the treatment of control rats, which presented lower body weight gain (45%) and diminished number of hepatocytes per liver area (20%) associated to higher liver weight (+29%) and increased hepatocyte area (+13%). The results reveal that copaiba oil presented systemic anti-inflammatory and antioxidant actions in arthritic rats. These beneficial effects, however, were counterbalanced by harmful modifications in the liver cell metabolism and morphology of healthy control rats. J. MenosThe present study investigated the action of copaiba oil (Copaifera reticulata) on the systemic inflammation, oxidative status, and liver cell metabolism of rats with adjuvant-induced arthritis. The later is an experimental autoimmune pathology that shares many features with the human rheumatoid arthritis. Holtzman rats were distributed into the following groups: control (healthy) rats; control rats treated with copaiba oil at the doses of 0.58 and 1.15, arthritic rats, and arthritic rats treated with copaiba oil . The oil was administrated orally once a day during 18 days after arthritis induction. Both doses of copaiba oil improved the paw edema and the dose of improved the swollen adrenals and lymph nodes besides decreasing the plasmatic myeloperoxidase activity (30%) of arthritic rats. Copaiba oil abolished the increases of protein carbonyl groups and reactive oxygen species in the liver and both doses increased the liver GSH content and the catalase activity in arthritic rats. Copaiba oil decreased glycolysis (65%), glycogenolysis (58%), and gluconeogenesis (30%) in the liver of arthritic animals. However, gluconeogenesis was also diminished by the treatment of control rats, which presented lower body weight gain (45%) and diminished number of hepatocytes per liver area (20%) associated to higher liver weight (+29%) and increased hepatocyte area (+13%). The results reveal that copaiba oil presented systemic anti-inflammatory and antioxidant actions in arthritic rats. Th... Mostrar Tudo |
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Palavras-Chave: |
Toxicidade. |
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Thesagro: |
Copaíba; Fígado; Metabolismo; Óleo. |
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Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
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Marc: |
LEADER 02525naa a2200301 a 4500
001 2076843
005 2021-12-22
008 2017 bl uuuu u00u1 u #d
024 7 $a10.1002/jcb.25998$2DOI
100 1 $aGHIZONI, C. V. C.
245 $aAnti-inflammatory and antioxidant actions of Copaiba oil are related to liver cell modifications in arthritic rats.$h[electronic resource]
260 $c2017
520 $aThe present study investigated the action of copaiba oil (Copaifera reticulata) on the systemic inflammation, oxidative status, and liver cell metabolism of rats with adjuvant-induced arthritis. The later is an experimental autoimmune pathology that shares many features with the human rheumatoid arthritis. Holtzman rats were distributed into the following groups: control (healthy) rats; control rats treated with copaiba oil at the doses of 0.58 and 1.15, arthritic rats, and arthritic rats treated with copaiba oil . The oil was administrated orally once a day during 18 days after arthritis induction. Both doses of copaiba oil improved the paw edema and the dose of improved the swollen adrenals and lymph nodes besides decreasing the plasmatic myeloperoxidase activity (30%) of arthritic rats. Copaiba oil abolished the increases of protein carbonyl groups and reactive oxygen species in the liver and both doses increased the liver GSH content and the catalase activity in arthritic rats. Copaiba oil decreased glycolysis (65%), glycogenolysis (58%), and gluconeogenesis (30%) in the liver of arthritic animals. However, gluconeogenesis was also diminished by the treatment of control rats, which presented lower body weight gain (45%) and diminished number of hepatocytes per liver area (20%) associated to higher liver weight (+29%) and increased hepatocyte area (+13%). The results reveal that copaiba oil presented systemic anti-inflammatory and antioxidant actions in arthritic rats. These beneficial effects, however, were counterbalanced by harmful modifications in the liver cell metabolism and morphology of healthy control rats. J.
650 $aCopaíba
650 $aFígado
650 $aMetabolismo
650 $aÓleo
653 $aToxicidade
700 1 $aAMES, A. P. A.
700 1 $aLAMEIRA, O. A.
700 1 $aAMADO, C. A. B.
700 1 $aNAKANISHI, A. B. S.
700 1 $aBRACHT, L.
700 1 $aNATALI, M. R. M.
700 1 $aPERALTA, R. M.
700 1 $aBRACHT, A.
700 1 $aCOMAR, J. F.
773 $tJournal of Cellular Biochemistry$gv. 118, n. 10, p. 3409-3423, 2017.
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Registro original: |
Embrapa Amazônia Oriental (CPATU) |
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| 4. |  | TAVARES, M. L.; NAKASU, E. Y. T.; MICHEREFF FILHO, M. A begomovirus is a putative causal agent of internerval chlorosis and curling in soybean leaves. Virus Reviews & Research, Belo Horizonte, v. 20, p. 191, Oct. 2015. Supplement 1, Ref. PIV 45. Edição dos Resumos do XXVI Brazilian Congress of Virology, X Mercosur Meeting of Virology. 2015, Florianóplis.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Hortaliças. |
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| 6. | | SUJII, E.; FONTES, E.; PIRES, C.; PAULA, D.; BERNARDES, T.; NAKASU, E.; TOGNI, P. Assessing risks of GM cotton expressing Cry toxin to non-target herbivores: evaluation of aphids on cotton. In: INTERNATIONAL SYMPOSIUM ON THE BIOSAFETY OF GENETICALLY MODIFIED ORGANISMS, 10., 2008, Wellington. Symposium handbook. Wellington: International Society for Biosafety Research, 2008. p.135.| Tipo: Resumo em Anais de Congresso |
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| 7. | | PAULA, D.; MAGALHÃES, M.; SUJII, E.; PIRES, C.; FONTES, E.; NAKASU, E. Assessment of the effects of Cry1ac toxin to the butterfly Chlosyne lacinia. In: INTERNATIONAL SYMPOSIUM ON THE BIOSAFETY OF GENETICALLY MODIFIED ORGANISMS, 10., 2008, Wellington. Symposium handbook. Wellington: International Society for Biosafety Research, 2008. p.134.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 8. | | NAKASU, E. T.; CIAMPI, A. Y.; SALOMÃO, A. N.; SEVILHA, A. C.; VIEIRA, D.; SCARIOT, A. Aplicação de marcadores microssatélites em Amburana cearensis e Cedrella fissilis na definição de estratégias de conservação. In: ENCONTRO DO TALENTO ESTUDANTIL DA EMBRAPA RECURSOS GENÉTICOS E BIOTECNOLOGIA, 10., 2005, Brasília, DF. Anais: resumos dos trabalhos. Brasília, DF: Embrapa Recursos Genéticos e Biotecnologia, 2005. p. 177.| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 9. | | SOUZA, T. A. de; NAKASU, E. Y. T.; VARGAS, J. R.; INOUE-NAGATA, A. K. Aplicação tópica de moléculas de RNA de fita dupla visando o gene do nucleocapsídeo confere proteção contra groundnut ringspot virus. In: CONGRESSO BRASILEIRO DE FITOPATOLOGIA, 53., Brasília, DF, 2023. Anais...Brasília, DF: Sociedade Brasileira de Fitopatologia, 2023. p. 704.| Tipo: Resumo em Anais de Congresso |
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| 12. | | CATELAN, R. C.; NAKASU, E. Y. T.; VIEIRA, D. L. M.; CIAMPI, A. V.; SCARIOT, A. Análise da variabilidade genética de cerejeira Amburana cearensis utilizando marcador molecular rapd. ENCONTRO DO TALENTO ESTUDANTIL DA EMBRAPA RECURSOS GENETICOS E BIOTECNOLOGIA, 8., 2003, Brasília, DF. Anais: resumos dos trabalhos. Brasília, DF: Embrapa Recursos Genéticos e Biotecnologia, 2003. p. 61| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 14. | | VARGAS, J.; ASSIS, O.; NAKASU, E. Y. T.; INOUE-NAGATA, A. K. Chitosan nanocapsules can successfully protect tomato plants against tomato mosaic virus infection in a dose-dependent manner. In: INTERNATIONAL SYMÓSIUM ON TOMATO DISEASES, 7., 2024, Brasília, DF. Abstracts. Brasília, DF: ISHS, 2024. Disponível em: https://7istd.com/. p. 22.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Hortaliças. |
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| 15. | | REGO, C. M.; NAKASU, E. Y. T.; INOUE-NAGATA, A. K. Begomovirus diversity in resistant and susceptible tomato plants. Virus Reviews and Research, Belo Horizonte, v. 20, p. 192, 2015. Supplement 1, ref. PIV 48. Edição dos Resumos do XXVI Brazilian Congress of Virology, X Mercour Meeting of Virology, 2015, Florianópolis.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Hortaliças. |
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| 17. | | FRAGOSO, R. da R.; NAKASU, E. Y. T.; ROCHA, T. L.; ROSA, A. J. de M. Genômica funcional. In: FALEIRO, F. G.; ANDRADE, S. R. M. de; REIS JUNIOR, F. B. dos. (Ed.). Biotecnologia: estado da arte e aplicações na agropecuária. Planaltina, DF: Embrapa Cerrados, 2011. 729 p. il. Color. p. 143-173| Tipo: Capítulo em Livro Técnico-Científico |
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| 18. | | NAKASU, E. Y. T.; FIRMINO, A. A. P.; DIAS, S. C.; GROSSI-de-SÁ, M. F. Identificação de receptores do bicudo do algodoeiro (Anthonomus grandis) para toxinas cry. In : ENCONTRO DO TALENTO ESTUDANTIL DA EMBRAPA RECURSOS GENÉTICOS E BIOTECNOLOGIA, 12., 2007, Brasília, DF. Anais: resumos dos trabalhos. Brasília, DF: Embrapa Recursos Genéticos e Biotecnologia, 2007. p. 71.| Tipo: Resumo em Anais de Congresso |
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| 19. | | LIMA, M. F.; RIBEIRO, S. da G.; NAGATA, A. K. I.; NAKASU, E. Y. T. Identification of a potatoinfecting begomovirus in the central region of Brazil. Virus Reviews and Research, v. 20, n. 2, p. 145, 2016. Edição dos resumos do XXVII Brazilian Congress of Virology & XI Mercosur Meeting of Virology, Pirienópolis, GO, 2016. Na publicação: Inoue Nagata, A. K. Resumo PIV239.| Tipo: Resumo em Anais de Congresso |
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| Registros recuperados : 95 | |
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