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 | Acesso ao texto completo restrito à biblioteca da Embrapa Agroindústria de Alimentos. Para informações adicionais entre em contato com ctaa.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Agroindústria de Alimentos. |
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Data corrente: |
02/12/2016 |
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Data da última atualização: |
25/09/2017 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
TONUCCI, L. B.; SANTOS, K. M. O. dos; OLIVEIRA, L. L. de; RIBEIRO, S. M. R.; MARTINO, H. S. D. |
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Afiliação: |
Livia Bordalo Tonucci, INTA; KARINA MARIA OLBRICH DOS SANTOS, CTAA; Leandro Licursi de Oliveira, UFV; Sonia Machado Rocha Ribeiro, UFV; Hercia Stampini Duarte Martino, UFV. |
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Título: |
Clinical application of probiotics in type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled study. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
Clinical Nutrition, v. 36, n. 1, p. 85-92, 2017. |
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DOI: |
10.1016/j.clnu.2015.11.011. |
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Idioma: |
Inglês |
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Conteúdo: |
Background & aims: Type 2 diabetes has been associated with dysbiosis and one of the possible routes to restore a healthy gut microbiota is by the regular ingestion of probiotics. We aimed to investigate the effects of probiotics on glycemic control, lipid profile, inflammation, oxidative stress and short chain fatty acids in T2D. Methods: In a double-blind, randomized, placebo-controlled trial, 50 volunteers consumed daily 120 g/d of fermented milk for 6 wk. Participants were assigned into two groups: probiotic group, consuming fermented milk containing Lactobacillus acidophilus La-5 and Bifidobacterium animalis subsp lactis BB-12 (109 colony-forming units/d, each) and control group, consuming conventional fermented milk. Anthropometric measurements, body composition, fasting blood and faecal samples were taken at baseline and after 6 wk. Results: 45 subjects out of 50 (90%) completed follow-up. After 6 wk, there was a significant decrease in fructosamine levels (9.91 mmol/L; p ¼ 0.04) and hemoglobin A1c tended to be lower (0.67%; p ¼ 0.06) in probiotic group. TNF-a and resistin were significantly reduced in probiotic and control groups (1.5 and 1.3 pg/mL, .1 and 2.8 ng/mL, respectively), while IL-10 was significantly reduced ( 0.65 pg/mL; p < 0.001) only in the control group. Fecal acetic acid was increased in both groups (0.58 and 0.59% in probiotic and control groups, respectively; p < 0.01). There was a significant difference between groups concerning mean changes of HbA1c (þ0.31 for control group vs 0.65 for probiotic group; p ¼ 0.02), total cholesterol (þ0.55 for control group vs 0.15 for probiotic group; p ¼ 0.04) and LDL-cholesterol (þ0.36 for control group vs 0.20 for probiotic group p ¼ 0.03). Conclusions: Probiotic consumption improved the glycemic control in T2D subjects, however, the intake of fermented milk seems to be involved with others metabolic changes, such as decrease in inflammatory cytokines (TNF-a and resistin) and increase in the acetic acid. MenosBackground & aims: Type 2 diabetes has been associated with dysbiosis and one of the possible routes to restore a healthy gut microbiota is by the regular ingestion of probiotics. We aimed to investigate the effects of probiotics on glycemic control, lipid profile, inflammation, oxidative stress and short chain fatty acids in T2D. Methods: In a double-blind, randomized, placebo-controlled trial, 50 volunteers consumed daily 120 g/d of fermented milk for 6 wk. Participants were assigned into two groups: probiotic group, consuming fermented milk containing Lactobacillus acidophilus La-5 and Bifidobacterium animalis subsp lactis BB-12 (109 colony-forming units/d, each) and control group, consuming conventional fermented milk. Anthropometric measurements, body composition, fasting blood and faecal samples were taken at baseline and after 6 wk. Results: 45 subjects out of 50 (90%) completed follow-up. After 6 wk, there was a significant decrease in fructosamine levels (9.91 mmol/L; p ¼ 0.04) and hemoglobin A1c tended to be lower (0.67%; p ¼ 0.06) in probiotic group. TNF-a and resistin were significantly reduced in probiotic and control groups (1.5 and 1.3 pg/mL, .1 and 2.8 ng/mL, respectively), while IL-10 was significantly reduced ( 0.65 pg/mL; p < 0.001) only in the control group. Fecal acetic acid was increased in both groups (0.58 and 0.59% in probiotic and control groups, respectively; p < 0.01). There was a significant difference between groups concerning mean changes of Hb... Mostrar Tudo |
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Palavras-Chave: |
Gut microbiota; Oxidative; Type 2 diabetes. |
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Thesagro: |
Stress. |
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Thesaurus Nal: |
inflammation; probiotics. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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Marc: |
null
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Registro original: |
Embrapa Agroindústria de Alimentos (CTAA) |
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| Registros recuperados : 6 | |
| 3. |  | BORBA, R. S. de; SILVA, E. L. da; PACHECO, A. C. S.; PARISE-MALTEMPI, P. P.; ALVES, A. L. Trends in the karyotypic evolution of the Neotropical catfish family Heptapteridae Bockmann 1998 (Teleostei: Siluriformes). Reviews in Fish Biology and Fisheries, London, v. 22, n. 2, p. 509-518, 2012.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Pesca e Aquicultura. |
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| 4. | | FERRAO, R. G.; GAMA, E. E. G; SANTOS, J. A. C.; COSTA, A. F. S.; GALVES, P. A. O.; PACHECO, A. C.; FERRAO, M. A. G. Quatro ciclos de seleção entre e dentro de famílias de meios irmãos na variedade de milho EMCAPA 201. In: CONGRESSO NACIONAL DE MILHO E SORGO, 19.; REUNIAO TECNICA ANUAL DO MILHO, 37.; REUNIAO TECNICA ANUAL DO SORGO, 21., 1992, Porto Alegre. Resumos... Porto Alegre: SSA, 1992. p. 32.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 5. | | PACHECO, A. C. L.; OLIVEIRA, S. M. P.; GOUVEIA, J. J. S.; DINIZ, M. C.; VASCONCELOS, E. J. R.; VIANA, D. de A.; Gracia Maria Soares ROSINHA, G. M. S.; MAGGIONI, R. Analysis of prion protein gene (prnp) polymorphisms in healthy Morada Nova sheep reveals the presence of genotypes susceptible to scrapie. Ciência Animal, v. 17, n. 1, p. 27-36, 2007. Título em português: Análise de polimorfimos do gene da proteína prion (PRNP) em ovinos Morada Nova revela presença de genótipo susceptível ao Scrapie.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: Internacional - C |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 6. | | MARINOTTI, O.; CERQUEIRA, G. C.; ALMEIDA, L. G. P. de; FERRO, M. I. T.; LORETO, E. L. da S.; ZAHA, A.; TEIXEIRA, S. M. R.; WESPISER, A. R.; SILVA, A. A.; SCHLINDWEIN, A. D.; PACHECO, A. C. L.; SILVA, A. L. da C.; GRAVELEY, B. R.; WALENZ, B. P.; LIMA, B. de A.; RIBEIRAO, C. A. G.; NUNES-SILVA, C. G.; CARVALHO, C. R. de; SOARES, C. M. de A.; MENEZES, C. B. A. de; MATIOLLI, C.; CAFFREY, D.; ARAÚJO, D. A. M.; OLIVEIRA, D. M. de; GOLENBOCK, D.; GRISARD, E. C.; FANTINATTI-GARBOGGINI, F.; CARVALHO, F. M. de; BARCELLOS, F. G.; PROSDOCIMI, F.; MAY, G.; AZEVEDO JUNIOR, G. M. de; GUIMARÃES, G. M.; OLDMAN, G. H.; PADILHA, I. Q. M.; BATISTA, J. da S.; FERRO, J. A.; RIBEIRO, J. M. C.; FIETTO, J. L. R.; DABBAS, K. M.; CERDEIRA, L.; AGNEZ-LIMA, L. F.; BROCCHI, M.; CARVALHO, M. O. de; TEIXEIRA, M. de M.; MAIA, M. de M. D.; GOLDMAN, M. H. S.; SCHNEIDER, M. P. C.; FELIPE, M. S. S.; HUNGRIA, M.; NICOLÁS, M. F.; PEREIRA, M.; MONTES, A. M.; CANTAO, M. E.; VINCENTZ, M.; RAFAEL, M. S.; SILVERMAN, N.; STOCO, P. H.; SOUZA, R. C.; VICENTINI, R.; GAZZINELLI, R. T. G.; NEVES, R. de O.; SILVA, R.; ASTOLFI-FILHO, S.; MACIEL, T. E. F.; ÜRMÉNYI, T. P.; TADEI, W. P.; CAMARGO, E. P.; VASCONCELOS, A. T. R. de. The Genome of Anopheles darlingi, the main neotropical malaria vector. Nucleic Acid Research, v. 41, n. 15, p. 7387-7400, 2013.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Soja; Embrapa Suínos e Aves. |
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| Registros recuperados : 6 | |
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