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Biblioteca(s): |
Embrapa Unidades Centrais. |
Data corrente: |
30/04/2018 |
Data da última atualização: |
30/04/2018 |
Autoria: |
NOGUEIRA, S. S. S.; SOUSA, M. G.; GAVA, F. N.; ROSA, F. A.; MELO, G. D.; DITTRICH, G.; MACHADO, G. F.; CAMACHO, A. A. |
Afiliação: |
Sheila S. S. Nogueira, Departamento de Clínica e Cirurgia Veterinária/Universidade Estadual Paulista - Unesp; Marlos G. Sousa, Departamento de Medicina Veterinária/Universidade Federal do Paraná - UFPR; Fabio N. Gava, Departamento de Clínica e Cirurgia Veterinária/Universidade Estadual Paulista - Unesp; Fernando A. Rosa, Departamento de Clínica e Cirurgia Veterinária/Universidade Estadual Paulista - Unesp; Guilherme D. Melo, Departamento de Clínica/Cirurgia e Reprodução Animal/Unesp; Gustavo Dittrich, Departamento de Medicina Veterinária/Universidade Federal do Paraná - UFPR; Gisele F. Machado, Departamento de Clínica/Cirurgia e Reprodução Animal/Unesp; Aparecido A. Camacho, Departamento de Clínica e Cirurgia Veterinária/Universidade Estadual Paulista - Unesp. |
Título: |
Matrix metalloproteinases 2 and 9 in rabbits with doxorubicin-induced cardiomyopathy. |
Ano de publicação: |
2018 |
Fonte/Imprenta: |
Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 38, n. 2, p. 320-327, fevereiro 2018 |
Idioma: |
Inglês |
Notas: |
Título em português: Metaloproteinases de matriz 2 e 9 em coelhos com cardiomiopatia induzida pela doxorrubicina. |
Conteúdo: |
Some studies have shown the role played by matrix metalloproteinases and their inhibitors in doxorubicin cardiotoxicity. In this study, we sought to investigate how plasma and myocardial MMP 2 and 9 perform in rabbits with doxorubicin-induced cardiomyopathy, searching for a correlation between the activity of these collagenases and cardiac remodeling. Cardiomyopathy was induced by doxorubicin given intravenously twice a week for six consecutive weeks. Plasma MMP activity and the echocardiogram were assessed at baseline, and at 15 and 45 days after first injection of doxorubicin. The myocardial activity of these enzymes was solely evaluated in nine rabbits at 45 days, and results were compared with nine healthy controls. We only identified the full-length forms of both MMP 2 and 9 throughout the study. The plasma pro-MMP 2 reduced along the deterioration of cardiac function, while the pro-MMP 9 increased significantly at T45 as compared to baseline and T15. A negative significant correlation was found to exist between the plasma activity of pro-MMP 2 and mitral E-to-mitral septal annular early diastolic velocity ratio, which is an estimate of mean left atrial pressure and congestion. Only pro-MMP 2 was found in myocardial samples,and mean activity of such enzyme was statistically lower than that recorded for healthy controls. Although no active form was documented for either collagenase, the duration of the treatment with doxorubicin played a role in the alteration of plasma pro-forms activity. However, these changes could not be associated with most echocardiographic parameters that are supportive of cardiac remodeling. MenosSome studies have shown the role played by matrix metalloproteinases and their inhibitors in doxorubicin cardiotoxicity. In this study, we sought to investigate how plasma and myocardial MMP 2 and 9 perform in rabbits with doxorubicin-induced cardiomyopathy, searching for a correlation between the activity of these collagenases and cardiac remodeling. Cardiomyopathy was induced by doxorubicin given intravenously twice a week for six consecutive weeks. Plasma MMP activity and the echocardiogram were assessed at baseline, and at 15 and 45 days after first injection of doxorubicin. The myocardial activity of these enzymes was solely evaluated in nine rabbits at 45 days, and results were compared with nine healthy controls. We only identified the full-length forms of both MMP 2 and 9 throughout the study. The plasma pro-MMP 2 reduced along the deterioration of cardiac function, while the pro-MMP 9 increased significantly at T45 as compared to baseline and T15. A negative significant correlation was found to exist between the plasma activity of pro-MMP 2 and mitral E-to-mitral septal annular early diastolic velocity ratio, which is an estimate of mean left atrial pressure and congestion. Only pro-MMP 2 was found in myocardial samples,and mean activity of such enzyme was statistically lower than that recorded for healthy controls. Although no active form was documented for either collagenase, the duration of the treatment with doxorubicin played a role in the alteration of plasma ... Mostrar Tudo |
Palavras-Chave: |
Cardiomiopatia; Doxorrubicina; Echocardiogram; Ecocardio; MetaloproteinaseS; Zimografia; Zymography. |
Thesagro: |
Atividade Enzimática; Cardiopatia; Coelho. |
Thesaurus Nal: |
Cardiomyopathy; Collagenase; Doxorubicin; Enzyme activity; Heart diseases; Metalloproteinases; Rabbits. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/176152/1/Matrix-metalloproteinases-2-and-9-in-rabbits.pdf
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Marc: |
LEADER 02913naa a2200421 a 4500 001 2091049 005 2018-04-30 008 2018 bl uuuu u00u1 u #d 100 1 $aNOGUEIRA, S. S. S. 245 $aMatrix metalloproteinases 2 and 9 in rabbits with doxorubicin-induced cardiomyopathy.$h[electronic resource] 260 $c2018 500 $aTítulo em português: Metaloproteinases de matriz 2 e 9 em coelhos com cardiomiopatia induzida pela doxorrubicina. 520 $aSome studies have shown the role played by matrix metalloproteinases and their inhibitors in doxorubicin cardiotoxicity. In this study, we sought to investigate how plasma and myocardial MMP 2 and 9 perform in rabbits with doxorubicin-induced cardiomyopathy, searching for a correlation between the activity of these collagenases and cardiac remodeling. Cardiomyopathy was induced by doxorubicin given intravenously twice a week for six consecutive weeks. Plasma MMP activity and the echocardiogram were assessed at baseline, and at 15 and 45 days after first injection of doxorubicin. The myocardial activity of these enzymes was solely evaluated in nine rabbits at 45 days, and results were compared with nine healthy controls. We only identified the full-length forms of both MMP 2 and 9 throughout the study. The plasma pro-MMP 2 reduced along the deterioration of cardiac function, while the pro-MMP 9 increased significantly at T45 as compared to baseline and T15. A negative significant correlation was found to exist between the plasma activity of pro-MMP 2 and mitral E-to-mitral septal annular early diastolic velocity ratio, which is an estimate of mean left atrial pressure and congestion. Only pro-MMP 2 was found in myocardial samples,and mean activity of such enzyme was statistically lower than that recorded for healthy controls. Although no active form was documented for either collagenase, the duration of the treatment with doxorubicin played a role in the alteration of plasma pro-forms activity. However, these changes could not be associated with most echocardiographic parameters that are supportive of cardiac remodeling. 650 $aCardiomyopathy 650 $aCollagenase 650 $aDoxorubicin 650 $aEnzyme activity 650 $aHeart diseases 650 $aMetalloproteinases 650 $aRabbits 650 $aAtividade Enzimática 650 $aCardiopatia 650 $aCoelho 653 $aCardiomiopatia 653 $aDoxorrubicina 653 $aEchocardiogram 653 $aEcocardio 653 $aMetaloproteinaseS 653 $aZimografia 653 $aZymography 700 1 $aSOUSA, M. G. 700 1 $aGAVA, F. N. 700 1 $aROSA, F. A. 700 1 $aMELO, G. D. 700 1 $aDITTRICH, G. 700 1 $aMACHADO, G. F. 700 1 $aCAMACHO, A. A. 773 $tPesquisa Veterinária Brasileira, Rio de Janeiro$gv. 38, n. 2, p. 320-327, fevereiro 2018
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Embrapa Unidades Centrais (AI-SEDE) |
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Biblioteca(s): |
Embrapa Arroz e Feijão. |
Data corrente: |
06/03/2006 |
Data da última atualização: |
05/05/2022 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
CUNHA, W. G. da; RAMALHO, M. A. P.; ABREU, A. de F. B. |
Afiliação: |
WELCIMAR GONÇALVES DA CUNHA, UFLA; MAGNO ANTONIO PATTO RAMALHO, UFLA; ANGELA DE FATIMA BARBOSA ABREU, CNPAF. |
Título: |
Selection aiming at upright growth habit common bean with carioca type grains. |
Ano de publicação: |
2005 |
Fonte/Imprenta: |
Crop Breeding and Applied Biotechnology, v. 5, n. 4, p. 379-386, Dec. 2005. |
DOI: |
10.12702/1984-7033.V05N04A02 |
Idioma: |
Inglês |
Conteúdo: |
Aiming at common bean lines with a high grain yield, upright growth habit and carioca type grains, ten common bean lines were crossed in a diallel scheme. The resulting populations were evaluated as to their capacity of generating superior lines. Eleven of the 42 evaluated populations were chosen to form the base population (S0) of the first cycle (C-0). The resultant families were evaluated up to the S0:5 generation for yield, plant architecture and grain type. In this generation, a total of 14 families was evaluated with two controls to estimate the genetic gain considering the three traits of interest together. The obtained genetic gain was 3.1% after one selection cycle, confirming the efficiency of the realized selection. The estimates of genetic and phenotypic parameters in the different generations associated to the mean family performance allow a prediction of the success of recurrent selection in future cycles. |
Palavras-Chave: |
Arquitetura da planta; Common bean; Ganho genético; Genetic gain; Upright growth habit; Yield. |
Thesagro: |
Feijão; Melhoramento Genético Vegetal; Phaseolus Vulgaris; Produção; Seleção Recorrente. |
Thesaurus NAL: |
recurrent selection. |
Categoria do assunto: |
G Melhoramento Genético |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/213879/1/cbab-2005.pdf
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Marc: |
LEADER 01846naa a2200301 a 4500 001 1213879 005 2022-05-05 008 2005 bl uuuu u00u1 u #d 024 7 $a10.12702/1984-7033.V05N04A02$2DOI 100 1 $aCUNHA, W. G. da 245 $aSelection aiming at upright growth habit common bean with carioca type grains.$h[electronic resource] 260 $c2005 520 $aAiming at common bean lines with a high grain yield, upright growth habit and carioca type grains, ten common bean lines were crossed in a diallel scheme. The resulting populations were evaluated as to their capacity of generating superior lines. Eleven of the 42 evaluated populations were chosen to form the base population (S0) of the first cycle (C-0). The resultant families were evaluated up to the S0:5 generation for yield, plant architecture and grain type. In this generation, a total of 14 families was evaluated with two controls to estimate the genetic gain considering the three traits of interest together. The obtained genetic gain was 3.1% after one selection cycle, confirming the efficiency of the realized selection. The estimates of genetic and phenotypic parameters in the different generations associated to the mean family performance allow a prediction of the success of recurrent selection in future cycles. 650 $arecurrent selection 650 $aFeijão 650 $aMelhoramento Genético Vegetal 650 $aPhaseolus Vulgaris 650 $aProdução 650 $aSeleção Recorrente 653 $aArquitetura da planta 653 $aCommon bean 653 $aGanho genético 653 $aGenetic gain 653 $aUpright growth habit 653 $aYield 700 1 $aRAMALHO, M. A. P. 700 1 $aABREU, A. de F. B. 773 $tCrop Breeding and Applied Biotechnology$gv. 5, n. 4, p. 379-386, Dec. 2005.
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