| |
|
|
|
Registro Completo |
|
Biblioteca(s): |
Embrapa Unidades Centrais. |
|
Data corrente: |
29/11/2017 |
|
Data da última atualização: |
29/12/2017 |
|
Autoria: |
SOUZA, C. A.; SILVA, J. F.; SILVA, C. L. R.; OCARINO, N. M.; SERAKIDES, R. |
|
Afiliação: |
Cíntia A. Souza, Programa de Pós-Graduação em Ciência Animal, Departamento de Clínica e Cirurgia Veterinária-DCCV/Escola de Veterinária/Universidade Federal de Minas Gerais - UFMG; JUNEO F. SILVA, Setor de Morfologia/Departamento de Ciências Biológicas/Universidade Estadual de Santa Cruz; Camila L. R. Silva, Iniciação Científica/Setor de Patologia Animal - DCCV/Escola de Veterinária/UFMG; Natália M. Ocarino, Setor de Patologia Animal - DCCV/Escola de Veterinária/UFMG; Rogéria Serakides, Setor de Patologia Animal - DCCV/Escola de Veterinária/UFMG. |
|
Título: |
Thyroid hormones affect decidualization and angiogenesis in the decidua and metrial gland of rats. |
|
Ano de publicação: |
2017 |
|
Fonte/Imprenta: |
Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 37, n. 9, p. 1002-1014, setembro. 2017. |
|
Idioma: |
Inglês |
|
Notas: |
Título em português: Hormônios tireoidianos afetam a decidualização e a angiogênese na decídua e glândula metrial de ratas. |
|
Conteúdo: |
This study aimed to evaluate the effects of thyroid hormone on the decidua and metrial gland of rats and to examine the expression of angiogenic factors. 72 adult, female rats were divided into hypothyroid, T4-treated2, and control groups. At 10, 14 and 19 days of gestation (DG), the decidua and metrial gland were collected for histomorphometric and immunohistochemical evaluation of the expression of VEGF, Flk-1 and Tie-2. Hypothyroidism reduced the area of the decidua at 10 and 19 DG. Furthermore, VEGF was increased at 10 and 14 DG, and Flk-1 only at 14 DG, but both was reduced at 19 DG in the metrial gland without significantly changing the area occupied by blood vessels. Rats treated with T4 showed an increase in the decidua blood vessels at 10 and 19 DG. However, at 10 DG, excess T4 resulted in increased of Flk-1 in the decidua and metrial gland. Hypothyroidism increased the Tie-2 at 10 and 19 DG in the decidua and metrial gland. In conclusion, hypothyroidism reduces the area of the decidua and increases the expression of VEGF, Tie-2 and Flk-1. The excess of T4 promotes tissue angiogenesis by increasing the number of vessels in the decidua because of the increased expression of Flk-1. |
|
Palavras-Chave: |
Angiogênese; Decídua; Decidualização; Decidualization; Glândula metrial; Hormônio tireoidiano; Metrial gland; PTU; Rata. |
|
Thesagro: |
Tiroxina. |
|
Thesaurus Nal: |
Angiogenesis; Rats; Thyroid hormones; Thyroxine. |
|
Categoria do assunto: |
-- |
|
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/167764/1/Thyroid-hormones-affect-decidualization.pdf
|
|
Marc: |
LEADER 02309naa a2200349 a 4500
001 2081011
005 2017-12-29
008 2017 bl uuuu u00u1 u #d
100 1 $aSOUZA, C. A.
245 $aThyroid hormones affect decidualization and angiogenesis in the decidua and metrial gland of rats.$h[electronic resource]
260 $c2017
500 $aTítulo em português: Hormônios tireoidianos afetam a decidualização e a angiogênese na decídua e glândula metrial de ratas.
520 $aThis study aimed to evaluate the effects of thyroid hormone on the decidua and metrial gland of rats and to examine the expression of angiogenic factors. 72 adult, female rats were divided into hypothyroid, T4-treated2, and control groups. At 10, 14 and 19 days of gestation (DG), the decidua and metrial gland were collected for histomorphometric and immunohistochemical evaluation of the expression of VEGF, Flk-1 and Tie-2. Hypothyroidism reduced the area of the decidua at 10 and 19 DG. Furthermore, VEGF was increased at 10 and 14 DG, and Flk-1 only at 14 DG, but both was reduced at 19 DG in the metrial gland without significantly changing the area occupied by blood vessels. Rats treated with T4 showed an increase in the decidua blood vessels at 10 and 19 DG. However, at 10 DG, excess T4 resulted in increased of Flk-1 in the decidua and metrial gland. Hypothyroidism increased the Tie-2 at 10 and 19 DG in the decidua and metrial gland. In conclusion, hypothyroidism reduces the area of the decidua and increases the expression of VEGF, Tie-2 and Flk-1. The excess of T4 promotes tissue angiogenesis by increasing the number of vessels in the decidua because of the increased expression of Flk-1.
650 $aAngiogenesis
650 $aRats
650 $aThyroid hormones
650 $aThyroxine
650 $aTiroxina
653 $aAngiogênese
653 $aDecídua
653 $aDecidualização
653 $aDecidualization
653 $aGlândula metrial
653 $aHormônio tireoidiano
653 $aMetrial gland
653 $aPTU
653 $aRata
700 1 $aSILVA, J. F.
700 1 $aSILVA, C. L. R.
700 1 $aOCARINO, N. M.
700 1 $aSERAKIDES, R.
773 $tPesquisa Veterinária Brasileira, Rio de Janeiro$gv. 37, n. 9, p. 1002-1014, setembro. 2017.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Unidades Centrais (AI-SEDE) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
|
| Registros recuperados : 2 | |
| 1. |  | SOUZA, C. A.; SILVA, J. F.; SILVA, C. L. R.; OCARINO, N. M.; SERAKIDES, R. Thyroid hormones affect decidualization and angiogenesis in the decidua and metrial gland of rats. Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 37, n. 9, p. 1002-1014, setembro. 2017. Título em português: Hormônios tireoidianos afetam a decidualização e a angiogênese na decídua e glândula metrial de ratas.| Biblioteca(s): Embrapa Unidades Centrais. |
|    |
| 2. | | ALMEIDA, D. S.; SANTOS, A. C. dos; SILVA, C. L. R. da; ORIÁ, A. P.; OLIVEIRA, A. V. D.; LIBÓRIO, F. A.; ATHANAZIO, D. A.; PINNA, M. H. Evidence of leptospiral exposure in neotropical primates recued from illegal trade and a Zoo in Bahia, Brazil. Pesquisa Veterinária Brasileira, Brasília, DF, v. 39, n. 9, p. 864-868, set. 2016.| Biblioteca(s): Embrapa Unidades Centrais. |
| |
| Registros recuperados : 2 | |
|
| Nenhum registro encontrado para a expressão de busca informada. |
|
|
