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Registro Completo |
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Biblioteca(s): |
Embrapa Clima Temperado. |
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Data corrente: |
03/12/2020 |
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Data da última atualização: |
03/12/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SILVA, D. T. da; RODRIGUES, R. F.; MACHADO, N. M.; MAURER, L. H.; FERREIRA, L. F.; SOMACAL, S.; VEIGA, M. L. da; ROCHA, M. I. de U. M. da; VIZZOTTO, M.; RODRIGUES, E.; BARCIA, M. T.; EMANUELLI, T. |
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Afiliação: |
DARIANE TRIVISIOL DA SILVA, UFSM; RENATA FRITZSCHE RODRIGUES, UFSM; NATALIA MINUZZI MACHADO, UFSM; LUANA HASELEIN MAURER, INSTITUTO FEDERAL FARROUPILHA; LAUREN FRESINGHELLI FERREIRA, UFSM; SABRINA SOMACAL, UFSM; MARCELO LEITE DA VEIGA, UFSM; MARIA IZABEL DE UGALDE MARQUES DA ROCHA, UFSM; MARCIA VIZZOTTO, CPACT; ELISEU RODRIGUES, UFRGS; MILENE TEIXEIRA BARCIA, UFSM; TATIANA EMANUELLI, UFSM. |
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Título: |
Natural deep eutectic solvent (NADES)-based blueberry extracts protect against ethanol-induced gastric ulcer in rats. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
Food Research International , v. 138, Part A, 109718, Dec. 2020. |
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ISSN: |
0963-9969 |
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DOI: |
doi.org/10.1016/j.foodres.2020.109718 |
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Idioma: |
Inglês |
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Conteúdo: |
Blueberry is a polyphenol-rich fruit bearing great bioactive potential. Natural deep eutectic solvents (NADES) emerged as putatively biocompatible solvents that could substitute for toxic organic solvents in the extraction of fruit phenolic compounds for developing nutraceuticals or functional foods. Therefore, the aim of this study was to investigate the gastroprotective effects and the biocompatibility of a blueberry crude extract (CE) obtained using NADES and of the extract fractions (anthocyanin-rich fraction ? ARF; non-anthocyanin phenolic fraction - NAPF) in a model of ethanol-induced gastric ulcer in rats. CE was the NADES-containing, ready-to-use extract that was obtained using choline chloride:glycerol:citric acid NADES (0.5:2:0.5 M ratio). ARF and NAPF were the NADES-free fractions obtained by solid phase purification of CE and were investigated to identify the bioactive fraction responsible for the effects of CE. Animals were treated for 14 days with water, NADES vehicle, CE, ARF, NAPF or lansoprazole (intragastric) and then received ethanol to induce gastric ulcer. CE decreased ulcer index and preserved the integrity of gastric mucosa. The pretreatment with CE or ARF reduced glutathione depletion and the inflammatory response. All treatments, including NADES vehicle reduced protein oxidation and nitric oxide overproduction in ethanol-treated rats. Additionally, ARF increased short-chain fatty acids in feces. These findings suggest that NADES can be used to obtain biocompatible extracts of blueberry that exhibit gastroprotective effects with no need of solvent removal. The gastroprotective effects were mainly associated to ARF but NAPF and even NADES vehicle also contributed to some protective effects. MenosBlueberry is a polyphenol-rich fruit bearing great bioactive potential. Natural deep eutectic solvents (NADES) emerged as putatively biocompatible solvents that could substitute for toxic organic solvents in the extraction of fruit phenolic compounds for developing nutraceuticals or functional foods. Therefore, the aim of this study was to investigate the gastroprotective effects and the biocompatibility of a blueberry crude extract (CE) obtained using NADES and of the extract fractions (anthocyanin-rich fraction ? ARF; non-anthocyanin phenolic fraction - NAPF) in a model of ethanol-induced gastric ulcer in rats. CE was the NADES-containing, ready-to-use extract that was obtained using choline chloride:glycerol:citric acid NADES (0.5:2:0.5 M ratio). ARF and NAPF were the NADES-free fractions obtained by solid phase purification of CE and were investigated to identify the bioactive fraction responsible for the effects of CE. Animals were treated for 14 days with water, NADES vehicle, CE, ARF, NAPF or lansoprazole (intragastric) and then received ethanol to induce gastric ulcer. CE decreased ulcer index and preserved the integrity of gastric mucosa. The pretreatment with CE or ARF reduced glutathione depletion and the inflammatory response. All treatments, including NADES vehicle reduced protein oxidation and nitric oxide overproduction in ethanol-treated rats. Additionally, ARF increased short-chain fatty acids in feces. These findings suggest that NADES can be used to obtain... Mostrar Tudo |
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Thesagro: |
Extrato; Mirtilo. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/218692/1/Natural-deep-eutectic-solvent.pdf
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Marc: |
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024 7 $adoi.org/10.1016/j.foodres.2020.109718$2DOI
100 1 $aSILVA, D. T. da
245 $aNatural deep eutectic solvent (NADES)-based blueberry extracts protect against ethanol-induced gastric ulcer in rats.$h[electronic resource]
260 $c2020
520 $aBlueberry is a polyphenol-rich fruit bearing great bioactive potential. Natural deep eutectic solvents (NADES) emerged as putatively biocompatible solvents that could substitute for toxic organic solvents in the extraction of fruit phenolic compounds for developing nutraceuticals or functional foods. Therefore, the aim of this study was to investigate the gastroprotective effects and the biocompatibility of a blueberry crude extract (CE) obtained using NADES and of the extract fractions (anthocyanin-rich fraction ? ARF; non-anthocyanin phenolic fraction - NAPF) in a model of ethanol-induced gastric ulcer in rats. CE was the NADES-containing, ready-to-use extract that was obtained using choline chloride:glycerol:citric acid NADES (0.5:2:0.5 M ratio). ARF and NAPF were the NADES-free fractions obtained by solid phase purification of CE and were investigated to identify the bioactive fraction responsible for the effects of CE. Animals were treated for 14 days with water, NADES vehicle, CE, ARF, NAPF or lansoprazole (intragastric) and then received ethanol to induce gastric ulcer. CE decreased ulcer index and preserved the integrity of gastric mucosa. The pretreatment with CE or ARF reduced glutathione depletion and the inflammatory response. All treatments, including NADES vehicle reduced protein oxidation and nitric oxide overproduction in ethanol-treated rats. Additionally, ARF increased short-chain fatty acids in feces. These findings suggest that NADES can be used to obtain biocompatible extracts of blueberry that exhibit gastroprotective effects with no need of solvent removal. The gastroprotective effects were mainly associated to ARF but NAPF and even NADES vehicle also contributed to some protective effects.
650 $aExtrato
650 $aMirtilo
700 1 $aRODRIGUES, R. F.
700 1 $aMACHADO, N. M.
700 1 $aMAURER, L. H.
700 1 $aFERREIRA, L. F.
700 1 $aSOMACAL, S.
700 1 $aVEIGA, M. L. da
700 1 $aROCHA, M. I. de U. M. da
700 1 $aVIZZOTTO, M.
700 1 $aRODRIGUES, E.
700 1 $aBARCIA, M. T.
700 1 $aEMANUELLI, T.
773 $tFood Research International$gv. 138, Part A, 109718, Dec. 2020.
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Registro original: |
Embrapa Clima Temperado (CPACT) |
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| Registros recuperados : 13 | |
| 1. |  | SILVA, D. T. da; MOURA, E. F.; FARIAS NETO, J. T. de; RAMALHO, G. F. Divergência genética entre acessos de macaxeira com mesma sinonímia no banco de germoplasma de mandioca da Embrapa Amazônia Oriental. In: SEMINÁRIO DE INICIAÇÃO CIENTÍFICA DA EMBRAPA, 14., 2010, Belém, PA. Bolsista de iniciação científica: um aporte ao desenvolvimento da pesquisa agropecuária: anais. Belém, PA: Embrapa Amazônia Oriental, 2010. 1 CD-ROM. PIBIC 2010.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 3. | | RAMALHO, G. F.; MOURA, E. F.; FARIAS NETO, J. T. de; SILVA, D. T. da. Diferenciação genética entre possíveis duplicatas no banco de germoplasma de mandioca da Embrapa Amazônia Oriental por meio de marcadores microssatélites. In: SEMINÁRIO DE INICIAÇÃO CIENTÍFICA DA EMBRAPA, 14., 2010, Belém, PA. Bolsista de iniciação científica: um aporte ao desenvolvimento da pesquisa agropecuária: anais. Belém, PA: Embrapa Amazônia Oriental, 2010. 1 CD-ROM. PIBIC 2010. PIBIC 2010.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 4. | | HASE, L. M.; SILVA, D. T. da; WISNIEWSKI, C.; NITTA, V.; SANTOS, C. A. de M. Utilização de quatro espécies arbóreas de uso medicinal no sistema faxinal da Comunidade dos Antônios im Irati - PR. In: CONGRESSO BRASILEIRO DE SISTEMAS AGROFLORESTAIS, 5., 2004, Curitiba. SAFs: desenvolvimento com proteção ambiental: anais. Colombo: Embrapa Florestas, 2004. p. 313-315. (Embrapa Florestas. Documentos, 98).| Biblioteca(s): Embrapa Florestas. |
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| 5. | | MOURA, E. F.; FARIAS NETO, J. T. de; SAMPAIO, J. E.; SILVA, D. T. da; RAMALHO, G. F. Identification of duplicates of cassava accessions sampled on the North Region of Brazil using microsatellite markers. Acta Amazonica, Manaus, v. 43, n. 4, p. 461-468, 2013.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 7. | | MOURA, E. F.; FARIAS NETO, J. T. de; RAMALHO, G. F.; SILVA, D. T. da; SAMPAIO, J. E. Duplicatas no Banco de Germoplasma de mandioca da Embrapa Amazônia Oriental detectadas por marcadores microssatélites. In: CONGRESSO BRASILEIRO DE MANDIOCA, 14.; FEIRA BRASILEIRA DA MANDIOCA, 1., 2011, Maceió. Mandioca: fonte de alimento e energia: anais. Maceió: ABAM: SBM, 2011. 1 CD-ROM.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 9. | | SILVA, D. T. da; SMANIOTTO, F. A.; COSTA, I. F.; BARANZELLI, J.; MULLER, A.; SOMACAL, S.; MONTEIRO, C. S.; VIZZOTTO, M.; RODRIGUES, E.; BARCIA, M. T.; EMANUELLI, T. Natural deep eutectic solvent (NADES): A strategy to improve the bioavailability of blueberry phenolic compounds in a ready-to-use extract. Food Chemistry, v. 364, 130370, Dec. 2021.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Clima Temperado. |
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| 10. | | BARANZELLI, J.; MONTEIRO, C. S.; SMANIOTTO, F. A.; DELALIBERA, E. A.; COSTA, I. F.; SILVA, D. T. da; SOMACAL, S.; MIRANDA, M. Z. de; EMANUELLI, T. Technological quality and phenolic compounds content of Embrapa wheat cultivars. In: SIMPÓSIO LATINO AMERICANO DE CIÊNCIA DE ALIMENTOS, 13., 2019, Campinas. Anais... Campinas: UNICAMP - FEA: Associação Latino Americana de Ciência dos Alimentos, 2019. v. 4, Eixo 2. Caracterização química e físico-química de alimentos (FQ), pôster 117047.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Trigo. |
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| 11. | | SILVA, M. L. da; CHAGAS, E. A.; FLORES, P. S.; SILVA, D. T. da; BARDALES, R. M. L.; PASQUAL, M.; COUCEIRO, M. A.; ARAÚJO, M. da C. da R. Alongamento e número de brotações de orquídeas cultivadas in vitro sob diferentes meios de cultura e concentrações. CONGRESSO BRASILEIRO DE FLORICULTURA E PLANTAS ORNAMENTAIS, 18.; CONGRESSO BRASILEIRO DE CULTURA DE TECIDOS DE PLANTAS, 5. 2011. Joinville - SC. [Anais...]. Joinville-SC: EPAGRI, 2011. 1 CD-ROM. 2 p.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Acre; Embrapa Roraima. |
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| 12. | | BARANZELLI, J.; SOMACAL, S.; BONINI, C. A. A.; SMANIOTTO, F. A.; MONTEIRO, C. S.; SILVA, D. T. da; MELLO, R. de O.; BOLDORI, J. R.; DENARDIN, C. C.; RODRIGUES, E.; MIRANDA, M. Z. de; EMANUELLI, T. Influence of sprouting on the bioaccessibility and bioactivity of benzoxazinoids, phenolic acids, and flavonoids of soft and hard wheat cultivars. Food Research International, v. 173, article 113338, 2023.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Trigo. |
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| 13. | | SILVA, D. T. da; RODRIGUES, R. F.; MACHADO, N. M.; MAURER, L. H.; FERREIRA, L. F.; SOMACAL, S.; VEIGA, M. L. da; ROCHA, M. I. de U. M. da; VIZZOTTO, M.; RODRIGUES, E.; BARCIA, M. T.; EMANUELLI, T. Natural deep eutectic solvent (NADES)-based blueberry extracts protect against ethanol-induced gastric ulcer in rats. Food Research International , v. 138, Part A, 109718, Dec. 2020.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Clima Temperado. |
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| Registros recuperados : 13 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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