Data/hora: 25/06/2024 09:24:07

Biblioteca(s): 	Embrapa Caprinos e Ovinos.	
Data corrente: 	01/08/1992	
Data da última atualização: 	26/06/2023	
Autoria: 	YAMAMOTO, Y.; PERIC-GOLIA, L.; OSAWA, Y.; KIRDANI, R. Y.; SANDBERD, A. A.	
Título: 	Androgen metabolism in sheep.	
Ano de publicação: 	1978	
Fonte/Imprenta: 	Steroids, v. 32, n. 3, p. 373-388, Oct., 1978.	
DOI: 	10.1016/0039-128x(78)90089-2.	
Idioma: 	Inglês	
Conteúdo: 	Abstract: 3H-Testosterone (3H-T) plus 14C-androst-4-ene-3,17-dione (A-dione) and 3H-epi-testosterone (17alpha-hydroxy-4-androsten-3-one) (epiT) plus 14C-T were injected intravenously into two male sheep with bile fistulae, respectively. Urine and bile samples were collected at intervals for 4-8 hours and analyzed by the use of DEAE-Sephadex A-25 and Lipidex 5000 columns, TLC, and paper chromatography; the aglycones were identified by co-crystallization with authentic standards. Five fractions were obtained from urine and bile: unconjugated, glucosiduronates, sulfates, sulfo-glucosiduronates and disulfates. In urine, the major conjugates were glucosiduronates, while sulfates predominated in bile. About 80-90% of recovered radioactivity was found to be either glucosiduronates or sulfates. Among the metabolites identified, epi-T was the principal one, accounting for 10-15% of the administered doses. Conversion to 17alpha-hydroxysteroids thus appears to be a major route of metabolism of the androgens administered in sheep. Other metabolites in the glucosiduronate and sulfate fractions were androsterone, etiocholanolone (3alpha-hydroxy-5beta-androstan-17-one), 5beta-androstane-3alpha,17beta-diol, two unknown diols and polar metabolites. The results indicated that androgen metabolism is somewhat unusual in sheep, as compared with other animals and the human.	
Palavras-Chave: 	Time Factors.	
Thesagro: 	Endocrinologia; Fisiologia; Ovino; Reprodução.	
Thesaurus Nal: 	Androgens; Endocrinology; Ion exchange chromatography; Metabolism; Reproduction; Sheep; Sulfates; Urine.	
Categoria do assunto: 	--	
Registro original: 	Embrapa Caprinos e Ovinos (CNPC)	
Exemplares: 	CNPC - (7979-1) - ADD - AP - DD -  -  -  - DIS