Data/hora: 15/06/2024 11:52:05

Biblioteca(s): | Embrapa Unidades Centrais.
Data corrente: | 01/04/2016
Data da última atualização: | 29/12/2017
Autoria: | LIMA, L. R. de; MENDES, H. M. F.; SORIANI, F. M.; SOUZA, D. G. de; ALVES, G. E. S.; TEIXEIRA, M. M.; FALEIROS, R. R.
Afiliação: | LEONARDO R. DE LIMA, UFMG; HELOISA M. F. MENDES, UFMG; FREDERICO M. SORIANI, IBC/UFMG; DANIELLE G. DE SOUZA, ICB/UFMG; GERALDO ELENO S. ALVES, UFMG; MAURO M. TEIXEIRA, ICB/UFMG; RAFAEL R. FALEIROS, UFMG.
Título: | Histologic and inflammatory lamellar changes in horses with oligofructose-induced laminitis treated with a CXCR1/2 antagnist.
Ano de publicação: | 2016
Fonte/Imprenta: | Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 36, n. 1, p. 13-18, jan. 2016.
Idioma: | Inglês
Conteúdo: | With the hypothesis that blocking chemokine signaling can ameliorate acute laminitis, the aim was to evaluate the therapeutic effect of intravenous DF1681B, a selective antagonist for CXCR1 and CXCR2 (chemokine receptors), in an oligofructose equine laminitis model. To twelve mixed breed clinically healthy hoses with no previous history of hoof-related lameness was administered oligofructose (10g/kg given by nasogastric tube) and divided into two groups: treated (intravenous DF1681B at 30mg/kg 6, 12, 18, and 24h after oligofructose) and non-treated groups. Laminar biopsies were performed before and 12, 36, and 72h after administering oligofructose. Samples were stained with periodic acid-Schiff (PAS) and scored from 0 to 6 according to epidermal cell and basal membrane changes. The IL-1&#946;, IL-6, and CXCL1 RNA expressions were determined by RT-PCR. Parametric and non-parametric tests were used to compare times within each group (P<0.05). The PAS grades and IL-1&#946; and IL-6 RNA expression increased in the non-treated group, but remained constant in the treated horses. In conclusion, DF1681B therapy reduced laminar inflammation and epidermal deterioration in treated horses. CXCR1/2 blockage should be considered therapeutically for equine acute laminitis.
Palavras-Chave: | CXC receptors; Laminite; Neutrófilo; Quimiocina; Receptores CXC.
Thesaurus Nal: | Chemokines; Horses; Laminitis; Neutrophils.
Categoria do assunto: | --
URL: | http://ainfo.cnptia.embrapa.br/digital/bitstream/item/141897/1/Histologic-and-inflamatory-lamellar.pdf
Registro original: | Embrapa Unidades Centrais (AI-SEDE)
Exemplares: | AI-SEDE - (59250-1) - UPE - AP - PP - 636.08905 - P474 -  - DIS