Data/hora: 24/06/2024 12:20:37

Biblioteca(s): | Ebooks.
Data corrente: | 01/02/2013
Data da última atualização: | 01/02/2013
Autoria: | SIMON, M. C.
Afiliação: | M. Celeste Simon.
Título: | Diverse Effects of Hypoxia on Tumor Progression.
Ano de publicação: | 2010
Fonte/Imprenta: | Springer eBooks.
Volume: | 345
Páginas: | X, 146 p.
Descrição Física: | digital.
Série: | Current Topics in Microbiology and Immunology,
ISBN: | 9783642133299
DOI: | 10.1007/978-3-642-13329-9
Idioma: | Inglês
Conteúdo: | Solid tumors frequently contain areas of oxygen deprivation (hypoxia) due to rapid cell proliferation and/or vascular insufficiency. The presence of hypoxic domains typically correlates with poor patient prognosis, due to the relative resistance of hypoxic cells to conventional cancer therapies and effects of O2 availability on disease progression. The response of malignant cells to hypoxia has been the focus of intense research over the last decade. In this issue of Current Topics in Microbiology and Immunology, the authors present articles describing the impact of hypoxia on components of the tumor microenvironment (such as endothelial cells, inflammatory cells, and tumor associated fibroblasts), the expression of unique microRNAs, tumor cell differentiation status, and metastasis. Each review article describes the state of the field studying these topics, and poses important questions for the future. The overall goal is to depict tumor phenotypes and associated molecular pathways to be exploited in the development of novel therapeutics to be used against a broad spectrum of human cancers.
Palavras-Chave: | Biomedicine; Cancer Research; Oncology.
Thesaurus Nal: | embryology; human physiology; medicine.
Categoria do assunto: | --
URL: | http://dx.doi.org/10.1007/978-3-642-13329-9
Registro original: | Ebooks (Ebooks)