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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
16/12/2014 |
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Data da última atualização: |
28/03/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
ALEXANDRE, P. A.; GOMES, R. da C.; SANTANA, M. H. A.; SILVA, S. L.; LEMES, P. R.; MUDADU, M. de A.; REGITANO, L. C. de A.; MEIRELLES, F. V.; FERRAZ, J. B. S.; FUKUMASU, H. |
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Afiliação: |
PÂMELA A. ALEXANDRE, UNIVERSIDADE DE SÃO PAULO/PIRASSUNUNGA; RODRIGO DA COSTA GOMES, CNPGC; MIGUEL H. A. SANTANA, USP/PIRASSUNUNGA; SAULO L. SILVA, UNIVERSIDADE DE SAO PAULO/PIRASSUNUNGA; PAULO R. LEMES, UNIVERSIDADE DE SÃO PAULO/PIRASSUNUNGA; MAURICIO DE ALVARENGA MUDADU, CPPSE; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; FLAVIO V. MEIRELLES, UNIVERSIDADE DE SAO PAULO/PIRASSUNUNGA; JOSÉ B. S. FERRAZ, UNIVERSIDADE DE SAO PAULO/PIRASSUNUNGA; HEIDGE FUKUMASU, UNIVERSIDADE DE SAO PAULO/PIRASSUNUNGA. |
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Título: |
Bovine NR1I3 gene polymorphisms and its association with feed efficiency traits in Nellore cattle. |
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Ano de publicação: |
2014 |
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Fonte/Imprenta: |
Meta Gene, v. 2, p. 206-217, dec. 2014. |
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DOI: |
10.1016/j.mgene.2014.01.003 |
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Idioma: |
Inglês |
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Conteúdo: |
The Nuclear receptor 1 family I member 3 (NR1I3), also known as the Constitutive Androstane Receptor (CAR), was initially characterized as a key regulator of xenobiotic metabolism. However, recent biochemical and structural data suggest that NR1I3 is activated in response to metabolic and nutritional stress in a ligand-independent manner. Thus, we prospected the Bovine NR1I3 gene for polymorphisms and studied their association with feed efficiency traits in Nellore cattle. First, 155 purebredNellore bullswere individuallymeasured for Residual Feed Intake (RFI) and the 25 best (High Feed Efficiency group, HFE) and the 25 worst animals (Low Feed Efficiency group, LFE) were selected for DNA extraction. The entire Bovine NR1I3 gene was amplified and polymorphisms were identified by sequencing. Then, one SNP different between HFE and LFE groupswas genotyped in all the 155 animals and in another 288 animals totalizing 443 Nellore bulls genotyped for association of NR1I3 SNPs with feed efficiency traits. We found 24 SNPs in the NR1I3 gene and choose a statistically different SNP between HFE and LFE groups for further analysis. Genotyping of the 155 animals showed a significant associationwithin SNP and RFI (p = 0.04), Residual Intake and BW Gain (p = 0.04) and Dry Matter Intake (p = 0.01). This SNP is located in the 5′flanking promoter region of NR1I3. |
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Palavras-Chave: |
CAR; NR113 gene; Residual feed intake. |
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Thesaurus Nal: |
beef cattle; Nellore. |
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Categoria do assunto: |
G Melhoramento Genético |
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Marc: |
LEADER 02235naa a2200301 a 4500
001 2002804
005 2023-03-28
008 2014 bl uuuu u00u1 u #d
024 7 $a10.1016/j.mgene.2014.01.003$2DOI
100 1 $aALEXANDRE, P. A.
245 $aBovine NR1I3 gene polymorphisms and its association with feed efficiency traits in Nellore cattle.$h[electronic resource]
260 $c2014
520 $aThe Nuclear receptor 1 family I member 3 (NR1I3), also known as the Constitutive Androstane Receptor (CAR), was initially characterized as a key regulator of xenobiotic metabolism. However, recent biochemical and structural data suggest that NR1I3 is activated in response to metabolic and nutritional stress in a ligand-independent manner. Thus, we prospected the Bovine NR1I3 gene for polymorphisms and studied their association with feed efficiency traits in Nellore cattle. First, 155 purebredNellore bullswere individuallymeasured for Residual Feed Intake (RFI) and the 25 best (High Feed Efficiency group, HFE) and the 25 worst animals (Low Feed Efficiency group, LFE) were selected for DNA extraction. The entire Bovine NR1I3 gene was amplified and polymorphisms were identified by sequencing. Then, one SNP different between HFE and LFE groupswas genotyped in all the 155 animals and in another 288 animals totalizing 443 Nellore bulls genotyped for association of NR1I3 SNPs with feed efficiency traits. We found 24 SNPs in the NR1I3 gene and choose a statistically different SNP between HFE and LFE groups for further analysis. Genotyping of the 155 animals showed a significant associationwithin SNP and RFI (p = 0.04), Residual Intake and BW Gain (p = 0.04) and Dry Matter Intake (p = 0.01). This SNP is located in the 5′flanking promoter region of NR1I3.
650 $abeef cattle
650 $aNellore
653 $aCAR
653 $aNR113 gene
653 $aResidual feed intake
700 1 $aGOMES, R. da C.
700 1 $aSANTANA, M. H. A.
700 1 $aSILVA, S. L.
700 1 $aLEMES, P. R.
700 1 $aMUDADU, M. de A.
700 1 $aREGITANO, L. C. de A.
700 1 $aMEIRELLES, F. V.
700 1 $aFERRAZ, J. B. S.
700 1 $aFUKUMASU, H.
773 $tMeta Gene$gv. 2, p. 206-217, dec. 2014.
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| 1. |  | ARAUJO, V. A. de; GARCIA, J. N.; CORTEZ-BARBOSA, J.; GAVA, M.; SAVI, A. F.; MORALES, E. A. M.; LAHR, F. A. R.; VASCONCELOS, J. S.; CHRISTOFORO, A. L. Importância da madeira de florestas plantadas para a indústria de manufaturados. Pesquisa Florestal Brasileira, Colombo, v. 37, n. 90, p. 189-200, abr./jun. 2017.| Biblioteca(s): Embrapa Florestas. |
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