Data/hora: 22/09/2024 19:46:42

Biblioteca(s): 	Embrapa Clima Temperado.	
Data corrente: 	21/06/2022	
Data da última atualização: 	21/06/2022	
Autoria: 	HAAS, C. S.; OLIVEIRA, F. C.; ROVANI, M. T.; FERST, J. G.; VARGAS JUNIOR, S. F.; VIEIRA, A. D.; MONDADORI, R. G.; PEGORARO, L. M. C.; GONÇALVES, P. B. D.; BORDIGNON, V.; FERREIRA, R.; GASPERIN, B. G.	
Afiliação: 	CRISTINA S. HAAS, UFPEL; FERNANDO C. OLIVEIRA, UFPEL; MONIQUE T. ROVANI, UFRGS; JULIANA G. FERST, Federal University of Pampa; SERGIO FARIAS VARGAS JR, UFPEL; ARNALDO D. VIEIRA, UFPEL; RAFAEL GIANELLA MONDADORI, UFPEL; LIGIA MARGARETH CANTARELLI PEGORARO, CPACT; PAULO B. D. GONÇALVES, Federal University of Pampa; VILCEU BORDIGNON, McGill University; ROGÉRIO FERREIRA, Santa Catarina State University; BERNARDO G. GASPERIN, UFPEL.	
Título: 	Bone morphogenetic protein 15 intrafollicular injection inhibits ovulation in cattle.	
Ano de publicação: 	2022	
Fonte/Imprenta: 	Theriogenology, v. 182, p. 148-154, 2022.	
ISSN: 	0093-691X	
DOI: 	doi.org/10.1016/j.theriogenology.2022.02.010	
Idioma: 	Inglês	
Notas: 	Available online 10 February 2022.	
Conteúdo: 	Oocyte-derived bone morphogenetic protein 15 (BMP15) is one of the main local regulators of ovarian physiology, but its role in the regulation of preovulatory follicles and ovulation is not well established. Therefore, this study was conceived to determine the effect of intrafollicular injection (IFI) of BMP15 on final follicular growth, ovulation and luteinization in cattle. Initially, it was observed that relative mRNA abundance of the BMP15 receptor BMPR1B in granulosa cells was regulated by GnRH treatment, and it was negatively correlated (R2 = 0.5; P < 0.001) to progesterone concentration in follicular fluid (FF) from preovulatory follicles. The IFI of recombinant human BMP15 tended to inhibit the growth of dominant follicles, as evidenced by an average increase of only 7.7% in the follicular diameter (from 8.8 mm to 9.1 mm) at 36 h post injection compared to 36.4% increase (from 8.9 mm to 14 mm) in the control group. Injection of BMP15 into preovulatory follicles (12?14 mm), simultaneously to im GnRH treatment, inhibited ovulation compared to control group, but did not prevent luteinization and progesterone production. Most of preovulatory follicles injected with BMP15 became luteinized cysts. Collectively, these findings indicate a suppressive role of BMP15 on later follicular development and ovulation in cattle, but not on luteogenesis and progesterone secretion.	
Palavras-Chave: 	BMP15; Crescimento folicular; Luteinização; Oócito.	
Thesagro: 	Bovino; Corpo Lúteo; Fertilidade; Gado; Ovulação.	
Categoria do assunto: 	--	
Registro original: 	Embrapa Clima Temperado (CPACT)	
Exemplares: 	CPACT - (22296-1) - UPC - AP - DD -  -  -  - DIS