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Registro Completo |
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Biblioteca(s): |
Embrapa Suínos e Aves. |
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Data corrente: |
16/10/2015 |
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Data da última atualização: |
17/02/2016 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
MOREIRA, G. C. M.; GODOY, T. F.; BOSCHIERO, C.; GHEYAS, A. A.; GASPARIN, G.; ANDRADE, S. C. S.; PADUAN, M.; MONTENEGRO, H.; BURT, D. W.; LEDUR, M. C.; COUTINHO, L. L. |
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Afiliação: |
GABRIEL COSTA MONTEIRO MOREIRA, ESALQ; THAYS FERNANDA GODOY, ESALQ; CLARISSA BOSCHIERO, ESALQ; ALMAS A. GHEYAS, University of Edinburgh; GUSTAVO GASPARIN, ESALQ; SONIA CRISTINA DA SILVA ANDRADE, ESALQ; MARCELA PADUAN, ESALQ; HORACIO MONTENEGRO, ESALQ; DAVID W. BURT, University of Edinburgh; MONICA CORREA LEDUR, CNPSA; LUIZ LEHMANN COUTINHO, ESALQ. |
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Título: |
Variant discovery in a QTL region on chromosome 3 associated with fatness in chickens. |
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Ano de publicação: |
2015 |
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Fonte/Imprenta: |
Animal Genetic, v. 46, n. 2, p. 141-147, 2015. |
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DOI: |
10.1111/age.12263 |
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Idioma: |
Inglês |
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Conteúdo: |
Abdominal fat content is an economically important trait in commercially bred chickens. Although many quantitative trait loci (QTL) related to fat deposition have been detected, the resolution for these regions is low and functional variants are still unknown. The current study was conducted aiming at increasing resolution for a region previously shown to have a QTL associated with fat deposition, to detect novel variants from this region and to annotate those variants to delineate potentially functional ones as candidates for future studies. To achieve this, 18 chickens from a parental generation used in a reciprocal cross between broiler and layer lines were sequenced using the Illumina next-generation platform with an initial coverage of 18X/chicken. The discovery of genetic variants was performed in a QTL region located on chromosome 3 between microsatellite markers LEI0161 and ADL0371 (33 595 706?42 632 651 bp). A total of 136 054 unique SNPs and 15 496 unique INDELs were detected in this region, and after quality filtering, 123 985 SNPs and 11 298 INDELs were retained. Of these variants, 386 SNPs and 15 INDELs were located in coding regions of genes related to important metabolic pathways. Loss-of-function variants were identified in several genes, and six of those, namely LOC771163, EGLN1, GNPAT, FAM120B, THBS2 and GGPS1, were related to fat deposition. Therefore, these loss-offunction variants are candidate mutations for conducting further studies on this important trait in chickens. MenosAbdominal fat content is an economically important trait in commercially bred chickens. Although many quantitative trait loci (QTL) related to fat deposition have been detected, the resolution for these regions is low and functional variants are still unknown. The current study was conducted aiming at increasing resolution for a region previously shown to have a QTL associated with fat deposition, to detect novel variants from this region and to annotate those variants to delineate potentially functional ones as candidates for future studies. To achieve this, 18 chickens from a parental generation used in a reciprocal cross between broiler and layer lines were sequenced using the Illumina next-generation platform with an initial coverage of 18X/chicken. The discovery of genetic variants was performed in a QTL region located on chromosome 3 between microsatellite markers LEI0161 and ADL0371 (33 595 706?42 632 651 bp). A total of 136 054 unique SNPs and 15 496 unique INDELs were detected in this region, and after quality filtering, 123 985 SNPs and 11 298 INDELs were retained. Of these variants, 386 SNPs and 15 INDELs were located in coding regions of genes related to important metabolic pathways. Loss-of-function variants were identified in several genes, and six of those, namely LOC771163, EGLN1, GNPAT, FAM120B, THBS2 and GGPS1, were related to fat deposition. Therefore, these loss-offunction variants are candidate mutations for conducting further studies on this important t... Mostrar Tudo |
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Palavras-Chave: |
Gordura abdominal; INDEL; Mapeamento genético; QTL; SNPs. |
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Thesagro: |
Cromossoma; Frango; Galinha; Genética molecular. |
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Thesaurus Nal: |
Abdominal fat; Animal genetics; Chickens; Chromosome mapping; Quantitative trait loci; Single nucleotide polymorphism. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02690naa a2200433 a 4500
001 2026602
005 2016-02-17
008 2015 bl uuuu u00u1 u #d
024 7 $a10.1111/age.12263$2DOI
100 1 $aMOREIRA, G. C. M.
245 $aVariant discovery in a QTL region on chromosome 3 associated with fatness in chickens.$h[electronic resource]
260 $c2015
520 $aAbdominal fat content is an economically important trait in commercially bred chickens. Although many quantitative trait loci (QTL) related to fat deposition have been detected, the resolution for these regions is low and functional variants are still unknown. The current study was conducted aiming at increasing resolution for a region previously shown to have a QTL associated with fat deposition, to detect novel variants from this region and to annotate those variants to delineate potentially functional ones as candidates for future studies. To achieve this, 18 chickens from a parental generation used in a reciprocal cross between broiler and layer lines were sequenced using the Illumina next-generation platform with an initial coverage of 18X/chicken. The discovery of genetic variants was performed in a QTL region located on chromosome 3 between microsatellite markers LEI0161 and ADL0371 (33 595 706?42 632 651 bp). A total of 136 054 unique SNPs and 15 496 unique INDELs were detected in this region, and after quality filtering, 123 985 SNPs and 11 298 INDELs were retained. Of these variants, 386 SNPs and 15 INDELs were located in coding regions of genes related to important metabolic pathways. Loss-of-function variants were identified in several genes, and six of those, namely LOC771163, EGLN1, GNPAT, FAM120B, THBS2 and GGPS1, were related to fat deposition. Therefore, these loss-offunction variants are candidate mutations for conducting further studies on this important trait in chickens.
650 $aAbdominal fat
650 $aAnimal genetics
650 $aChickens
650 $aChromosome mapping
650 $aQuantitative trait loci
650 $aSingle nucleotide polymorphism
650 $aCromossoma
650 $aFrango
650 $aGalinha
650 $aGenética molecular
653 $aGordura abdominal
653 $aINDEL
653 $aMapeamento genético
653 $aQTL
653 $aSNPs
700 1 $aGODOY, T. F.
700 1 $aBOSCHIERO, C.
700 1 $aGHEYAS, A. A.
700 1 $aGASPARIN, G.
700 1 $aANDRADE, S. C. S.
700 1 $aPADUAN, M.
700 1 $aMONTENEGRO, H.
700 1 $aBURT, D. W.
700 1 $aLEDUR, M. C.
700 1 $aCOUTINHO, L. L.
773 $tAnimal Genetic$gv. 46, n. 2, p. 141-147, 2015.
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