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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sul; Embrapa Pesca e Aquicultura. |
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Data corrente: |
16/02/2016 |
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Data da última atualização: |
16/02/2016 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
BENAVIDES, M. V.; SONSTEGARD, T. S.; KEMP, S.; MUGAMBI, J. M.; GIBSON, J. P.; BAKER, R. L.; HANOTTE, O.; MARSHALL, K.; VAN TASSELL, C. |
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Afiliação: |
MAGDA VIEIRA BENAVIDES, CNPASA; TAD S. SONSTEGARD, USDA; STEPHEN KEMP, ILRI; JOHN M. MUGAMBI, KENYA AGRICULTURAL RESEARCH INSTITUTE; JOHN P. GIBSON, UNIVERSITY OF NEW ENGLAND; ROBERT LEYDEN BAKER, WAIKATO, NEW ZEALAND; OLIVIER HANOTTE, UNIVERSITY OF NOTTINGHAM; KAREN MARSHALL, ILRI; CURTIS VAN TASSELL, USDA. |
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Título: |
Identification of novel loci associated with gastrointestinal parasite resistance in a Red Maasai x Dorper backcross population. |
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Ano de publicação: |
2015 |
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Fonte/Imprenta: |
Plos One, v. 10, n. 4, e0122797, Apr. 2015. |
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DOI: |
10.1371/journal.pone.0122797 |
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Idioma: |
Inglês |
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Conteúdo: |
Gastrointestinal (GI) parasitic infection is the main health constraint for small ruminant production, causing loss of weight and/or death. Red Maasai sheep have adapted to a tropical environment where extreme parasite exposure is a constant, especially with highly pathogenic Haemonchus contortus. This breed has been reported to be resistant to gastrointestinal parasite infection, hence it is considered an invaluable resource to study associations between host genetics and resistance. The aim of this study was to identify polymorphisms strongly associated with host resistance in a double backcross population derived from Red Maasai and Dorper sheep using a SNP-based GWAS analysis. The animals that were genotyped represented the most resistant and susceptible individuals based on the tails of phenotypic distribution (10% each) for average faecal egg counts (AVFEC). AVFEC, packed cell volume (AVPCV), and live weight (AVLWT) were adjusted for fixed effects and co-variables, and an association analysis was run using EMMAX. Revised significance levels were calculated using 100,000 permutation tests. The top five significant SNP markers with - log10 p-values >3.794 were observed on five different chromosomes for AVFEC, and BLUPPf90/PostGSf90 results confirmed EMMAX significant regions for this trait. One of these regions included a cluster of significant SNP on chromosome (Chr) 6 not in linkage disequilibrium to each other. This genomic location contains annotated genes involved in cytokine signalling, haemostasis and mucus biosynthesis. Only one association detected on Chr 7 was significant for both AVPCV and AVLWT. The results generated here reveal candidate immune variants for genes involved in differential response to infection and provide additional SNP marker information that has potential to aid selection of resistance to gastrointestinal parasites in sheep of a similar genetic background to the double backcross population. MenosGastrointestinal (GI) parasitic infection is the main health constraint for small ruminant production, causing loss of weight and/or death. Red Maasai sheep have adapted to a tropical environment where extreme parasite exposure is a constant, especially with highly pathogenic Haemonchus contortus. This breed has been reported to be resistant to gastrointestinal parasite infection, hence it is considered an invaluable resource to study associations between host genetics and resistance. The aim of this study was to identify polymorphisms strongly associated with host resistance in a double backcross population derived from Red Maasai and Dorper sheep using a SNP-based GWAS analysis. The animals that were genotyped represented the most resistant and susceptible individuals based on the tails of phenotypic distribution (10% each) for average faecal egg counts (AVFEC). AVFEC, packed cell volume (AVPCV), and live weight (AVLWT) were adjusted for fixed effects and co-variables, and an association analysis was run using EMMAX. Revised significance levels were calculated using 100,000 permutation tests. The top five significant SNP markers with - log10 p-values >3.794 were observed on five different chromosomes for AVFEC, and BLUPPf90/PostGSf90 results confirmed EMMAX significant regions for this trait. One of these regions included a cluster of significant SNP on chromosome (Chr) 6 not in linkage disequilibrium to each other. This genomic location contains annotated genes involved i... Mostrar Tudo |
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Thesagro: |
Doença animal; Haemonchus Contortus; Nematoide; Ovelha. |
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Thesaurus Nal: |
Digestive system diseases; Sheep. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/139121/1/CNPASA-mvb.pdf
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Marc: |
LEADER 02850naa a2200301 a 4500
001 2037157
005 2016-02-16
008 2015 bl uuuu u00u1 u #d
024 7 $a10.1371/journal.pone.0122797$2DOI
100 1 $aBENAVIDES, M. V.
245 $aIdentification of novel loci associated with gastrointestinal parasite resistance in a Red Maasai x Dorper backcross population.$h[electronic resource]
260 $c2015
520 $aGastrointestinal (GI) parasitic infection is the main health constraint for small ruminant production, causing loss of weight and/or death. Red Maasai sheep have adapted to a tropical environment where extreme parasite exposure is a constant, especially with highly pathogenic Haemonchus contortus. This breed has been reported to be resistant to gastrointestinal parasite infection, hence it is considered an invaluable resource to study associations between host genetics and resistance. The aim of this study was to identify polymorphisms strongly associated with host resistance in a double backcross population derived from Red Maasai and Dorper sheep using a SNP-based GWAS analysis. The animals that were genotyped represented the most resistant and susceptible individuals based on the tails of phenotypic distribution (10% each) for average faecal egg counts (AVFEC). AVFEC, packed cell volume (AVPCV), and live weight (AVLWT) were adjusted for fixed effects and co-variables, and an association analysis was run using EMMAX. Revised significance levels were calculated using 100,000 permutation tests. The top five significant SNP markers with - log10 p-values >3.794 were observed on five different chromosomes for AVFEC, and BLUPPf90/PostGSf90 results confirmed EMMAX significant regions for this trait. One of these regions included a cluster of significant SNP on chromosome (Chr) 6 not in linkage disequilibrium to each other. This genomic location contains annotated genes involved in cytokine signalling, haemostasis and mucus biosynthesis. Only one association detected on Chr 7 was significant for both AVPCV and AVLWT. The results generated here reveal candidate immune variants for genes involved in differential response to infection and provide additional SNP marker information that has potential to aid selection of resistance to gastrointestinal parasites in sheep of a similar genetic background to the double backcross population.
650 $aDigestive system diseases
650 $aSheep
650 $aDoença animal
650 $aHaemonchus Contortus
650 $aNematoide
650 $aOvelha
700 1 $aSONSTEGARD, T. S.
700 1 $aKEMP, S.
700 1 $aMUGAMBI, J. M.
700 1 $aGIBSON, J. P.
700 1 $aBAKER, R. L.
700 1 $aHANOTTE, O.
700 1 $aMARSHALL, K.
700 1 $aVAN TASSELL, C.
773 $tPlos One$gv. 10, n. 4, e0122797, Apr. 2015.
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Registro original: |
Embrapa Pesca e Aquicultura (CNPASA) |
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Biblioteca |
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Tipo/Formato |
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| Registros recuperados : 55 | |
| 4. |  | SILVA, M. V. G. B.; TASSELL, C. P. V.; SONSTEGARD, T. S.; MATUKUMALLI, L.; SCHROEDER, S.; VANRADEN, P.; WIGGANS, G. Predição do valor genético total de touros da raça Holandesa por meio de mapas densos de marcadores. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA. 45., 2008, Lavras, MG. Anais... Viçosa, MG: Sociedade Brasileira de Zootecnia, 2008.| Tipo: Artigo em Anais de Congresso / Nota Técnica |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 6. | | BENAVIDES, M. V.; ECHEVARRIA, F. A. M.; SONSTEGARD, T. S.; VAN TESSEL, C. P.; GASBARRE, L. C. Genetic variability of a Bos taurus x Bos indicus cross population and validation of genomic regions influencing nematode resistance. In: SIMPOSIO DE RECURSOS GENETICOS PARA AMERICA LATINA Y EL CARIBE, 5., 2005, Montevideo, Uruguay. Resumenes... Montevideo: INIA :Facultad de Agronomía de la Universidad de la República, 2005. p. 105 SIRGEALC. Resumo 305.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sul. |
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| 9. | | LIU, G. E.; LI, R. W.; SONSTEGARD, T. S.; MATUKUMALLI, L. K.; SILVA, M. V. G. B.; VAN TASSELL, C. P. Characterization of a novel microdeletion polymorphism on BTA5 in cattle. Animal Genetics, v. 39, n. 6, p. 655-658, 2008.| Tipo: Artigo em Anais de Congresso / Nota Técnica |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 10. | | O'BRIEN, A. M. P.; MÉSZÁROS, G.; UTSUNOMIYA, Y. T.; SONSTEGARD, T. S.; GARCIA, J. F.; TASSEL, C. P. V.; CARVALHEIRO, R.; SILVA, M. V. G. B.; SÖLKNER, J. Linkage disequilibrium levels in Bos indicus and Bos taurus cattle using medium and high density SNP chip data and different minor allele frequency distributions. Livestock Science, v. 166, p. 121-132, 2014.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 11. | | GARCIA, J. F.; CARMO, A. S. DO; UTSUNOMIYA, Y. T.; NEVES, H. H. DE R.; CARVALHEIRO, R.; TASSELL, C. V.; SONSTEGARD, T. S.; SILVA, M. V. G. B. How bioinformatics enables livestock applied sciences in the genomic era. In: BRAZILIAN SYMPOSIUM ON BIOINFORMATICS, 2012, Heidelberg. Proceedings... Porto Alegre: Sociedade Brasileira e Computação, 2012.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 12. | | VENERONI, G. B.; MEIRELLES, S. L.; SANTIAGO, A. C.; SONSTEGARD, T. S.; OLIVEIRA, H. N.; YAMAGISHI, M. E. B.; ALENCAR, M. M. de; REGITANO, L. C. de A. Identification of genomic regions associated with backfat thickness in synthetic cattle. In: WORKSHOP DA REDE GENÔMICA ANIMAL, 1., 2009, Fortaleza. Anais... Fortaleza, Rede Genômica Animal, 2009.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 13. | | BENAVIDES, M. V.; SONSTEGARD, T. S.; KEMP, S.; MUGAMBI, J. M.; GIBSON, J. P.; BAKER, R. L.; HANOTTE, O.; MARSHALL, K.; VAN TASSELL, C. Identification of novel loci associated with gastrointestinal parasite resistance in a Red Maasai x Dorper backcross population. Plos One, v. 10, n. 4, e0122797, Apr. 2015.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Pecuária Sul; Embrapa Pesca e Aquicultura. |
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| 14. | | ANDREOTE, A. P. D.; ROSÁRIO, M. F. do; LEDUR, M. C.; JORGE, E. C.; SONSTEGARD, T. S.; MATUKUMALLI, L.; COUTINHO, L. L. Identification and characterization of microRNAs expressed in chicken skeletal muscle. Genetics and Molecular Research, v. 6, n. 1, p. 1465-1479, 2014.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 15. | | PORTO NETO, L. R.; SONSTEGARD, T. S.; LIU, G.; BICKHART, D.; GONDRO, C.; SILVA, M. V. G. B.; UTSUNOMIYA, Y. T.; GARCIA, J. F.; VAN TASSELL, C. P. Genomic divergence of indicine and taurine cattle identified through high-density SNP gebotyping. In: ADSA-ASAS ANNUAL MEETINGS, 2013, Indianápolis, Indiana. Abstracts... Indianápolis: [s.n.], 2013.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 16. | | O'BRIEN, A. M. P.; UTSUNOMIYA, Y. T.; MÉSZÁROS, G.; BICKHART, D. M.; LIU, G. E.; TASSEL, C. P. V.; SONSTEGARD, T. S.; SILVA, M. V. G. B.; GARCIA, J. F.; SÖLKNER, J. Assessing signatures of selection through variation in linkage disequilibrium between taurine and indicine cattle. Genetics Selection Evolution, v. 46, n. 19, 2014. 14 p.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 4 |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 17. | | VENERONI, G. B.; MEIRELLES, S. L.; SANTIAGO, A. G.; GROSSI, D. C.; SONSTEGARD, T. S.; YAMAGISHI, M. E. B.; COUTINHO, L. L.; OLIVEIRA, H. N.; ALENCAR, M. M. de; REGITANO, L. C. de A. Identification of genomic regions associated with backfat thickness in synthetic cattle. In: INTERNATIONAL CONFERENCE ON ANIMAL GENETICS, 32., 2010, Edinburgh. Proceedings... Edinburgh: International Society for Animal Genetics, 2010. P4020.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 18. | | VERONESI, G. B.; MEIRELLES, S. L.; SANTIAGO, A. C.; GROSSI, D. A.; SONSTEGARD, T. S.; YAMAGISHI, M. E. B.; COUTINHO, L. L.; OLIVEIRA, H. N.; ALENCAR, M. M.; REGITANO, L. C. de A. Identification of genomic regions associated with backfat thickness in synthetic cattle. In: INTERNATIONAL CONFERENCE ON ANIMAL GENETICS, 32., 2010, Edinburgh. Proceedings... Edinburgh: International Society for Animal Genetics, 2010. P4020.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital. |
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| 19. | | MIYATA, M.; GASPARIN, G.; COUTINHO, L. L.; MARTINEZ. M. L.; MACHADO, M. A.; SILVA, M. V. G. B.; CAMPOS, A. L.; SONSTEGARD, T. S.; REGITANO, L. C. de A. Caracterização genética de uma população experimental F2 usando marcadores moleculares no cromossomo 14 ( BTA 14) de bovinos. In: CONGRESSO BRASILEIRO DE GENÉTICA , 51., 2005, Águas de Lindóia. Lindóia: SBG, 2005. p. 364| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 20. | | MIYATA, M.; GASPARIN, G.; COUTINHO, L. L.; MARTINEZ, M. L.; MACHADO, M. A.; SILVA, M. V. G. B. da; CAMPOS, A. L.; SONSTEGARD, T. S.; ROSÁRIO, M. F. do; REGITANO, L. C. de A. Quantitative trait loci (QTL) mapping for growth traits on bovine chromosome 14. Genetics and Molecular Biology, Ribeirão Preto, v. 30, n. 2, p. 364-369, 2007.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: Internacional - A |
| Biblioteca(s): Embrapa Gado de Leite; Embrapa Pecuária Sudeste. |
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| Registros recuperados : 55 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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