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 | Acesso ao texto completo restrito à biblioteca da Embrapa Caprinos e Ovinos. Para informações adicionais entre em contato com cnpc.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos; Embrapa Recursos Genéticos e Biotecnologia. |
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Data corrente: |
23/08/2016 |
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Data da última atualização: |
17/06/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
MUNIZ, M. M. M.; CAETANO, A. R.; McMANUS, C.; CAVALCANTI, L. C. G.; FAÇANHA, D. A. E.; LEITE, J. H. G. M.; FACO, O.; PAIVA, S. R. |
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Afiliação: |
MARIA MALANE MAGALHÃES MUNIZ, UNIVERSIDADE DE BRASÍLIA (UNB); ALEXANDRE RODRIGUES CAETANO, CENARGEN; CONCEPTA MCMANUS, UNIVERSIDADE DE BRASÍLIA (UNB); LILLIAN CRISTINA GOMES CAVALCANTI, UNIVERSIDADE DE BRASÍLIA (UNB); DÉBORA ANDREA EVANGELISTA FAÇANHA, UNIVERSIDADE FEDERAL RURAL DO SEMI-ÁRIDO (UFERSA); JACINARA HODY GURGEL MORAIS LEITE, UNIVERSIDADE FEDERAL RURAL DO SEMI-ÁRIDO (UFERSA); OLIVARDO FACO, CNPC; SAMUEL REZENDE PAIVA, SRI. |
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Título: |
Application of genomic data to assist a community-based breeding program: A preliminary study of coat color genetics in Morada Nova sheep. |
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Ano de publicação: |
2016 |
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Fonte/Imprenta: |
Livestock Science, v. 190, p. 89-93, Aug. 2016. |
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DOI: |
http://dx.doi.org/10.1016/j.livsci.2016.06.006 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: The Brazilian Sheep Breeders' Association recognizes two varieties of the Morada Nova hair breed, white and red. However, the black variety and/or animals with a pigmented nose has frequently been disqualified from genealogical records. Previous studies suggest that this genetic group might be similar to the red variety. Thus, the aim of this study was to conduct a Genome-wide association study (GWAS) to identify genomic regions related to hair color and confirm the position of black relative to other Morada Nova varieties. After quality controls, 48 animals were genotyped for 45.982 SNPs using the OvineSNP50k BeadChip. Estimated Fst values between white and red animals, white and black, and red and black were 10.78% (p<0.00001), 9.23% (p<0.00001), and 2.93% (p<0.00001), respectively. The comparison between white and red (n=30) versus black (n=18) animals revealed 10 highly significant SNPs, most located in a 6.8 Mb window in Oar14 which contains the MC1R gene. Differences between black and red coats are the result of the expression of different alleles of the same gene without directly affecting productive/reproductive characteristics. These two varieties showed low genetic variation, insufficient to define them as different groups, and to increase the breeding herd, the animals with black hair and/or pigmentation of the nose should be used breeding purposes. The results of this study contribute to the discussion of the importance in reconciling conservation, traditional breed standards and breeding of farm animals. MenosAbstract: The Brazilian Sheep Breeders' Association recognizes two varieties of the Morada Nova hair breed, white and red. However, the black variety and/or animals with a pigmented nose has frequently been disqualified from genealogical records. Previous studies suggest that this genetic group might be similar to the red variety. Thus, the aim of this study was to conduct a Genome-wide association study (GWAS) to identify genomic regions related to hair color and confirm the position of black relative to other Morada Nova varieties. After quality controls, 48 animals were genotyped for 45.982 SNPs using the OvineSNP50k BeadChip. Estimated Fst values between white and red animals, white and black, and red and black were 10.78% (p<0.00001), 9.23% (p<0.00001), and 2.93% (p<0.00001), respectively. The comparison between white and red (n=30) versus black (n=18) animals revealed 10 highly significant SNPs, most located in a 6.8 Mb window in Oar14 which contains the MC1R gene. Differences between black and red coats are the result of the expression of different alleles of the same gene without directly affecting productive/reproductive characteristics. These two varieties showed low genetic variation, insufficient to define them as different groups, and to increase the breeding herd, the animals with black hair and/or pigmentation of the nose should be used breeding purposes. The results of this study contribute to the discussion of the importance in reconciling conservation, trad... Mostrar Tudo |
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Palavras-Chave: |
Coat color pigmentation; GWAS; MC1R; Recurso genético animal. |
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Thesagro: |
Marcador genético; Ovino. |
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Thesaurus Nal: |
Animal genetic resources; Genetic markers; genome-wide association study; Sheep. |
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Categoria do assunto: |
G Melhoramento Genético |
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Marc: |
LEADER 02601naa a2200337 a 4500
001 2054043
005 2024-06-17
008 2016 bl uuuu u00u1 u #d
024 7 $ahttp://dx.doi.org/10.1016/j.livsci.2016.06.006$2DOI
100 1 $aMUNIZ, M. M. M.
245 $aApplication of genomic data to assist a community-based breeding program$bA preliminary study of coat color genetics in Morada Nova sheep.$h[electronic resource]
260 $c2016
520 $aAbstract: The Brazilian Sheep Breeders' Association recognizes two varieties of the Morada Nova hair breed, white and red. However, the black variety and/or animals with a pigmented nose has frequently been disqualified from genealogical records. Previous studies suggest that this genetic group might be similar to the red variety. Thus, the aim of this study was to conduct a Genome-wide association study (GWAS) to identify genomic regions related to hair color and confirm the position of black relative to other Morada Nova varieties. After quality controls, 48 animals were genotyped for 45.982 SNPs using the OvineSNP50k BeadChip. Estimated Fst values between white and red animals, white and black, and red and black were 10.78% (p<0.00001), 9.23% (p<0.00001), and 2.93% (p<0.00001), respectively. The comparison between white and red (n=30) versus black (n=18) animals revealed 10 highly significant SNPs, most located in a 6.8 Mb window in Oar14 which contains the MC1R gene. Differences between black and red coats are the result of the expression of different alleles of the same gene without directly affecting productive/reproductive characteristics. These two varieties showed low genetic variation, insufficient to define them as different groups, and to increase the breeding herd, the animals with black hair and/or pigmentation of the nose should be used breeding purposes. The results of this study contribute to the discussion of the importance in reconciling conservation, traditional breed standards and breeding of farm animals.
650 $aAnimal genetic resources
650 $aGenetic markers
650 $agenome-wide association study
650 $aSheep
650 $aMarcador genético
650 $aOvino
653 $aCoat color pigmentation
653 $aGWAS
653 $aMC1R
653 $aRecurso genético animal
700 1 $aCAETANO, A. R.
700 1 $aMcMANUS, C.
700 1 $aCAVALCANTI, L. C. G.
700 1 $aFAÇANHA, D. A. E.
700 1 $aLEITE, J. H. G. M.
700 1 $aFACO, O.
700 1 $aPAIVA, S. R.
773 $tLivestock Science$gv. 190, p. 89-93, Aug. 2016.
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Registro original: |
Embrapa Recursos Genéticos e Biotecnologia (CENARGEN) |
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| 3. |  | HIMMEN, F. D. A.; SOUZA, F. A. de; SILVA-CARDOSO, I. M. de A.; SOUZA, A. L. X. de; PEREIRA, J. E. S. Micropropagation, estimation of DNA methylation during multiplication cycles and mycorrhization of seed-derived Dendrocalamus asper (Schultes f.) Backer ex Heyne. Plant Cell, Tissue and Organ Culture, v. 155, p. 41-56, 2023.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
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