Data/hora: 23/09/2024 19:33:50

Biblioteca(s): 	Embrapa Agroindústria Tropical; Embrapa Mandioca e Fruticultura.	
Data corrente: 	17/09/2018	
Data da última atualização: 	17/10/2019	
Autoria: 	GUEDES, J. A. C.; ALVES FILHO, E. G.; RODRIGUES, T. H. S.; SILVA, M. F. S.; SOUZA, F. V. D.; SILVA, L. M. A. e; ALVES, R. E.; CANUTO, K. M.; BRITO, E. S. de; PESSOA, C. O.; NASCIMENTO, R. F.; ZOCOLO, G. J.	
Afiliação: 	Jhonyson Arruda Carvalho Guedes, Universidade Federal do Ceará; Elenilson de Godoy Alves Filho, Embrapa Agroindústria Tropical, bolsista; TIGRESSA HELENA SOARES RODRIGUES, CNPAT; Maria Francilene Souza Silva, Universidade Federal do Ceará; FERNANDA VIDIGAL DUARTE SOUZA, CNPMF; LORENA MARA ALEXANDRE E SILVA, CNPAT; RICARDO ELESBAO ALVES, CNPAT; KIRLEY MARQUES CANUTO, CNPAT; EDY SOUSA DE BRITO, CNPAT; Cláudia do Ó Pessoa, Universidade Federal do Ceará; Ronaldo Ferreira Nascimento, Universidade Federal do Ceará; GUILHERME JULIAO ZOCOLO, CNPAT.	
Título: 	Metabolic profile and cytotoxicity of non-polar extracts of pineapple leaves and chemometric analysis of different pineapple cultivars.	
Ano de publicação: 	2018	
Fonte/Imprenta: 	Industrial Crops and Products, v. 124, p. 466-474, 2018.	
Idioma: 	Inglês	
Conteúdo: 	The use of co-products from the fruit agroindustry as a source of bioactive molecules presents economic advantages, since these compounds are highly available and inexpensive. Therefore, the present study aimed to evaluate their qualitative chemical composition followed by multivariate analysis, and to correlate the results with those of the cytotoxicity tests. The non-polar metabolic profiles of the leaves of seven commercial pineapple (Ananas comosus (L.) Merr.) cultivars were investigated by using GC?MS. Twenty-seven metabolites were identified from the seven hexanic extracts. Multivariate analysis (Hierarchical Cluster Analysis, Principal Component Analysis and Partial Least Squares) revealed significant differences in the metabolic fingerprint of the different cultivars. Overall, the hexanic extracts of the seven cultivars of pineapple leaves showed promising antitumor activity against the six tumor lines tested (colon, leukemia, prostate, astrocytoma, breast and cervix). Correlation of the chemometric data, qualitative analysis, and cytotoxic tests allowed us to determine the possible biomarkers responsible for each specific antitumor activity. This study demonstrates a great valuation potential of a co-product little explored in the agroindustry of foods through the prospection of biologically active compounds.	
Palavras-Chave: 	GC MS.	
Thesagro: 	Abacaxi.	
Thesaurus Nal: 	Ananas; Cytotoxicity; Multivariate analysis.	
Categoria do assunto: 	--	
Registro original: 	Embrapa Agroindústria Tropical (CNPAT)	
Exemplares: 	CNPAT - (15680-1) - UPC - AP - DD -  -  - 2018.0231 - DIS
CNPMF - (32510-1) - UPC - AP - DD - Publicação digital -  -  - DIS