Data/hora: 17/06/2024 02:36:37

Biblioteca(s): 	Embrapa Unidades Centrais.	
Data corrente: 	31/01/2018	
Data da última atualização: 	31/01/2018	
Autoria: 	ESTIMA-SILVA, P.; MARCOLONGO-PEREIRA, C.; SANTOS, B. L. dos; COELHO, A. C. B.; AMARAL, L. A.; LIM, A.; BOLIN, S. R.; SCHILD, A. L.	
Afiliação: 	Pablo Estima-Silva, Programa de Pós-Graduação em Veterinária/Faculdade de Veterinária - FV/Universidade Federal de Pelotas - UFPel; Clairton Marcolongo-Pereira, Faculdade de Veterinária/Centro Universitário Ritter dos Reis - UniRitter; Bianca Lemos dos Santos, Programa de Pós-Graduação em Veterinária/Faculdade de Veterinária - FV/Universidade Federal de Pelotas - UFPel; Ana Carolina Barreto Coelho, Programa de Pós-Graduação em Veterinária/Faculdade de Veterinária - FV/Universidade Federal de Pelotas - UFPel; Lorena Alvariza Amaral, Médica Veterinária Autônoma; Ailam Lim, Diagnostic Center for Population and Animal Health, Michigan State University; Steven R. Bolin, Diagnostic Center for Population and Animal Health/Michigan State University; Ana Lucia Schild, Laboratório Regional de Diagnóstico/Faculdade de Veterinária - UFPel.	
Título: 	Equine multinodular pulmonary fibrosis in southern Brazil: pathology and differential diagnosis.	
Ano de publicação: 	2017	
Fonte/Imprenta: 	Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 37, n. 11, p. 1247-1252, novembro 2017.	
Idioma: 	Inglês	
Notas: 	Título em português: Fibrose pulmonar multinodular em equinos no Sul do Rio Grande do Sul: patologia e diagnóstico diferencial.	
Conteúdo: 	Equine multinodular pulmonary fibrosis (EMPF) diagnosed at the Laboratório Regional de Diagnóstico of Faculdade de Medicina Veterinária, Universidade Federal de Pelotas (LRD/UFPel), is described. Differential aspects of other pulmonary diseases in horses with pneumonia and interstitial fibrosis were discussed. The disease occurred in a 15-year-old equine that presented with clinical signs of respiratory distress, intermittent fever, anorexia, and dyspnea. Macroscopically, there was enlargement of the lungs with whitish, pale, firm and well-delimited nodules, approximately 7-10 cm in diameter, distributed throughout the parenchyma. Histologically, the lung nodules had alveolar spaces with walls covered by cuboidal epithelium containing macrophages, neutrophils, lymphocytes, hyperplasia of type II pneumocytes and, eventually, multinucleated giant cells. The interstitium was markedly thickened by mature fibrous connective tissue and collagen. There were intranuclear inclusion bodies in the macrophages. The PCR technique for detecting the EHV-5 DNA was positive. In a retrospective study of pneumonia cases in horses with interstitial fibrosis diagnosed in the LRD/UFPel, two animals had macroscopic and histological lesions similar to those with EMPF, but they were negative for EHV-5 in PCR. Four cases diagnosed with pneumonia and interstitial tissue fibrosis had a histological pattern that was different from that observed in the EMPF animal, thus eliminating the possibility of EMPF. It is concluded that EMPF is a sporadic disease that should be considered in cases of respiratory disease in horses. Reports of such cases are important to alert technicians about the occurrence of rare diseases in Brazil. It is also necessary to establish the true role of EHV-5 in the pathogenesis of EMPF. Cases of pulmonary fibrosis such as EMPF, in which the virus is not present, should be studied to establish whether it could be an idiopathic form of the disease.	
Palavras-Chave: 	Diagnóstico diferencial; Differential diagnosis; Disease of horses; Doença pulmonar; Equine multinodular pulmonary fibrosis; Fibrose pulmonar multinodular; Herpesvírus equino-5; Pathology; Retrospective study.	
Thesagro: 	Doença; Eqüino.	
Categoria do assunto: 	--	
URL: 	http://ainfo.cnptia.embrapa.br/digital/bitstream/item/171993/1/Equine-multinodular-pulmonary-fibrosis.pdf	
Registro original: 	Embrapa Unidades Centrais (AI-SEDE)	
Exemplares: 	AI-SEDE - (62180-1) - UPE - AP - DD -  -  -  - DIS