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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
14/02/2017 |
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Data da última atualização: |
30/01/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
BARBOSA, J. O.; ROSSONI, R. D.; VILELA, S. F. G.; ALVARENGA, J. A. de; VELLOSO, M. dos S.; PRATA, M. C. de A.; JORGE, A. O. C.; JUNQUEIRA, J. C. |
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Afiliação: |
Júnia Oliveira Barbosa, UNESP; Rodnei Dennis Rossoni, UNESP; Simone Furgeri Godinho Vilela, UNESP; Janaína Araújo de Alvarenga, UNESP; Marisol dos Santos Velloso, UNESP; MARCIA CRISTINA DE AZEVEDO PRATA, CNPGL; Antonio Olavo Cardoso Jorge, UNESP; Juliana Campos Junqueira, UNESP. |
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Título: |
Streptococcus mutans can modulate biofilm formation and attenuate the virulence of Candida albicans. |
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Ano de publicação: |
2016 |
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Fonte/Imprenta: |
Plos One, v. 11, n. 3, e0150457, 2016. |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract Streptococcus mutans and Candida albicans are found together in the oral biofilms on dental surfaces, but little is known about the ecological interactions between these species. Here, we studied the effects of S. mutans UA159 on the growth and pathogencity of C. albicans. Initially, the effects of S. mutans on the biofilm formation and morphogenesis of C. albicans were tested in vitro. Next, we investigate the influence of S. mutans on pathogenicity of C. albicans using in vivo host models, in which the experimental candidiasis was induced in G. mellonella larvae and analyzed by survival curves, C. albicans count in hemolymph, and quantification of hyphae in the host tissues. In all the tests, we evaluated the direct effects of S. mutans cells, as well as the indirect effects of the subproducts secreted by this microorganism using a bacterial culture filtrate. The in vitro analysis showed that S. mutans cells favored biofilm formation by C. albicans. However, a reduction in biofilm viable cells and inhibition of hyphal growth was observed when C. albicans was in contact with the S. mutans culture filtrate. In the in vivo study, injection of S. mutans cells or S. mutans culture filtrate into G. mellonella larvae infected with C. albicans increased the survival of these animals. Furthermore, a reduction in hyphal formation was observed in larval tissues when C. albicans was associated with S. mutans culture filtrate. These findings suggest that S. mutans can secrete subproducts capable to inhibit the biofilm formation, morphogenesis and pathogenicity of C. albicans, attenuating the experimental candidiasis in G. mellonella model. MenosAbstract Streptococcus mutans and Candida albicans are found together in the oral biofilms on dental surfaces, but little is known about the ecological interactions between these species. Here, we studied the effects of S. mutans UA159 on the growth and pathogencity of C. albicans. Initially, the effects of S. mutans on the biofilm formation and morphogenesis of C. albicans were tested in vitro. Next, we investigate the influence of S. mutans on pathogenicity of C. albicans using in vivo host models, in which the experimental candidiasis was induced in G. mellonella larvae and analyzed by survival curves, C. albicans count in hemolymph, and quantification of hyphae in the host tissues. In all the tests, we evaluated the direct effects of S. mutans cells, as well as the indirect effects of the subproducts secreted by this microorganism using a bacterial culture filtrate. The in vitro analysis showed that S. mutans cells favored biofilm formation by C. albicans. However, a reduction in biofilm viable cells and inhibition of hyphal growth was observed when C. albicans was in contact with the S. mutans culture filtrate. In the in vivo study, injection of S. mutans cells or S. mutans culture filtrate into G. mellonella larvae infected with C. albicans increased the survival of these animals. Furthermore, a reduction in hyphal formation was observed in larval tissues when C. albicans was associated with S. mutans culture filtrate. These findings suggest that S. mutans can secrete ... Mostrar Tudo |
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Palavras-Chave: |
Biofilms; Biosupression; Patology. |
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Thesaurus Nal: |
microbiology. |
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Categoria do assunto: |
H Saúde e Patologia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/155632/1/Cnpgl-2016-PlosOne-Streptococcus.PDF
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Marc: |
LEADER 02395naa a2200253 a 4500
001 2064049
005 2023-01-30
008 2016 bl uuuu u00u1 u #d
100 1 $aBARBOSA, J. O.
245 $aStreptococcus mutans can modulate biofilm formation and attenuate the virulence of Candida albicans.$h[electronic resource]
260 $c2016
520 $aAbstract Streptococcus mutans and Candida albicans are found together in the oral biofilms on dental surfaces, but little is known about the ecological interactions between these species. Here, we studied the effects of S. mutans UA159 on the growth and pathogencity of C. albicans. Initially, the effects of S. mutans on the biofilm formation and morphogenesis of C. albicans were tested in vitro. Next, we investigate the influence of S. mutans on pathogenicity of C. albicans using in vivo host models, in which the experimental candidiasis was induced in G. mellonella larvae and analyzed by survival curves, C. albicans count in hemolymph, and quantification of hyphae in the host tissues. In all the tests, we evaluated the direct effects of S. mutans cells, as well as the indirect effects of the subproducts secreted by this microorganism using a bacterial culture filtrate. The in vitro analysis showed that S. mutans cells favored biofilm formation by C. albicans. However, a reduction in biofilm viable cells and inhibition of hyphal growth was observed when C. albicans was in contact with the S. mutans culture filtrate. In the in vivo study, injection of S. mutans cells or S. mutans culture filtrate into G. mellonella larvae infected with C. albicans increased the survival of these animals. Furthermore, a reduction in hyphal formation was observed in larval tissues when C. albicans was associated with S. mutans culture filtrate. These findings suggest that S. mutans can secrete subproducts capable to inhibit the biofilm formation, morphogenesis and pathogenicity of C. albicans, attenuating the experimental candidiasis in G. mellonella model.
650 $amicrobiology
653 $aBiofilms
653 $aBiosupression
653 $aPatology
700 1 $aROSSONI, R. D.
700 1 $aVILELA, S. F. G.
700 1 $aALVARENGA, J. A. de
700 1 $aVELLOSO, M. dos S.
700 1 $aPRATA, M. C. de A.
700 1 $aJORGE, A. O. C.
700 1 $aJUNQUEIRA, J. C.
773 $tPlos One$gv. 11, n. 3, e0150457, 2016.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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| Registros recuperados : 11 | |
| 4. |  | NOVOTNY, E. H.; VELLOSO, M. H. R.; AZEVEDO, E. R. de; BONAGAMBA, T. J.; SONG, G.; HAYES, M. H. B. Extração seletiva da fração húmica característica das terras pretas de índios. In: ENCONTRO BRASILEIRO DE SUBSTÂNCIAS HÚMICAS, 8., 2009, Pelotas. Matéria orgânica ambiental e sustentabilidade: resumos expandidos. Pelotas: Embrapa Clima Temperado, 2009. 1 CD-ROM.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Solos. |
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| 5. | | REZENDE, E. I. P.; MANGONI, A. P.; MESSERSCHMIDT, I.; NOVOTNY, E. H.; VELLOSO, M. H. R.; MANGRICH, A. S. DRUV-VIS analyses in the biochar preparation process. In: INTERNATIONAL BIOCHAR CONFERENCE, 3., 2010, Rio de Janeiro. Progressing from Terra Preta de Índios to the whole world: anais. Rio de Janeiro: Embrapa, 2010.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Solos. |
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| 6. | | REZENDE, E. I. P. de; MANGONI, A. P.; MESSERSCHMIDT, I.; MANGRICH, A. S.; NOVOTNY, E. H.; VELLOSO, M. H. R. Pyrolisis parameters evaluation in the biochar preparation process. In: MEETING OF THE INTERNATIONAL HUMIC SUBSTANCES SOCIETY, 15., 2010, Tenerife. Proceedings... Tenerife: IHSS, 2010. v. 3, p. 274-277.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Solos. |
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| 7. | | NOVOTNY, E. H.; AUCCAISE, R.; VELLOSO, M. H. R.; CORREA, J. C.; HIGARASHI, M. M.; ABREU, V. M. N.; ROCHA, J. D. C-13 and P-31 NMR Analyses of swine bones biochar. In: INTERNATIONAL BIOCHAR CONFERENCE, 3., 2010, Rio de Janeiro. Processing from Terra Preta de Índios to the whole world. Rio de Janeiro: Embrapa Solos, 2010. 1 CD-ROM. (Embrapa Solos. Documentos, 120).| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Solos. |
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| 8. | | NOVOTNY, E. H.; AUCCAISE, R.; VELLOSO, M. R. H.; CORREA, J. C.; HIGARASHI, M. M.; ABREU, V. M. N.; ROCHA, J. D. C-13 and P-31 NMR analyses of swine bones biochar. In: INTERNATIONAL BIOCHAR CONFERENCE, 3., 2010, Rio de Janeiro. Processing from terra preta de índios to the whole world. Brasília, DF: Embrapa: MAPA, 2010. p. 33-34. 1 CD-ROM.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Agroenergia. |
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| 9. | | NOVOTNY, E. H.; AUCCAISE, R.; VELLOSO, M. H. R.; CORRÊA, J. C.; HIGARASHI, M. M.; ABREU, V. M. N.; ROCHA, J. D.; KWAPINSKI, W. Characterization of phosphate structures in biochar from swine bones. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 47, n. 5, p. 672-676, maio 2012.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Agroenergia; Embrapa Solos; Embrapa Suínos e Aves; Embrapa Unidades Centrais. |
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| 10. | | MACHADO-DE-ÁVILA, R. A.; VELLOSO, M.; OLIVEIRA, D.; STRANSKY, S.; FLOR-SÁ, A.; SCHNEIDER, F. S.; NESHICH, G.; CHÁVEZ-OLÓRTEGUI, C. Induction of neutralizing antibodies against mutalysin-II from Lachesis muta muta Snake Venom Elicited by a conformational B-cell epitope predicted by Blue Star Sting data base. Immunome Research, v. 11, n. 1, Mar. 2015. Não paginado.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 3 |
| Biblioteca(s): Embrapa Agricultura Digital. |
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| 11. | | BARBOSA, J. O.; ROSSONI, R. D.; VILELA, S. F. G.; ALVARENGA, J. A. de; VELLOSO, M. dos S.; PRATA, M. C. de A.; JORGE, A. O. C.; JUNQUEIRA, J. C. Streptococcus mutans can modulate biofilm formation and attenuate the virulence of Candida albicans. Plos One, v. 11, n. 3, e0150457, 2016.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Gado de Leite. |
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| Registros recuperados : 11 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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