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| Registros recuperados : 72 | |
| 9. |  | OLIVEIRA, L. A. A.; BARRETO, L. P.; BEZERRA NETO, E.; SANTOS, M. V. F. dos; COSTA, J. de C. A. Solutos orgânicos em genótipos de sorgo forrageiro sob estresse salino. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 41, n. 1, p. 31-35, jan. 2006 Título em inglês: Organic solutes in forage sorghum genotypes under saline stress.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 11. | | SANTOS, M. V. F. dos; LIRA, H. de A.; FARIAS, I.; NASCIMENTO, M. M. A.; SANTOS, M. E. P. dos. Produção e composição química de artículos da palma forrageira em diferentes idades. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 25., 1988, Viçosa, MG. Anais... Viçosa, MG: Sociedade Brasileira de Zootecnia, 1988. p. 188.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 15. | | SANTOS, M. V. F. dos; LIRA, M. de A.; FARIAS, I.; BURITY, H. A.; TAVARES FILHO, J. J. Efeito do Periodo de Armazenamento Pos-colheita sobre o Teor de Materia Seca e Composicao Quimica das Palmas Forrageiras. Pesquisa Agropecuaria Brasileira, Brasilia, v.27, n.6, p.777-783, jun.1992| Biblioteca(s): Embrapa Unidades Centrais. |
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| 16. | | VÉRAS, A. S. C.; MELO, W. S. de; SANTOS, M. V. F. dos; SANTOS, G. R. A. dos. Estratégias de suplementação alimentar a pasto para ruminantes: perspectivas para o Nordeste brasileiro. In: CONGRESSO NORDESTINO DE PRODUÇÃO ANIMAL, 4.; SIMPÓSIO NORDESTINO DE ALIMENTAÇÃO DE RUMINANTES, 10.; SIMPÓSIO DE PRODUÇÃO ANIMAL DO VALE DO SÃO FRANCISCO, 1., 2006, Petrolina. Anais... Petrolina: Sociedade Nordestina de Produção Animal; Embrapa Semi-Arido, 2006. p. 99-123. 1 CD-ROM.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 17. | | SILVA, M. da C.; FREITAS, E. V.; SANTOS, D. C. dos; CAMARA, T. M. M.; SANTOS, M. V. F. dos; LIRA, M. de A.; SILVA, F. L. da. Seleção inicial de clones de Pennisetum spp. para geração de energia renovável. In: CONGRESSO NORDESTINO DE PRODUÇÃO ANIMAL, 12.; SIMPÓSIO NORDESTINO DE ALIMENTAÇÃO DE RUMINANTES, 18.; SIMPÓSIO NORDESTINO DE SISTEMAS DE PRODUÇÃO DE RUMINANTES, 5.; SIMPÓSIO DE PRODUÇÃO ANIMAL DO VALE DO SÃO FRANCISCO, 6.; SIMPÓSIO NORDESTINO DE FORRAGICULTURA E PASTAGENS, 5.; SIMPÓSIO NORDESTINO DE CONSERVAÇÃO E UTILIZAÇÃO DE RECURSOS GENÉTICOS ANIMAIS, 6.; SIMPÓSIO NORDESTINO SOBRE AMBIÊNCIA, BEM-ESTAR ANIMAL E CONVIVÊNCIA COM O SEMIÁRIDO, 1.; SIMPÓSIO IMPORTÂNCIA DAS PASTAGENS NATIVAS PARA A SUSTENTABILIDADE PECUÁRIA NO SEMIÁRIDO; FÓRUM DE COORDENADORES DE PROGRAMAS DE PÓS-GRADUAÇÃO EM ZOOTECNIA E RECURSOS PESQUEIROS DO NORDESTE, 7.; FÓRUM DE INTEGRAÇÃO ENTRE A ACADEMIA, AGENTES DE EXTENSÃO RURAL E PRODUTORES, 1. 2017, Juazeiro, BA. Construindo pontes entre o ensino, a pesquisa e a extensão: anais. Petrolina: Univasf: Embrapa Semiárido: Instituto Federal de Educação, Ciência e Tecnologia, Sertão de Pernambuco, 2017. p. 2031-2033. 1 CD-ROM.| Biblioteca(s): Embrapa Tabuleiros Costeiros. |
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| 18. | | MOREIRA, J. N.; LIRA, M. de A.; SANTOS, M. V. F. dos; FERREIRA, M. de A.; MELO, A. A. S. de. Substituição do farelo de soja por uréia na suplementação de vacas leiteiras no sertão pernambucano. Caatinga, Mossoró, v. 20, n. 3, p. 28-35, jul./set. 2007.| Biblioteca(s): Embrapa Semiárido. |
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| 19. | | SANTOS, O. O. DOS; ARAUJO, G. G. L. de; MISTURA, C.; PEREIRA, L. G. R.; VOLTOLINI, T. V.; SANTOS, M. V. F. DOS; ARAÚJO, J. R. DE. Fermentation characteristics and nutritional value of elephant grass ensiled with old man saltbush. Revista Brasileira de Zootecnia, v. 41, n. 6, p. 1401-1406, 2012.| Biblioteca(s): Embrapa Gado de Leite; Embrapa Semiárido. |
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| 20. | | DUBEUX JUNIOR, J. C. B.; SANTOS, M. V. F. dos; SANTOS, D. C. dos; FARIAS, I.; MESQUITA FILHO, L. F.; MATOS, C. W.; CABRAL, M. T. de L. Índice de área de cladódio de palma forrageira cv IPA-20 (Opuntia ficus-indica Mill) submetida a diferentes espaçamentos e adubações. In: CONGRESSO NORDESTINO DE PRODUÇÃO ANIMAL 2.; SIMPÓSIO NORDESTINO DE ALIMENTAÇÃO DE RUMINANTES, 8., 2000, Teresina. Resumos... Teresina: Sociedade Nordestina de Produção Animal, 2000. v. 2. p. 100-103.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| Registros recuperados : 72 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Suínos e Aves. |
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Data corrente: |
12/08/2022 |
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Data da última atualização: |
12/08/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
IBELLI, A. M. G.; PEIXOTO, J. de O.; ZANELLA, R.; GOUVEIA, J. J. de S.; CANTAO, M. E.; COUTINHO, L. L.; MARCHESI, J. A. P.; DAL PIZZOL, M. S.; MARCELINO, D. E. P.; LEDUR, M. C. |
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Afiliação: |
ADRIANA MERCIA GUARATINI IBELLI, CNPSA; JANE DE OLIVEIRA PEIXOTO, CNPSA; RICARDO ZANELLA, UPF; JOÃO JOSÉ DE SIMONI GOUVEIA, UNIVASF; MAURICIO EGIDIO CANTAO, CNPSA; LUIZ LEHMANN COUTINHO, Esalq; JORGE AUGUSTO PETROLI MARCHESI, USP; MARIANE SPUDEIT DAL PIZZOL, UDESC/Chapecó; DÉBORA ESTER PETRY MARCELINO, FACC; MONICA CORREA LEDUR, CNPSA. |
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Título: |
Downregulation of growth plate genes involved with the onset of femoral head separation in young broilers. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Frontiers in Physiology, v. 3, n. 941134, 2022. doi: 10.3389/fphys.2022.941134 |
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DOI: |
https://doi.org/10.3389/fphys.2022.941134 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Femoral head separation (FHS) is characterized by the detachment of growth plate (GP) and articular cartilage, occurring in tibia and femur. However, the molecular mechanisms involved with this condition are not completely understood. Therefore, genes and biological processes (BP) involved with FHS were identified in 21-day-old broilers through RNA sequencing of the femoral GP. 13,487 genes were expressed in the chicken femoral head transcriptome of normal and FHS-affected broilers. From those, 34 were differentially expressed (DE; FDR ≤0.05) between groups, where all of them were downregulated in FHS-affected broilers. The main BP were enriched in receptor signaling pathways, ossification, bone mineralization and formation, skeletal morphogenesis, and vascularization. RNA-Seq datasets comparison of normal and FHS-affected broilers with 21, 35 and 42 days of age has shown three shared DE genes (FBN2, C1QTNF8, and XYLT1) in GP among ages. Twelve genes were exclusively DE at 21 days, where 10 have already been characterized (SHISA3, FNDC1, ANGPTL7, LEPR, ENSGALG00000049529, OXTR, ENSGALG00000045154, COL16A1, RASD2, BOC, GDF10, and THSD7B). Twelve SNPs were associated with FHS (p < 0.0001). Out of those, 5 were novel and 7 were existing variants located in 7 genes (RARS, TFPI2, TTI1, MAP4K3, LINK54, and AREL1). We have shown that genes related to chondrogenesis and bone differentiation were downregulated in the GP of FHS-affected young broilers. Therefore, these findings evince that candidate genes pointed out in our study are probably related to the onset of FHS in broilers. MenosAbstract: Femoral head separation (FHS) is characterized by the detachment of growth plate (GP) and articular cartilage, occurring in tibia and femur. However, the molecular mechanisms involved with this condition are not completely understood. Therefore, genes and biological processes (BP) involved with FHS were identified in 21-day-old broilers through RNA sequencing of the femoral GP. 13,487 genes were expressed in the chicken femoral head transcriptome of normal and FHS-affected broilers. From those, 34 were differentially expressed (DE; FDR ≤0.05) between groups, where all of them were downregulated in FHS-affected broilers. The main BP were enriched in receptor signaling pathways, ossification, bone mineralization and formation, skeletal morphogenesis, and vascularization. RNA-Seq datasets comparison of normal and FHS-affected broilers with 21, 35 and 42 days of age has shown three shared DE genes (FBN2, C1QTNF8, and XYLT1) in GP among ages. Twelve genes were exclusively DE at 21 days, where 10 have already been characterized (SHISA3, FNDC1, ANGPTL7, LEPR, ENSGALG00000049529, OXTR, ENSGALG00000045154, COL16A1, RASD2, BOC, GDF10, and THSD7B). Twelve SNPs were associated with FHS (p < 0.0001). Out of those, 5 were novel and 7 were existing variants located in 7 genes (RARS, TFPI2, TTI1, MAP4K3, LINK54, and AREL1). We have shown that genes related to chondrogenesis and bone differentiation were downregulated in the GP of FHS-affected young broilers. Therefore, these... Mostrar Tudo |
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Palavras-Chave: |
FBN2; Femoral head necrosis; FHS; Necrose da cabeça femoral; RNA-Seq. |
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Thesagro: |
Frango; Galinha; Genética Animal. |
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Thesaurus NAL: |
Chickens; Gene expression. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1145416/1/final9937.pdf
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Marc: |
LEADER 02692naa a2200361 a 4500
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024 7 $ahttps://doi.org/10.3389/fphys.2022.941134$2DOI
100 1 $aIBELLI, A. M. G.
245 $aDownregulation of growth plate genes involved with the onset of femoral head separation in young broilers.$h[electronic resource]
260 $c2022
520 $aAbstract: Femoral head separation (FHS) is characterized by the detachment of growth plate (GP) and articular cartilage, occurring in tibia and femur. However, the molecular mechanisms involved with this condition are not completely understood. Therefore, genes and biological processes (BP) involved with FHS were identified in 21-day-old broilers through RNA sequencing of the femoral GP. 13,487 genes were expressed in the chicken femoral head transcriptome of normal and FHS-affected broilers. From those, 34 were differentially expressed (DE; FDR ≤0.05) between groups, where all of them were downregulated in FHS-affected broilers. The main BP were enriched in receptor signaling pathways, ossification, bone mineralization and formation, skeletal morphogenesis, and vascularization. RNA-Seq datasets comparison of normal and FHS-affected broilers with 21, 35 and 42 days of age has shown three shared DE genes (FBN2, C1QTNF8, and XYLT1) in GP among ages. Twelve genes were exclusively DE at 21 days, where 10 have already been characterized (SHISA3, FNDC1, ANGPTL7, LEPR, ENSGALG00000049529, OXTR, ENSGALG00000045154, COL16A1, RASD2, BOC, GDF10, and THSD7B). Twelve SNPs were associated with FHS (p < 0.0001). Out of those, 5 were novel and 7 were existing variants located in 7 genes (RARS, TFPI2, TTI1, MAP4K3, LINK54, and AREL1). We have shown that genes related to chondrogenesis and bone differentiation were downregulated in the GP of FHS-affected young broilers. Therefore, these findings evince that candidate genes pointed out in our study are probably related to the onset of FHS in broilers.
650 $aChickens
650 $aGene expression
650 $aFrango
650 $aGalinha
650 $aGenética Animal
653 $aFBN2
653 $aFemoral head necrosis
653 $aFHS
653 $aNecrose da cabeça femoral
653 $aRNA-Seq
700 1 $aPEIXOTO, J. de O.
700 1 $aZANELLA, R.
700 1 $aGOUVEIA, J. J. de S.
700 1 $aCANTAO, M. E.
700 1 $aCOUTINHO, L. L.
700 1 $aMARCHESI, J. A. P.
700 1 $aDAL PIZZOL, M. S.
700 1 $aMARCELINO, D. E. P.
700 1 $aLEDUR, M. C.
773 $tFrontiers in Physiology$gv. 3, n. 941134, 2022. doi: 10.3389/fphys.2022.941134
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Embrapa Suínos e Aves (CNPSA) |
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