Registro Completo |
Biblioteca(s): |
Embrapa Amazônia Ocidental. |
Data corrente: |
14/12/2023 |
Data da última atualização: |
15/12/2023 |
Tipo da produção científica: |
Resumo em Anais de Congresso |
Autoria: |
BASSICHETO, M.; OLIVEIRA, C.; RIVERO, M.; SIPOLONI, V.; SOARES, J. K. C.; SILVA, G. F. da; JUSTO, G.; VEIGA, T.; SOMAN, L. |
Afiliação: |
MILENA BASSICHETO, UNIVERSIDADE FEDERAL DE SÃO PAULO; CLÁUDIA OLIVEIRA, UNIVERSIDADE FEDERAL DE SÃO PAULO; MILENA RIVERO, UNIVERSIDADE FEDERAL DE SÃO PAULO; VICTOR SIPOLONI, UNIVERSIDADE FEDERAL DE SÃO PAULO; JULLIO KENNEDY CASTRO SOARES, UNIVERSIDADE FEDERAL DE SÃO PAULO; GILVAN FERREIRA DA SILVA, CPAA; GISELLE JUSTO, UNIVERSIDADE FEDERAL DE SÃO PAULO; THIAGO VEIGA, UNIVERSIDADE FEDERAL DE SÃO PAULO; LÍVIA SOMAN, UNIVERSIDADE FEDERAL DE SÃO PAULO. |
Título: |
Detection of antileukemia metabolites from P. limosum integrating genome mining, metabolomic analysis and cytotoxicity assays. |
Ano de publicação: |
2023 |
Fonte/Imprenta: |
In: BRAZILIAN CONFERENCE ON NATURAL PRODUCT (BCNP), 9.; MEETING ON MICROMOLECULAR EVOLUTION, SYSTEMATICS AND ECOLOGY (RESEM), 35., 2023, Salvador. Proceedings [...] Campinas: Galoá, 2023. |
Idioma: |
Inglês |
Conteúdo: |
Chemical dereplication and genome mining approaches were applied to detect cytotoxic metabolites produced by P. limosum CMLD 19 with anticancer potential against human leukemia cells. During the ongoing study, metabolites such as fumitremorgin and triprostatin were detected in the rice extract of P. limosum which showed 80% of cell inhibition for different human leukemia cell lines. |
Palavras-Chave: |
Chemical dereplication; Cytotoxic metabolites. |
Thesaurus Nal: |
Genome mining; Leukemia. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1159736/1/galoa-proceedings-bcnp-2023-173097.pdf
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Marc: |
LEADER 01285nam a2200253 a 4500 001 2159736 005 2023-12-15 008 2023 bl uuuu u00u1 u #d 100 1 $aBASSICHETO, M. 245 $aDetection of antileukemia metabolites from P. limosum integrating genome mining, metabolomic analysis and cytotoxicity assays.$h[electronic resource] 260 $aIn: BRAZILIAN CONFERENCE ON NATURAL PRODUCT (BCNP), 9.; MEETING ON MICROMOLECULAR EVOLUTION, SYSTEMATICS AND ECOLOGY (RESEM), 35., 2023, Salvador. Proceedings [...] Campinas: Galoá$c2023 520 $aChemical dereplication and genome mining approaches were applied to detect cytotoxic metabolites produced by P. limosum CMLD 19 with anticancer potential against human leukemia cells. During the ongoing study, metabolites such as fumitremorgin and triprostatin were detected in the rice extract of P. limosum which showed 80% of cell inhibition for different human leukemia cell lines. 650 $aGenome mining 650 $aLeukemia 653 $aChemical dereplication 653 $aCytotoxic metabolites 700 1 $aOLIVEIRA, C. 700 1 $aRIVERO, M. 700 1 $aSIPOLONI, V. 700 1 $aSOARES, J. K. C. 700 1 $aSILVA, G. F. da 700 1 $aJUSTO, G. 700 1 $aVEIGA, T. 700 1 $aSOMAN, L.
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Registro original: |
Embrapa Amazônia Ocidental (CPAA) |
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