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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
06/03/2009 |
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Data da última atualização: |
14/05/2024 |
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Tipo da produção científica: |
Artigo em Anais de Congresso / Nota Técnica |
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Autoria: |
LIU, G. E.; LI, R. W.; SONSTEGARD, T. S.; MATUKUMALLI, L. K.; SILVA, M. V. G. B.; VAN TASSELL, C. P. |
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Afiliação: |
G. E. Liu, USDA-ARS; R.W. LI, USDA-ARS; Tad S. Sonstegard USDA USA; Lakshmi Matukumalli George Mason University USA; Marcos Vinicius Gualberto Barbosa da Silva Embrapa Gado de Leite / USDA USA; Curtis Van Tassell USDA USA. |
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Título: |
Characterization of a novel microdeletion polymorphism on BTA5 in cattle. |
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Ano de publicação: |
2008 |
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Fonte/Imprenta: |
Animal Genetics, v. 39, n. 6, p. 655-658, 2008. |
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DOI: |
https://doi.org/10.1111/j.1365-2052.2008.01769.x |
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Idioma: |
Inglês |
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Conteúdo: |
We present a detailed breakpoint mapping and population frequency analysis of a 214-kb microdeletion that removes multiple olfactory receptor genes. Using progressive rounds of PCR assays, we mapped the upstream and downstream breakpoints of this microdeletion event to 1 and 12 kb genomic regions, respectively. We developed PCR-based genotyping assays, characterized a dairy cattle panel of 96 samples and found that the frequency of the deletion allele was over 51%. Our results indicated that this microdeletion is an ancient event occurring in one of the earlier founders, and that it has been stably inherited across generations in the North American dairy cattle population. |
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Palavras-Chave: |
Breakpoint; Cattle genome; Deletion; Population frequency; Structural variants. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/596819/1/Characterization-of-a-novel-microdeletion-polymorphism-on-BTA5-in-cattle.pdf
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Marc: |
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024 7 $ahttps://doi.org/10.1111/j.1365-2052.2008.01769.x$2DOI
100 1 $aLIU, G. E.
245 $aCharacterization of a novel microdeletion polymorphism on BTA5 in cattle.$h[electronic resource]
260 $c2008
520 $aWe present a detailed breakpoint mapping and population frequency analysis of a 214-kb microdeletion that removes multiple olfactory receptor genes. Using progressive rounds of PCR assays, we mapped the upstream and downstream breakpoints of this microdeletion event to 1 and 12 kb genomic regions, respectively. We developed PCR-based genotyping assays, characterized a dairy cattle panel of 96 samples and found that the frequency of the deletion allele was over 51%. Our results indicated that this microdeletion is an ancient event occurring in one of the earlier founders, and that it has been stably inherited across generations in the North American dairy cattle population.
653 $aBreakpoint
653 $aCattle genome
653 $aDeletion
653 $aPopulation frequency
653 $aStructural variants
700 1 $aLI, R. W.
700 1 $aSONSTEGARD, T. S.
700 1 $aMATUKUMALLI, L. K.
700 1 $aSILVA, M. V. G. B.
700 1 $aVAN TASSELL, C. P.
773 $tAnimal Genetics$gv. 39, n. 6, p. 655-658, 2008.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
