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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Agroindústria Tropical; Embrapa Gado de Leite; Embrapa Instrumentação; Embrapa Pecuária Sudeste. |
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Data corrente: |
25/01/2024 |
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Data da última atualização: |
11/04/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
ANHOLETO, L. A.; BRANCAGLION, G. A.; SANTOS, D. M. DOS; KAPRITCHKOFF, R. T. I.; CASTRO, K. N. de C.; CANUTO, K. M.; RODRIGUES, R. A. F.; CORREA, D. S.; CHAGAS, A. C. de S.; PASTRE, J. C. |
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Afiliação: |
LUIS ADRIANO ANHOLETO; GUILHERME ANDRADE BRANCAGLION, UNIVERSIDADE DE CAMPINAS; DANILO MARTINS DOS SANTOS; RAFAELA TAMI IKEDA KAPRITCHKOFF, UNIVERSIDADE DE SÃO PAULO; KARINA NEOOB DE CARVALHO CASTRO, CNPGL; KIRLEY MARQUES CANUTO, CNPAT; RODNEY ALEXANDRE FERREIRA RODRIGUES, UNIVERSIDADE DE CAMPINAS; DANIEL SOUZA CORREA, CNPDIA; ANA CAROLINA DE SOUZA CHAGAS, CPPSE; JULIO CEZAR PASTRE, UNIVERSIDADE DE CAMPINAS. |
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Título: |
Acaricidal activity of synthetic spilanthol derivative against ticks of medical and veterinary importance. |
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Ano de publicação: |
2024 |
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Fonte/Imprenta: |
Veterinary Parasitology, v. 327, Apr. 2024, 110137. |
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Páginas: |
9 p. |
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DOI: |
10.1016/j.vetpar.2024.110137 |
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Idioma: |
Inglês |
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Conteúdo: |
The ANESPSAT, a synthetic spilanthol derivative, and its nanoformulation were evaluated against Rhipicephalus microplus and Amblyomma sculptum ticks. ANESPSAT activity was compared with spilanthol and derivatives (ANESPE and others). The compound was synthesized in a gram-scale by a 2-step process, comprising a direct ester amidation and a Horner-Wadsworth- Emmons reaction. The nanoemulsions were produced by coarse homogenization followed by high-energy ultrasonication, in which hydrodynamic diameter, polydispersity index, and zeta potential remained stable. The spilanthol-eugenol hybrid derivatives did not show significant acaricidal activity. ANESPE killed 83% of the R. microplus larvae at 30 mg.mL−1, while ANESPSAT killed 97% at 0.5 mg.mL−1, showing to be the most active compound. Spilanthol and ANESPSAT had similar high mortality rates for tick larvae, with LC50 values of 0.10 and 0.14 mg.mL−1 for R. microplus larvae, and 0.04 and 0.48 mg.mL−1 for A. sculptum larvae, respectively. The efficacy of spilanthol was lower against R. microplus engorged females when compared with ANESPSAT, which was highly effective (>98%) against R. microplus engorged females. The nanoemulsion with ANESPSAT was effective against tick females, preventing egg laying and achieving 100% efficacy at 2.5 mg.mL−1. Spilanthol had only 59% efficacy at 10 mg.mL−1. The results suggest that ANESPSAT, a natural product derivative, could be used in novel formulations for tick management that might be safer and environmentally friendly. MenosThe ANESPSAT, a synthetic spilanthol derivative, and its nanoformulation were evaluated against Rhipicephalus microplus and Amblyomma sculptum ticks. ANESPSAT activity was compared with spilanthol and derivatives (ANESPE and others). The compound was synthesized in a gram-scale by a 2-step process, comprising a direct ester amidation and a Horner-Wadsworth- Emmons reaction. The nanoemulsions were produced by coarse homogenization followed by high-energy ultrasonication, in which hydrodynamic diameter, polydispersity index, and zeta potential remained stable. The spilanthol-eugenol hybrid derivatives did not show significant acaricidal activity. ANESPE killed 83% of the R. microplus larvae at 30 mg.mL−1, while ANESPSAT killed 97% at 0.5 mg.mL−1, showing to be the most active compound. Spilanthol and ANESPSAT had similar high mortality rates for tick larvae, with LC50 values of 0.10 and 0.14 mg.mL−1 for R. microplus larvae, and 0.04 and 0.48 mg.mL−1 for A. sculptum larvae, respectively. The efficacy of spilanthol was lower against R. microplus engorged females when compared with ANESPSAT, which was highly effective (>98%) against R. microplus engorged females. The nanoemulsion with ANESPSAT was effective against tick females, preventing egg laying and achieving 100% efficacy at 2.5 mg.mL−1. Spilanthol had only 59% efficacy at 10 mg.mL−1. The results suggest that ANESPSAT, a natural product derivative, could be used in novel formulations for tick management that might be safer ... Mostrar Tudo |
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Palavras-Chave: |
Acmella oleracea; Bovine parasite sadness; Brazilian Spotted Fever; Cattle tick; Control; Nanoformulation; Spilanthol. |
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Thesagro: |
Bovino; Carrapato. |
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Thesaurus Nal: |
Rickettsia rickettsii. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 02636naa a2200373 a 4500
001 2161314
005 2024-04-11
008 2024 bl uuuu u00u1 u #d
024 7 $a10.1016/j.vetpar.2024.110137$2DOI
100 1 $aANHOLETO, L. A.
245 $aAcaricidal activity of synthetic spilanthol derivative against ticks of medical and veterinary importance.$h[electronic resource]
260 $c2024
300 $a9 p.
520 $aThe ANESPSAT, a synthetic spilanthol derivative, and its nanoformulation were evaluated against Rhipicephalus microplus and Amblyomma sculptum ticks. ANESPSAT activity was compared with spilanthol and derivatives (ANESPE and others). The compound was synthesized in a gram-scale by a 2-step process, comprising a direct ester amidation and a Horner-Wadsworth- Emmons reaction. The nanoemulsions were produced by coarse homogenization followed by high-energy ultrasonication, in which hydrodynamic diameter, polydispersity index, and zeta potential remained stable. The spilanthol-eugenol hybrid derivatives did not show significant acaricidal activity. ANESPE killed 83% of the R. microplus larvae at 30 mg.mL−1, while ANESPSAT killed 97% at 0.5 mg.mL−1, showing to be the most active compound. Spilanthol and ANESPSAT had similar high mortality rates for tick larvae, with LC50 values of 0.10 and 0.14 mg.mL−1 for R. microplus larvae, and 0.04 and 0.48 mg.mL−1 for A. sculptum larvae, respectively. The efficacy of spilanthol was lower against R. microplus engorged females when compared with ANESPSAT, which was highly effective (>98%) against R. microplus engorged females. The nanoemulsion with ANESPSAT was effective against tick females, preventing egg laying and achieving 100% efficacy at 2.5 mg.mL−1. Spilanthol had only 59% efficacy at 10 mg.mL−1. The results suggest that ANESPSAT, a natural product derivative, could be used in novel formulations for tick management that might be safer and environmentally friendly.
650 $aRickettsia rickettsii
650 $aBovino
650 $aCarrapato
653 $aAcmella oleracea
653 $aBovine parasite sadness
653 $aBrazilian Spotted Fever
653 $aCattle tick
653 $aControl
653 $aNanoformulation
653 $aSpilanthol
700 1 $aBRANCAGLION, G. A.
700 1 $aSANTOS, D. M. DOS
700 1 $aKAPRITCHKOFF, R. T. I.
700 1 $aCASTRO, K. N. de C.
700 1 $aCANUTO, K. M.
700 1 $aRODRIGUES, R. A. F.
700 1 $aCORREA, D. S.
700 1 $aCHAGAS, A. C. de S.
700 1 $aPASTRE, J. C.
773 $tVeterinary Parasitology$gv. 327, Apr. 2024, 110137.
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Registro original: |
Embrapa Agroindústria Tropical (CNPAT) |
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Biblioteca |
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| Registros recuperados : 63 | |
| 4. |  | ARF, O.; RODRIGUES, R. A. F.; NASCENTE, A. S.; LACERDA, M. C. Adubação antecipada de nitrogênio na cultura do arroz de terras altas sob plantio direto. Revista de Ciências Agrárias, Belém, PA, v. 58, n. 1, p. 6-13, jan./mar. 2015.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 2 |
| Biblioteca(s): Embrapa Arroz e Feijão. |
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| 9. | | ARF, O.; RODRIGUES, R. A. F.; SÁ, M. E. de; CRUSCIOL, C. A. C. Influência da época de semeadura no comportamento de cultivares de arroz irrigado por aspersão em Selviria, MS. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 35, n. 10, p. 1967-76, out. 2000. Título em inglês: Effects of sowing dates on performance of dryland rice cultivars under sprinkler irrigation, in Selvíria, MS, Brazil.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 11. | | JORCELINO, T. M.; RODRIGUES, R. A. F.; NORONHA, P. A.; OLIVEIRA, F. T. V. Empreendedorismo em biotecnologia: a importância dos patrimônios e recursos genéticos nos processos de Pesquisa, Desenvolvimento & Inovação (P,D&I). In: SIMPÓSIO MELHORAMENTO DE PLANTAS, 2., 2018. Brasília, DF. Equilíbrio entre o passado e o futuro: anais. Brasília, DF: Sociedade Brasileira de Melhoramento de Plantas, 2018.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 12. | | ARF, O.; RODRIGUES, R. A. F; NASCENTE, A. S.; LACERDA, M. C. Espaçamento e adubação nitrogenada afetando o desenvolvimento do arroz de terras altas sob plantio direto. Revista Ceres, Viçosa, MG, v. 62, n. 5, p. 475-482, set-out, 2015.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Arroz e Feijão. |
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| 14. | | RODRIGUES, R. A. L.; RIBEIRO, V. P.; THOMAZINI, A.; MARRIEL, I. E.; OLIVEIRA-PAIVA, C. A. Effect of phosphate solubilizing microorganisms on maize yield and yield attributes in the Sete Lagoas region. In: WORLD CONGRESS OF SOIL SCIENCE, 21., 2018, Rio de Janeiro. Soil science: beyond food and fuel: abstracts. Viçosa, MG: SBCS, 2018.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 15. | | ARF, O.; RODRIGUES, R. A. F.; SÁ, M. E. de; CRUSCIOL, C. A. C. Resposta de cultivares de arroz de sequeiro ao preparo do solo e a irrigação por aspersão. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 36, n. 6, p. 871-79, jun. 2001 Título em inglês: Performance of dryland rice cultivars in function of soil preparation systems and sprinkler irrigation.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 16. | | ARF, O.; RODRIGUES, R. A. F.; SÁ, M. E. de; BUZETTI, S.; NASCIMENTO, V. do. Manejo do solo, água e nitrogênio no cultivo de feijão. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 39, n. 2, p. 131-138, fev. 2004 Título em inglês: Soil, water and nitrogen management in common bean cultivation.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 17. | | OLIVEIRA, C. M.; NASCIMENTO, A. F.; PEDREIRA, B. C.; PEREIRA, D. H.; RODRIGUES, R. A. R. Nitrous oxide (N2O) emissions from soil cultivated with grass Marandu and subjected to rates and sources of N fertilizers in Amazon of Mato Grosso. In: INTERNATIONAL SYMPOSIUM ON GREENHOUSE GASES IN AGRICULTURE, 2., 2016, Campo Grande, MS. Proceedings... Brasília, DF: Embrapa, 2016. p. 27-31. (Embrapa Gado de Corte. Documentos, 216). Coordenador Roberto Giolo de Almeida. II SIGEE.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Solos. |
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| 18. | | CRUSCIOL, C. A. C.; MACHADO, J. R.; ARF, O.; RODRIGUES, R. A. F. Produtividade do arroz irrigado por aspersão em função do espaçamento e da densidade de semeadura. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 35, n. 6, p. 1093-1100, jun. 2000. Título em inglês: Yield of upland rice cultivated under sprinkler irrigation as a function of row spacing and seed density.| Biblioteca(s): Embrapa Unidades Centrais. |
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| Registros recuperados : 63 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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