Data/hora: 17/06/2024 01:59:25

Biblioteca(s): | Embrapa Gado de Leite.
Data corrente: | 03/12/2018
Data da última atualização: | 24/01/2023
Autoria: | BARROS, P. A. V. de; ANDRADE, M. E. R.; GENEROSO, S. de V.; MIRANDA, S. E. M.; REIS, D. C. dos; LEOCÁDIO, P. C. L.; SOUZA, E. L. de S. e; MARTINS, F. dos S.; GAMA, M. A. S. da; CASSALI, G. D.; LEITE, J. I. A.; FERNANDES, S. O. A.; CARDOSO, V. N.
Afiliação: | PATRÍCIA APARECIDA VIEIRA DE BARROS, UFMG; MARIA EMÍLIA RABELO ANDRADE, UFMG; SIMONE DE VASCONCELOS GENEROSO, UFMG; SUED EUSTÁQUIO MENDES MIRANDA, UFMG; DIEGO CARLOS DOS REIS, UFMG; PAOLA CAROLINE LACERDA LEOCÁDIO, UFMG; ÉRICKA LORENNA DE SALES E SOUZA, UFMG; FLAVIANO DOS SANTOS MARTINS, UFMG; MARCO ANTONIO SUNDFELD DA GAMA, CNPGL; GEOVANNI DANTAS CASSALI, UFMG; JACQUELINE ISAURA ALVAREZ LEITE, UFMG; SIMONE ODÍLIA ANTUNES FERNANDES, UFMG; VALBERT NASCIMENTO CARDOSO, UFMG.
Título: | Conjugated linoleic acid prevents damage caused by intestinal mucositis induced by 5-fluorouracil in an experimental model.
Ano de publicação: | 2018
Fonte/Imprenta: | Biomedicine & Pharmacotherapy, v. 103, p. 1567-1576, 2018.
DOI: | 10.1016/j.biopha.2018.04.133
Idioma: | Inglês
Conteúdo: | Abstract BACKGROUND: Studies have showed the protective effects of conjugated linoleic acid (CLA) on intestinal epithelium, modulating host immune and inflammatory responses on intestinal diseases. OBJECTIVE: To evaluate the preventive effects of CLA on the intestinal mucositis induced by 5-FU in a murine model. METHODS: Sixty-four BALB/c mice were randomly divided into four groups: Control (CTL), fed a standard chow diet; CLAs, fed a diet supplemented with CLA; Mucositis (5-FU), fed a standard chow diet and underwent mucositis induction and CLAs 5-FU, fed a diet supplemented with CLA and underwent mucositis induction. Mucositis was induced by intraperitoneal injection of 300&#8239;mg/kg 5-FU. After 72&#8239;h, the animals were euthanized and intestinal permeability, bacterial translocation, inflammatory mediators, and intestinal histology were evaluated. RESULTS: Mice in the CLAs 5-FU group showed reduced weight loss compared to those in the 5-FU group (p&#8239;<&#8239;0.005). Furthermore, the results also showed that the treatment with CLA reduced intestinal permeability, bacterial translocation, and biomarkers of inflammatory response besides minor damage to ZO-1 and occludin with maintenance of the integrity of the intestinal epithelium and a favorable balance between the inflammatory and regulatory cytokines. CONCLUSION: This study suggests that CLA reduced the adverse effects from 5-FU administration on the intestinal mucosa.
Palavras-Chave: | Bacterial translocation; Conjugated linoleic acids; Intestinal damage; Mucositis; Tight junction protein.
Thesaurus Nal: | Cytokines.
Categoria do assunto: | L Ciência Animal e Produtos de Origem Animal
Registro original: | Embrapa Gado de Leite (CNPGL)
Exemplares: | CNPGL - (24284-1) - UPC - AP - DD -  -  -  - DIS