Data/hora: 23/09/2024 20:10:34

Biblioteca(s): 	Embrapa Agroindústria de Alimentos.	
Data corrente: 	03/05/2022	
Data da última atualização: 	10/10/2022	
Autoria: 	MONTENEGRO, J.; FREITAS-SILVA, O.; TEODORO, A. J.	
Afiliação: 	JULIA MONTENEGRO, UNIRIO; OTNIEL FREITAS SILVA, CTAA; ANDERSON JUNGER TEODORO, UNIRIO.	
Título: 	Molecular Mechanisms of Coffee on Prostate Cancer Prevention.	
Ano de publicação: 	2022	
Fonte/Imprenta: 	Biomed Research International, D 3254420, p. 1-12, 2022.	
DOI: 	https://doi.org/10.1155/2022/3254420	
Idioma: 	Inglês	
Notas: 	Review Article.	
Conteúdo: 	Prostate cancer (PCa) is one of the most common types of cancer among men, and coffee is associated with a reduced risk of developing PCa. Therefore, we aim to review possible coffee molecular mechanisms that contribute to PCa prevention. Coffee has an important antioxidant capacity that reduces oxidative stress, leading to a reduced mutation in cells. Beyond direct antioxidant activity, coffee stimulates phase II enzymatic activity, which is related to the detoxification of reactive metabolites. The anti-inflammatory effects of coffee reduce tissue damage related to PCa development. Coffee induces autophagy, regulates the NF-κB pathway, and reduces the expression of iNOS and inflammatory mediators, such as TNF-α, IL-6, IL-8, and CRP. Also, coffee modulates transcriptional factors and pathways. It has been shown that coffee increases testosterone and reduces sex hormone-binding globulin, estrogen, and prostate-specific antigen. Coffee also enhances insulin resistance and glucose metabolism. All these effects may contribute to protection against PCa development.	
Thesaurus Nal: 	Food technology.	
Categoria do assunto: 	--	
Registro original: 	Embrapa Agroindústria de Alimentos (CTAA)	
Exemplares: 	CTAA - (15320-1) - UPC - AP - DD -  -  -  - DIS