Data/hora: 17/06/2024 11:54:24

Biblioteca(s): | Embrapa Pecuária Sul.
Data corrente: | 10/09/2021
Data da última atualização: | 10/09/2021
Autoria: | BENAVIDES, M. V.; SOUZA, C. J. H. de; SMITH, W. D.; MORAES, J. C. F.
Afiliação: | MAGDA VIEIRA BENAVIDES, CPPSUL; CARLOS JOSE HOFF DE SOUZA, CPPSUL; W. DAVID SMITH, Moredun Research Institute; JOSE CARLOS FERRUGEM MORAES, CPPSUL.
Título: | Evaluation of protection in grazing lambs immunised with different doses of Haemonchus contortus gut membrane glycoproteins in Southern Brazil.
Ano de publicação: | 2021
Fonte/Imprenta: | Veterinary Parasitology, v. 290, 109360, Feb. 2021.
Idioma: | Inglês
Conteúdo: | A vaccine containing doses ranging from 2 &#956;g to 50 &#956;g of integral membrane proteins from Haemonchus contortus intestinal cells (H11 and H-gal-GP complex) has been shown to be effective for lambs. A vaccine for H. contortus was tested in two-month old grazing Corriedale lambs during an eight-month trial on the outskirts of Bagé, Rio Grande do Sul, Brazil. The animals were kept in a single paddock and allocated to five similar groups according to weight, sex and faecal egg counts (FEC). Vaccinated lambs received 0, 2, 5, 10 or 50 &#956;g of the same antigen diluted in QuilA adjuvant. Vaccine injections were given at days 0, 21, 49, 91, 133, and 175. Lambs were sampled weekly for FEC, packed cell volume (PCV), and plasma ELISA antibody titre. Lambs with PCVs &#8804;15 % were drenched with levamisole (7.5 mg/kg body weight) as a salvage treatment. During days 77?98 an artificial challenge was administered to increase parasite transmission. Post-artificial challenge (from day 98?217), the FEC of the vaccinated lambs were 59.3 % lower than those of the control lambs. Antigen dose correlated with changes in PCV (r = 0.387 p-value < 0.001). Vaccinated lambs also had higher PCV than controls (p < 0.001; contrast analysis). Salvage treatment was needed in 16.7 % of vaccinated lambs and 88 % of control lambs.
Thesagro: | Antígeno; Cordeiro; Haemonchus Contortus; Vacina.
Categoria do assunto: | --
Registro original: | Embrapa Pecuária Sul (CPPSUL)
Exemplares: | CPPSUL - (14815-1) - UPC - AP - DD -  -  -  - DIS