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 | Acesso ao texto completo restrito à biblioteca da Embrapa Pecuária Sudeste. Para informações adicionais entre em contato com cppse.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
29/08/2023 |
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Data da última atualização: |
29/08/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
CHOCOBAR, M. L. E.; BELLO, H. J. S.; BASSETTO, C. C.; SILVA-MARINHO, N. M.; SATO, L. M. N.; SPERB, C.; CHAGAS, A. C. de S.; AMARANTE, A. F. T. |
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Afiliação: |
M. L. E. CHOCOBAR, São Paulo State University; H. J. S. BELLO, São Paulo State University; C. C. BASSETTO, São Paulo State University; N. M. SILVA-MARINHO, São Paulo State University; L. M. N. SATO, São Paulo State University; C. SPERB, São Paulo State University; ANA CAROLINA DE SOUZA CHAGAS, CPPSE; A. F. T. AMARANTE, São Paulo State University. |
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Título: |
Biotic potential and pathogenicity of a Haemonchus contortus susceptible laboratory isolate compared to a resistant field isolate in Brazil. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Small Ruminant Research, v. 227, oct. 2023, 107063. |
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Páginas: |
10 p. |
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DOI: |
https://doi.org/10.1016/j.smallrumres.2023.107063 |
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Idioma: |
Inglês |
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Conteúdo: |
The high prevalence of anthelmintic resistance of Haemonchus contortus is threatening sheep farming. In this context, resistant populations? replacement using susceptible isolates appears to be a strategy to overcome this situation. The aim of the present study was to evaluate the ability of a susceptible H. contortus laboratory isolate in comparison with a multiresistant field isolate to infect lambs and to study its behaviour in field conditions. Sixteen worm-free lambs were experimentally infected with 4000 infective larvae (L3) of a H. contortus anthelmintic-resistant field isolate (Group R, n = 8) or a laboratory isolate susceptible to anthelmintics (Group S, n = 8). Groups were placed in separate clean pastures, where they were kept for 266 days. Faecal egg counts (FEC) showed maximum values between 21- and 42-days post-infection (PI) and decreased over time, with no statistical differences between groups (P > 0.05). The pathogenicity of the isolates was similar, as lambs from both groups showed a decrease in packed cell volume and total plasma protein values in the beginning of the study, coinciding with the highest FECs. Production of L3 were similar for both groups, when evaluating faecal cultures kept in vitro or L3 recovered from pasture samples and from faecal pats collected from the paddocks, which suggests that both isolates have the same potential of development in vitro and in the environment. The degree of resistance/susceptibility to thiabendazole (TIA), levamisole (LEV), monepantel (MON) and ivermectin (IVE) was evaluated using the Larval Development Assay (RESISTA-Test©) 160 days PI. The resistant isolate showed a high resistance factor (RF) to TIA (141), LEV (822), MON (34) and IVE (196), while the RF of the susceptible isolate remained below three, which indicates high susceptibility to all drugs tested. Our study demonstrates that the susceptible isolate was able to infect lambs and did not show higher pathogenicity nor any differences on its biotic potential when compared to the resistant field isolate. These results indicate that the susceptible isolate has the potential to be used to replace a resistant population of H. contortus, which should be validated in long-term studies under commercial sheep farming conditions. MenosThe high prevalence of anthelmintic resistance of Haemonchus contortus is threatening sheep farming. In this context, resistant populations? replacement using susceptible isolates appears to be a strategy to overcome this situation. The aim of the present study was to evaluate the ability of a susceptible H. contortus laboratory isolate in comparison with a multiresistant field isolate to infect lambs and to study its behaviour in field conditions. Sixteen worm-free lambs were experimentally infected with 4000 infective larvae (L3) of a H. contortus anthelmintic-resistant field isolate (Group R, n = 8) or a laboratory isolate susceptible to anthelmintics (Group S, n = 8). Groups were placed in separate clean pastures, where they were kept for 266 days. Faecal egg counts (FEC) showed maximum values between 21- and 42-days post-infection (PI) and decreased over time, with no statistical differences between groups (P > 0.05). The pathogenicity of the isolates was similar, as lambs from both groups showed a decrease in packed cell volume and total plasma protein values in the beginning of the study, coinciding with the highest FECs. Production of L3 were similar for both groups, when evaluating faecal cultures kept in vitro or L3 recovered from pasture samples and from faecal pats collected from the paddocks, which suggests that both isolates have the same potential of development in vitro and in the environment. The degree of resistance/susceptibility to thiabendazole (TIA), le... Mostrar Tudo |
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Palavras-Chave: |
Anthelmintic Resistance; Nematodes; Parasitic Control; Refugia. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 03176naa a2200277 a 4500
001 2156181
005 2023-08-29
008 2023 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.smallrumres.2023.107063$2DOI
100 1 $aCHOCOBAR, M. L. E.
245 $aBiotic potential and pathogenicity of a Haemonchus contortus susceptible laboratory isolate compared to a resistant field isolate in Brazil.$h[electronic resource]
260 $c2023
300 $a10 p.
520 $aThe high prevalence of anthelmintic resistance of Haemonchus contortus is threatening sheep farming. In this context, resistant populations? replacement using susceptible isolates appears to be a strategy to overcome this situation. The aim of the present study was to evaluate the ability of a susceptible H. contortus laboratory isolate in comparison with a multiresistant field isolate to infect lambs and to study its behaviour in field conditions. Sixteen worm-free lambs were experimentally infected with 4000 infective larvae (L3) of a H. contortus anthelmintic-resistant field isolate (Group R, n = 8) or a laboratory isolate susceptible to anthelmintics (Group S, n = 8). Groups were placed in separate clean pastures, where they were kept for 266 days. Faecal egg counts (FEC) showed maximum values between 21- and 42-days post-infection (PI) and decreased over time, with no statistical differences between groups (P > 0.05). The pathogenicity of the isolates was similar, as lambs from both groups showed a decrease in packed cell volume and total plasma protein values in the beginning of the study, coinciding with the highest FECs. Production of L3 were similar for both groups, when evaluating faecal cultures kept in vitro or L3 recovered from pasture samples and from faecal pats collected from the paddocks, which suggests that both isolates have the same potential of development in vitro and in the environment. The degree of resistance/susceptibility to thiabendazole (TIA), levamisole (LEV), monepantel (MON) and ivermectin (IVE) was evaluated using the Larval Development Assay (RESISTA-Test©) 160 days PI. The resistant isolate showed a high resistance factor (RF) to TIA (141), LEV (822), MON (34) and IVE (196), while the RF of the susceptible isolate remained below three, which indicates high susceptibility to all drugs tested. Our study demonstrates that the susceptible isolate was able to infect lambs and did not show higher pathogenicity nor any differences on its biotic potential when compared to the resistant field isolate. These results indicate that the susceptible isolate has the potential to be used to replace a resistant population of H. contortus, which should be validated in long-term studies under commercial sheep farming conditions.
653 $aAnthelmintic Resistance
653 $aNematodes
653 $aParasitic Control
653 $aRefugia
700 1 $aBELLO, H. J. S.
700 1 $aBASSETTO, C. C.
700 1 $aSILVA-MARINHO, N. M.
700 1 $aSATO, L. M. N.
700 1 $aSPERB, C.
700 1 $aCHAGAS, A. C. de S.
700 1 $aAMARANTE, A. F. T.
773 $tSmall Ruminant Research$gv. 227, oct. 2023, 107063.
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Registro original: |
Embrapa Pecuária Sudeste (CPPSE) |
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| Registros recuperados : 8 | |
| 1. |  | UTIAMADA, C. M.; HIGASHI, W. H.; SCHNEIDER, V. P.; SATO, L. M.; YORINORI, J. T. Época de aplicação de fungicida para o controle de mancha alvo (Corynespora cassiicola) em soja. Fitopatologia Brasileira, v. 23, p. 289, ago. 1998. Suplemento, ref. 444. Edição dos Resumos do XXXIII Congresso Brasileiro de Fitopatologia, Belem, ago. 2000.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Soja. |
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| 2. | | TRÊS, E. F.; GONZAGA, A. C. de O.; BARBOSA, F. R.; LIMA, I. M. de; GASPARETTO, C. A.; SATO, L. M.; CAMPOS, F. T. Artrópodes-pragas e predadores (Arthropoda) associados à cultura do feijoeiro na região de Cristalina-GO. In: CONGRESSO BRASILEIRO DE ENTOMOLOGIA, 23., 2010, Natal. Anais... Natal: Sociedade Brasileira de Entomologia, 2010. 1 CD-ROM.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Arroz e Feijão. |
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| 3. | | ZULIAN, D. F.; SAUL, F. A. C.; OLIVEIRA JÚNIOR, J.; SATO, L. M.; CAMBUIM, J.; CAPO, L. F. M.; MORAES, M. L. T. de; AGUIAR, A. V. de. Proporção sexual de uma população base de Myracrodruon urundeuva em Selvíria, MS. Pesquisa Florestal Brasileira, Colombo, v. 39, (nesp), e201902043, 2019. p. 514. Edição especial dos resumos do IUFRO World Congress, 25., 2019, Curitiba.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Florestas. |
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| 4. | | MACHADO, D. L.; ENGEL, V. L.; PODADERA, D. S.; SATO, L. M.; GOEDE, R. G. M. de; MORAES, L. F. D. de; PARROTA, J. A. Edaphic properties drive the effects of vegetation coposition on litter fall and nutrient inputin tropical seasonal forest restoration systems. In: WORLD CONFERENCE ON ECOLOGICAL RESTORATION, 7.; CONGRESO IBEROAMERICANO Y DEL CARIBE DE RESTAURACIÓN ECOLÓGICA, 5.; CONFERÊNCIA BRASILEIRA DE RESTAURAÇÃO ECOLÓGICA, 1., 2017, Foz do Iguassu. Linking science and practice for a better world: book of abstracts. Londrina: Sociedade Brasileira de Restauração Ecológica, 2017. p. 42| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agrobiologia. |
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| 6. | | CHOCOBAR, M. L. E.; BELLO, H. J. S.; BASSETTO, C. C.; SILVA-MARINHO, N. M.; SATO, L. M. N.; SPERB, C.; CHAGAS, A. C. de S.; AMARANTE, A. F. T. Biotic potential and pathogenicity of a Haemonchus contortus susceptible laboratory isolate compared to a resistant field isolate in Brazil. Small Ruminant Research, v. 227, oct. 2023, 107063. 10 p.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 7. | | BARBOSA, F. R.; GONZAGA, A. C. de O.; SILVEIRA, P. M. da; SILVA, C. C. da; QUINTELA, E. D.; LOBO JUNIOR, M.; COBUCCI, T.; LIMA, I. M. de; GASPARETTO, C. A.; PRADO, L. de S.; SATO, L. M. Validação do sistema de produção integrada do feijão comum (Phaseolus vulgaris L.) na região central brasileira. Santo Antônio de Goiás: Embrapa Arroz e Feijão, 2010. 8 p. (Embrapa Arroz e Feijão. Circular técnica, 87).| Biblioteca(s): Embrapa Arroz e Feijão. |
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| 8. | | BARBOSA, F. R.; SILVEIRA, P. M. da; SILVA, C. C. da; GONZAGA, A. C. de O.; QUINTELA, E. D.; LOBO JUNIOR, M.; LIMA, I. M. de; GASPARETTO, C. A.; PRADO, L. de S.; SATO, L. M. Unidades piloto do sistema de produção integrada de feijão comum (Phaseolus vulgaris L.) em plantios irrigados. In: SEMINÁRIO BRASILEIRO DE PRODUÇÃO INTEGRADA DE FRUTAS, 11.; SEMINÁRIO SOBRE SISTEMA AGROPECUÁRIO DE PRODUÇÃO INTEGRADA, 3., 2009, Petrolina. Produção integrada: base de sustentabilidade para a agropecuária brasileira: resumos... Petrolina: Embrapa Semi-Árido, 2009. 1 CD-ROM.| Tipo: Artigo em Anais de Congresso / Nota Técnica |
| Biblioteca(s): Embrapa Arroz e Feijão. |
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| Registros recuperados : 8 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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