Data/hora: 23/09/2024 18:39:19

Biblioteca(s): 	Embrapa Amazônia Ocidental.	
Data corrente: 	04/04/2013	
Data da última atualização: 	29/01/2018	
Autoria: 	LIMA, E. S.; PINTO, A. C. S.; NOGUEIRA, K. L.; SILVA, L. F. R. e; ALMEIDA, P. D. O. de; VASCONCELLOS, M. C. de; CHAVES, F. C. M.; TADEI, W. P.; POHLIT, A. M.	
Afiliação: 	Emerson Silva Lima, UFAM; Ana Cristina Silva Pinto, INPA; Karla Lagos Nogueira, INPA; Luiz Francisco Rocha e Silva, INPA; Patricia Danielle Oliveira de Almeida, UFAM; Marne Carvalho de Vasconcellos, UFAM; FRANCISCO CELIO MAIA CHAVES, CPAA; Wanderli Pedro Tadei, INPA; Adrian Martin Pohlit, INPA.	
Título: 	Stability and Antioxidant Activity of Semi-synthetic Derivatives of 4-Nerolidylcatechol.	
Ano de publicação: 	2013	
Fonte/Imprenta: 	Molecules, v. 18, n. 1, p. 178-189, jan. 2013.	
ISSN: 	1420-3049	
DOI: 	10.3390/molecules18010178	
Idioma: 	Inglês	
Conteúdo: 	4-nerolidylcatechol (4-NC) is an unstable natural product that exhibits important antioxidant, anti-inflammatory and other properties. It is readily obtainable on a multi-gram scale through straightforward solvent extraction of the roots of cultivated Piper peltatum or P. umbellatum, followed by column chromatography on the resulting extract. Semi-synthetic derivatives of 4-NC with one or two substituent groups (methyl, acetyl, benzyl, benzoyl) on the O atoms have been introduced that have increased stability compared to 4-NC and significant in vitro inhibitory activity against the human malaria parasite Plasmodium falciparum. Antioxidant and anti-inflammatory properties may be important for the antiplasmodial mode of action of 4-NC derivatives. Thus, we decided to investigate the antioxidant properties, cytotoxicity and stability of 4-NC derivatives as a means to explore the potential utility of these compounds. 4-NC showed high antioxidant activity in the DPPH and ABTS assays and in 3T3-L1 cells (mouse embryonic fibroblast), however 4-NC was more cytotoxic (IC50 = 31.4 µM) and more unstable than its derivatives and lost more than 80% of its antioxidant activity upon storage in solution at &#8722;20 °C for 30 days. DMSO solutions of mono-O-substituted derivatives of 4-NC exhibited antioxidant activity and radical scavenging activity in the DPPH and ABTS assays that was comparable to that of BHA and BHT. In the cell-based antioxidant model, most DMSO solutions of derivatives of 4-NC were less active on day 1 than 4-NC, quercetin and BHA and more active antioxidants than BHT. After storage for 30 days at &#8722;20 °C, DMSO solutions of most of the derivatives of 4-NC were more stable and exhibited more antioxidant activity than 4-NC, quercetin and BHA and exhibited comparable antioxidant activity to BHT. These findings point to the potential of derivatives of 4-NC as antioxidant compounds.	
Palavras-Chave: 	Antioxidantes; Piper peltatum.	
Categoria do assunto: 	--	
URL: 	http://ainfo.cnptia.embrapa.br/digital/bitstream/item/80487/1/molecules-18-00178-v2.pdf	
Registro original: 	Embrapa Amazônia Ocidental (CPAA)	
Exemplares: 	CPAA - (25159-1) - UPC - AP - PP - S9032 -  - S9032 - DIS